Racemization Kinetics of Enantiomeric Oxazepams and Stereoselective Hydrolysis of Enantiomeric Oxazepam 3-Acetates in Rat Liver Microsomes and Brain Homogenate

1989 ◽  
Vol 78 (10) ◽  
pp. 789-795 ◽  
Author(s):  
Shen K. Yang ◽  
Xiang-Lin Lu
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Brain Homogenate ◽  
Rat Liver Microsomes ◽  
Stereoselective Hydrolysis ◽  
Kinetics Of ◽  
Hydrolysis Of

Caffeine-derived N-nitroso compounds IV: kinetics of mononitrosocaffeidine demethylation by rat liver microsomes

1994 ◽  
Vol 79 (1) ◽  
pp. 117-122 ◽  
Author(s):  
Renu Razdan ◽  
Eva Frei ◽  
Bertold Spiegelhalder ◽  
Maqsood Siddiqi
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Nitroso Compounds ◽  
Rat Liver Microsomes ◽  
Kinetics Of

scholarly journals A STUDY OF THE NUCLEOSIDE TRI- AND DIPHOSPHATE ACTIVITIES OF RAT LIVER MICROSOMES

1962 ◽  
Vol 15 (3) ◽  
pp. 563-578 ◽  
Author(s):  
Lars Ernster ◽  
Lois C. Jones
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Physiological Role ◽  
Sodium Deoxycholate ◽  
Inorganic Pyrophosphatase ◽  
Rat Liver Microsomes ◽  
High Concentrations ◽  
Hydrolysis Of ◽  
No Activation

Rat liver microsomes catalyze the hydrolysis of the triphosphates of adenosine, guanosine, uridine, cytidine, and inosine into the corresponding diphosphates and inorganic orthophosphate. The activities are stimulated by Na2S2O4, and inhibited by atebrin, chlorpromazine, sodium azide, and deaminothyroxine. Sodium deoxycholate inhibits the ATPase activity in a progressive manner; the release of orthophosphate from GTP and UTP is stimulated by low, and inhibited by high, concentrations of deoxycholate, and that from CTP and ITP is unaffected by low, and inhibited by high, concentrations of deoxycholate. Subfractionation of microsomes with deoxycholate into ribosomal, membrane, and soluble fractions reveals a concentration of the triphosphatase activity in the membrane fraction. Rat liver microsomes also catalyze the hydrolysis of the diphosphates of the above nucleosides into the corresponding monophosphates and inorganic orthophosphate. Deoxycholate strongly enhances the GDPase, UDPase, and IDPase activities while causing no activation or even inhibition of the ADPase and CDPase activities. The diphosphatase is unaffected by Na2S2O4 and is inhibited by azide and deaminothyroxine but not by atebrin or chlorpromazine. Upon fractionation of the microsomes with deoxycholate, a large part of the GDPase, UDPase, and IDPase activities is recovered in the soluble fraction. Mechanical disruption of the microsomes with an Ultra Turrax Blender both activates and releases the GDPase, UDPase, and IDPase activities, and the former effect occurs more readily than the latter. The GDPase, UDPase, and IDPase activities of the rat liver cell reside almost exclusively in the microsomal fraction, as revealed by comparative assays of the mitochondrial, microsomal, and final supernatant fractions of the homogenate. The microsomes exhibit relatively low nucleoside monophosphatase and inorganic pyrophosphatase activities, and these are unaffected by deoxycholate or mechanical treatment. Different approaches toward the function of the liver microsomal nucleoside tri- and diphosphatases are reported, and the possible physiological role of the two enzymes is discussed.

scholarly journals KINETICS OF CYTOCHROME b5 IN RAT LIVER MICROSOMES

1954 ◽  
Vol 209 (2) ◽  
pp. 945-951 ◽  
Author(s):  
Britton Chance ◽  
G.R. Williams
Keyword(s):  
Rat Liver ◽  
Cytochrome B5 ◽  
Liver Microsomes ◽  
Rat Liver Microsomes ◽  
Kinetics Of

KINETICS OF BENZOPYRENE AND 3-HYDROXYBENZOPYRENE METABOLISM IN RAT LIVER MICROSOMES

Abstracts ◽  
1977 ◽  
pp. 382
Author(s):  
J.B. Schenkman ◽  
K.M. Robie ◽  
R.E. Talcott ◽  
Y.N. Cha
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Rat Liver Microsomes ◽  
Kinetics Of

Diastereospecific kinetics of nicotineN-oxidation in rat liver microsomes

Xenobiotica ◽  
1998 ◽  
Vol 28 (2) ◽  
pp. 127-134 ◽  
Author(s):  
M. NAKAJIMA ◽  
K. IWATA ◽  
T. YOSHIDA ◽  
T. YAMAMOTO ◽  
Y. KUROIWA
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Rat Liver Microsomes ◽  
Kinetics Of
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