A New Approach for Dealing with the Stability of Drugs in Biological Fluids

1985 ◽  
Vol 74 (9) ◽  
pp. 972-977 ◽  
Author(s):  
U. Timm ◽  
M. Wall ◽  
D. Dell
Keyword(s):  
Biological Fluids ◽  
New Approach ◽  
The Stability ◽  
Drugs In Biological Fluids

Host-Guest Interactions on Electrode Surfaces for Immobilization of Molecular Catalysts

2020 ◽  
Author(s):  
Laurent Sévery ◽  
Jacek Szczerbiński ◽  
Mert Taskin ◽  
Isik Tuncay ◽  
Fernanda Brandalise Nunes ◽  
...  
Keyword(s):  
Aqueous Media ◽  
Heterogeneous Systems ◽  
Catalytic Systems ◽  
New Approach ◽  
Molecular Systems ◽  
Electrode Surfaces ◽  
Catalytic Surfaces ◽  
Oxide Electrodes ◽  
The Stability ◽  
Molecular Catalysts

The strategy of anchoring molecular catalysts on electrode surfaces combines the high selectivity and activity of molecular systems with the practicality of heterogeneous systems. The stability of molecular catalysts is, however, far less than that of traditional heterogeneous electrocatalysts, and therefore a method to easily replace anchored molecular catalysts that have degraded could make such electrosynthetic systems more attractive. Here, we apply a non-covalent “click” chemistry approach to reversibly bind molecular electrocatalysts to electrode surfaces via host-guest complexation with surface-anchored cyclodextrins. The host-guest interaction is remarkably strong and allows the flow of electrons between the electrode and the guest catalyst. Electrosynthesis in both organic and aqueous media was demonstrated on metal oxide electrodes, with stability on the order of hours. The catalytic surfaces can be recycled by controlled release of the guest from the host cavities and readsorption of fresh guest. This strategy represents a new approach to practical molecular-based catalytic systems.

scholarly journals Methodology and Models for Individuals’ Creditworthiness Management Using Digital Footprint Data and Machine Learning Methods

Mathematics ◽  
2021 ◽  
Vol 9 (15) ◽  
pp. 1820
Author(s):  
Ekaterina V. Orlova
Keyword(s):  
Interest Rates ◽  
Additional Data ◽  
Risk Level ◽  
Gradient Boosting ◽  
Cluster Number ◽  
New Approach ◽  
Credit Risks ◽  
Stochastic Gradient Boosting ◽  
The Stability ◽  
Digital Footprints

This research deals with the challenge of reducing banks’ credit risks associated with the insolvency of borrowing individuals. To solve this challenge, we propose a new approach, methodology and models for assessing individual creditworthiness, with additional data about borrowers’ digital footprints to implement comprehensive analysis and prediction of a borrower’s credit profile. We suggest a model for borrowers’ clustering based on the method of hierarchical clustering and the k-means method, which groups actual borrowers having similar creditworthiness and similar credit risks into homogeneous clusters. We also design the model for borrowers’ classification based on the stochastic gradient boosting (SGB) method, which reliably determines the cluster number and therefore the risk level for a new borrower. The developed models are the basis for decision making regarding the decision about lending value, interest rates and lending terms for each risk-homogeneous borrower’s group. The modified version of the methodology for assessing individual creditworthiness is presented, which is to reduce the credit risks and to increase the stability and profitability of financial organizations.

A new approach to the stability analysis of thawing slopes

1980 ◽  
Vol 17 (4) ◽  
pp. 607-612 ◽  
Author(s):  
Luis E. Vallejo
Keyword(s):  
Stability Analysis ◽  
Water Content ◽  
Pore Water ◽  
Active Layer ◽  
Necessary Conditions ◽  
Mass Movements ◽  
New Approach ◽  
Pore Water Pressures ◽  
The Stability ◽  
Excess Pore

A new approach to the stability analysis of thawing slopes at shallow depths, taking into consideration their structure (this being a mixture of hard crumbs of soil and a fluid matrix), is presented. The new approach explains shallow mass movements such as skin flows and tongues of bimodal flows, which usually take place on very low slope inclinations independently of excess pore water pressures or increased water content in the active layer, which are necessary conditions in the methods available to date to explain these movements.

THE DEVELOPMENT OF A METHOD FOR DIRECT MASS SPECTROMETRIC ANALYSIS OF BIOLOGICAL SAMPLES USING POROUS SAMPLERS

2021 ◽  
Vol 55 (1) ◽  
pp. 99-103
Author(s):  
R.E. Levin ◽  
◽  
M.A. Shamraeva ◽  
I.M. Larina ◽  
D.S. Bormotov ◽  
...  
Keyword(s):  
Biological Samples ◽  
Biological Fluids ◽  
Storage Conditions ◽  
Spectrometric Analysis ◽  
Sample Collection ◽  
Mucous Membranes ◽  
The Status ◽  
Direct Mass Spectrometry ◽  
The Stability ◽  
Blood Spot

The paper presents a method for rapid multi-omics investigation of biological samples using polypropylene bulk porous samplers. The use of porous samplers makes it easy to collect samples from the surface of the skin, mucous membranes, and biological fluids even in a field, and the surfaces of wounds and injuries. Collected samples do not require special storage conditions, and the samplers are lightweight and very compact. They can be used to monitor the condition of cosmonauts before, during, and after the spaceflight with the same sample collection method. The analysis of biomaterial applied to the sampler is performed using direct mass spectrometry methods, similar to the dried blood spot technique that is already used in clinical practice. However, bulk porous samplers allow expanding the range of analytes ionization conditions, which increases the stability and reliability of the ionization process, which expands the variety of analyzed molecules. The proposed method can be used to study compounds of various classes, including proteins, lipids, and metabolites, to systematically monitor the status of people in extreme conditions (athletes, astronauts), or to study the condition of patients in the clinic.

scholarly journals INTEGRAL TRANSFORM TECHNIQUE FOR MESON WAVE FUNCTIONS

1996 ◽  
Vol 11 (20) ◽  
pp. 1611-1626 ◽  
Author(s):  
A.P. BAKULEV ◽  
S.V. MIKHAILOV
Keyword(s):  
Wave Function ◽  
Sum Rules ◽  
Integral Transform ◽  
Wave Functions ◽  
Sum Rule ◽  
New Approach ◽  
Exactly Solvable ◽  
The Stability ◽  
The Masses ◽  
Integral Transform Technique

In a recent paper1 we have proposed a new approach for extracting the wave function of the π-meson φπ(x) and the masses and wave functions of its first resonances from the new QCD sum rules for nondiagonal correlators obtained in Ref. 2. Here, we test our approach using an exactly solvable toy model as illustration. We demonstrate the validity of the method and suggest a pure algebraic procedure for extracting the masses and wave functions relating to the case under investigation. We also explore the stability of the procedure under perturbations of the theoretical part of the sum rule. In application to the pion case, this results not only in the mass and wave function of the first resonance (π′), but also in the estimation of π″-mass.

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