Liquid Chromatographic Procedure for the Quantitative Analysis of Carboplatin in Beagle Dog Plasma Ultrafiltrate

1988 ◽  
Vol 77 (3) ◽  
pp. 273-276 ◽  
Author(s):  
Glenn F. Duncan ◽  
Harold C. Faulkner ◽  
Raymond H. Farmen ◽  
Kenneth A. Pittman
Keyword(s):  
Quantitative Analysis ◽  
Beagle Dog ◽  
Dog Plasma ◽  
Chromatographic Procedure ◽  
Liquid Chromatographic ◽  
Plasma Ultrafiltrate

Liquid Chromatographic Procedure for the Quantitative Analysis of Megestrol Acetate in Human Plasma

1985 ◽  
Vol 74 (6) ◽  
pp. 664-667 ◽  
Author(s):  
Robert C. Gaver ◽  
Hassan S. Movahhed ◽  
Raymond H. Farmen ◽  
Kenneth A. Pittman
Keyword(s):  
Quantitative Analysis ◽  
Human Plasma ◽  
Megestrol Acetate ◽  
Chromatographic Procedure ◽  
Liquid Chromatographic

scholarly journals Development of an UPLC-MS/MS Method for the Quantitative Analysis of Upadacitinib in Beagle Dog Plasma and Pharmacokinetics Study

2021 ◽  
Vol Volume 15 ◽  
pp. 4167-4175
Author(s):  
Meng-Jie Wang ◽  
Yu-Hang Zhao ◽  
Chen Fan ◽  
Ying-Jie Wang ◽  
Xin-Qi Wang ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Beagle Dog ◽  
Pharmacokinetics Study ◽  
Dog Plasma

Simultaneous liquid-chromatographic determination of vitamin K1 and vitamin E in serum.

1989 ◽  
Vol 35 (12) ◽  
pp. 2285-2289 ◽  
Author(s):  
B E Cham ◽  
H P Roeser ◽  
T W Kamst
Keyword(s):  
Vitamin E ◽  
Human Serum ◽  
High Performance ◽  
Chromatographic Determination ◽  
High Performance Liquid Chromatographic ◽  
Tocopheryl Acetate ◽  
Vitamin K1 ◽  
Chromatographic Procedure ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Abstract We describe a high-performance liquid chromatographic procedure for the simultaneous measurement of vitamins K1 and E in human serum. Delipidated human serum (free of vitamins K1 and E) was used to make standard solutions of these vitamins, and cetyl naphthoate and alpha-tocopheryl acetate were the internal standards for vitamin K1 and vitamin E, respectively. A simple, novel separation method utilizing liquid-liquid partition chromatography was used as a preparative "clean-up" procedure. Cetyl naphthoate and vitamin K1 (after post-column reduction) were detected by fluorescence, alpha-tocopheryl acetate and vitamin E by ultraviolet absorption. Sensitivity (detection limit) of the assay was 30 pg for vitamin K1 and 5 ng for vitamin E per injection. The method is specific, precise, and more rapid than previously described procedures. Within- and between-assay CVs were 8.1% and 12.9%, respectively, for vitamin K1; 3.5% and 6.0%, respectively, for vitamin E. Analytical recoveries of vitamins K1 and E were 80% and 93%, respectively, from serum and from delipidated serum (standards). The average neonatal serum concentration of vitamin K1 was 83 ng/L, 2.5 mg/L for vitamin E; for normolipidemic adults, the values were 343 ng/L and 7.9 mg/L, respectively, and for hyperlipidemic adults, 541 ng/L and 11.1 mg/L, respectively.

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