Oversaturated Solutions of Drug in Hydroxypropylcyclodextrins: Parenteral Preparation of Pancratistatin

1991 ◽  
Vol 80 (4) ◽  
pp. 384-386 ◽  
Author(s):  
Juan J. Torres-Labandeira ◽  
Paul Davignon ◽  
Josef Pitha
Keyword(s):  
Parenteral Preparation

Parenteral 5-Fluorocytosine for Candidiasis

1979 ◽  
Vol 13 (2) ◽  
pp. 72-75 ◽  
Author(s):  
S. M. MacLeod ◽  
T. Y. Ti ◽  
R. B. Williams ◽  
E. M. Sellers
Keyword(s):  
North America ◽  
Adverse Effects ◽  
Fungal Infection ◽  
Amphotericin B ◽  
Invasive Fungal Infection ◽  
Invasive Candidiasis ◽  
Antifungal Drug ◽  
Investigational Drug ◽  
Clinically Significant ◽  
Parenteral Preparation

5-Fluorocytosine (5-FC), a systemic antifungal drug, has recently been approved for oral use in North America; however, the parenteral preparation remains an investigational drug. This report describes the use of parenteral 5-FC in nine patients with candidiasis. Six patients had invasive fungal infection and three patients had colonization. Eight patients received 5-FC intravenously and one received an intraperitoneal infusion. Of the six patients with invasive candidiasis, four received concurrent amphotericin B therapy. Candidiasis was cleared in eight of the nine patients. One patient died during therapy with combined 5-FC and amphotericin B. No clinically significant adverse effects of parenteral 5-FC were observed; however, two patients showed a transient increase in SGOT.

scholarly journals Infantile Iatrogenic Cushing Syndrome due to Topical Steroids

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Lulwah Alkhuder ◽  
Horia Mawlawi
Keyword(s):  
Pituitary Adenoma ◽  
Young Children ◽  
Cushing Syndrome ◽  
Topical Steroids ◽  
Age Group ◽  
Adrenal Hyperplasia ◽  
Inappropriate Use ◽  
Endogenous Release ◽  
Free Plasma ◽  
Parenteral Preparation

Cushing syndrome is an endocrinological disorder characterized by increased free plasma glucocorticoids level. It is either due to an excessive endogenous release of steroids (e.g., pituitary adenoma or adrenal hyperplasia) or exogenous administration of steroids. In children, iatrogenic Cushing syndrome is the most common form of Cushing syndrome occurring in this age group. The vast majority of cases are due to oral or parenteral preparation of steroids, which are commonly prescribed for pulmonary, hematological, renal, or autoimmune pathologies. Topical preparations can rarely cause Cushing syndrome in young children, and only a few cases were reported in the literature, where the patients were older than 5 months of age. In this report, we present a three-month-old girl who developed iatrogenic Cushing syndrome due to prolonged and inappropriate use of topical clobetasol cream for napkin dermatitis.

scholarly journals Incompatibility of Piperacillin Sodium in Parenteral Preparation

1981 ◽  
Vol 7 (2) ◽  
pp. 140-144
Author(s):  
KUNIICHI IKARASHI ◽  
KAZUHISA SASAHARA ◽  
YOSHIKAZU KOBAYASHI ◽  
YOSHIHISA SUGIURA ◽  
IWAMI TANEMURA ◽  
...  
Keyword(s):  
Parenteral Preparation
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