Pharmacokinetics of Mitomycin C in Dogs: Application of a High-Performance Liquid Chroma tograp h ic Assay

1984 ◽  
Vol 73 (9) ◽  
pp. 1220-1223 ◽  
Author(s):  
R.H. Barbhaiya ◽  
E.A. Papp ◽  
D.R. Van Harken ◽  
R.D. Smyth
Keyword(s):  
Mitomycin C ◽  
High Performance ◽  
High Performance Liquid Chroma

scholarly journals Research of Polyocarboxy Acid Water-Reducer with Modified Ployether and its Effect on Concrete’s Workability

2011 ◽  
Vol 250-253 ◽  
pp. 2032-2035 ◽  
Author(s):  
Lu Feng Pang ◽  
Xin Xin Zhou
Keyword(s):  
High Performance ◽  
High Performance Liquid Chroma ◽  
Reducing Agents ◽  
Acid Water ◽  
Concrete Mixture ◽  
Synthetic Temperature ◽  
Naphthalene Series ◽  
High Range

In this paper, polycarboxylic type high performance water reducers have been synthesized through using TPEG modified monomer. If synthetic temperature and addition time of copolymer monomers can be controlled, the performance of polycarboxylic superplasticizer will be improved. Testing results indicates that when temperature is at 60~65°C, addition time of copolymer monomers is three hours, the performance of superplasticizer is best. Through High Performance Liquid Chroma- tography (HPLC) testing, we can find it is almost the same with the famous brand abroad of the same type. The ues of polycarboxylic type high performance water reducers cooperated with naphthalene series high range water reducing agents thereby markedly improv the workability of concrete mixture.

Mitomycin C pharmacokinetics in patients with recurrent or metastatic colorectal carcinoma

1987 ◽  
Vol 65 (3) ◽  
pp. 407-411 ◽  
Author(s):  
Charles Erlichman ◽  
A. Michael Rauth ◽  
Rena Battistella ◽  
Sheldon Fine
Keyword(s):  
Colorectal Carcinoma ◽  
Mitomycin C ◽  
High Performance ◽  
Single Agent ◽  
Area Under The Curve ◽  
Metastatic Colorectal Carcinoma ◽  
Active Metabolites ◽  
Small Component ◽  
Drug Concentrations ◽  
Hplc Technique

The pharmacokinetics of mitomycin C as a single agent have been determined in 25 treatment courses given to 18 patients with recurrent or metastatic colorectal carcinoma using a high performance liquid chromatography (HPLC) assay to analyze plasma and urine samples. The plasma pharmacokinetics conformed to a two-compartment linear model in 21 of 25 courses monitored with a mean t½λ1 of 9.8 ± 1.2 (SEM) min and mean t½λz of 64.1 ± 8.9 (SEM) min. The large variation observed in t½λz was not related to dose or treatment, but an interaction of these two factors approached significance (p = 0.057). Renal excretion in the 12 courses in which it was determined averaged only 2.3% of the total administered dose during the first 4 h monitored and no mitomycin C metabolites were detected in plasma or urine by the HPLC technique used. The most common toxicity, thrombocytopenia, did not correlate with t½λz or the area under the curve. This may be due to (i) a failure to monitor active metabolites of mitomycin C; (ii) other factors besides plasma drug concentrations that mediate toxicity towards marrow elements; or (iii) the small number of courses associated with thrombocytopenia (<100 000/mm3). Our study indicates that (i) an interaction of drug dose and treatment course may be associated with increasing t½λz; (ii) the renal clearance contributes a small component of mitomycin C elimination; (iii) metabolites of mitomycin C cannot be detected by the present HPLC technique; and (iv) routine monitoring of mitomycin C using present methods cannot be recommended for clinical use to predict toxicity.

High Performance Liquid Chroma Tography of Cytokinins

1985 ◽  
Vol 8 (2) ◽  
pp. 369-379 ◽  
Author(s):  
Arild Ernstsen ◽  
Einar Jensen
Keyword(s):  
High Performance ◽  
High Performance Liquid Chroma
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