Moment analysis of drug disposition in kidney: Transcellular transport kinetics of p-Aminohippurate in the Isolated Perfused Rat Kidney

1988 ◽  
Vol 77 (6) ◽  
pp. 471-476 ◽  
Author(s):  
Ryohei Hori ◽  
Yusuke Tanigawara ◽  
Yoshihiro Saito ◽  
Yoshie Hayashi ◽  
Tetsuya Aiba ◽  
...  
Keyword(s):  
Drug Disposition ◽  
Rat Kidney ◽  
Transport Kinetics ◽  
Moment Analysis ◽  
Transcellular Transport ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney ◽  
Kinetics Of

Tubular reabsorption rates for myoglobin in the isolated perfused rat kidney

1986 ◽  
Vol 70 (6) ◽  
pp. 595-599 ◽  
Author(s):  
P. J. Ratcliffe ◽  
M. P. Esnouf ◽  
J. G. G. Ledingham
Keyword(s):  
Rat Kidney ◽  
Tubular Reabsorption ◽  
Renal Tubules ◽  
Immunoglobulin Light Chain ◽  
Renal Handling ◽  
Water Excretion ◽  
Isolated Perfused Rat Kidney ◽  
Saturation Kinetics ◽  
Perfused Rat Kidney ◽  
Kinetics Of

1. The renal handling of myoglobin has been studied in the isolated perfused rat kidney. 2. Myoglobin was freely filtered. Reabsorption by the renal tubules showed saturation kinetics with a relatively low maximum rate of reabsorption (Tmax) of 27-30 μg min−1 g−1 wet wt. at a perfusate concentration of 70-80 μg/ml. Myoglobin reabsorption is therefore much less than that reported for immunoglobulin light chain or lysozyme in this model. 3. Large increases in sodium and water excretion produced by omission of oncotic agent from the perfusate did not alter the kinetics of myoglobin reabsorption. 4. The use of bovine serum albumin as oncotic agent in the perfusate prevented the tubular reabsorption of myoglobin. Small amounts of albumin are filtered by the isolated perfused kidney and it is postulated that this albumin interferes with tubular reabsorption of myoglobin.

Validation of a toxicity testing model by evaluating oxygen supply and energy state in the isolated perfused rat kidney

1991 ◽  
Vol 25 (3) ◽  
pp. 195-204 ◽  
Author(s):  
Takano Takehito ◽  
Nakata Kazuyo ◽  
Kawakami Tsuyoshi ◽  
Miyazaki Yoshifumi ◽  
Murakami Masataka ◽  
...  
Keyword(s):  
Oxygen Supply ◽  
Energy State ◽  
Rat Kidney ◽  
Toxicity Testing ◽  
Testing Model ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney

Aldosterone Effects on Renal Function in the Isolated Perfused Rat Kidney

1979 ◽  
Vol 2 (1) ◽  
pp. 1-11
Author(s):  
Richard Solomon ◽  
Patricio Silva ◽  
Franklin H. Epstein
Keyword(s):  
Renal Function ◽  
Rat Kidney ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney

EFFECTS OF CYCLOSPORINE ON THE ISOLATED PERFUSED RAT KIDNEY

1987 ◽  
Vol 43 (6) ◽  
pp. 795-799 ◽  
Author(s):  
David R. Luke ◽  
Bertram L. Kasiske ◽  
Gary R. Matzke ◽  
Walid M. Awni ◽  
William F. Keane
Keyword(s):  
Rat Kidney ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney
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