Liquid Chromatographic Chiral Stationary Phases in Pharmaceutical Analysis: Determination of Trace Amounts of the (-)-Enantiomer in (+)-Amphetamine

1984 ◽  
Vol 73 (8) ◽  
pp. 1162-1164 ◽  
Author(s):  
Irving W. Wainerx ◽  
Thomas D. Doyle ◽  
William M. Adams
Keyword(s):  
Pharmaceutical Analysis ◽  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
Liquid Chromatographic ◽  
Analysis Determination

Application of high-performance liquid chromatographic chiral stationary phases to pharmaceutical analysis

1985 ◽  
Vol 324 ◽  
pp. 444-449 ◽  
Author(s):  
Zhong-Yuan Yang ◽  
Susan Barkan ◽  
Charlote Brunner ◽  
John D. Weber ◽  
Thomas D. Doyle ◽  
...  
Keyword(s):  
Pharmaceutical Analysis ◽  
High Performance ◽  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
High Performance Liquid Chromatographic ◽  
Liquid Chromatographic

Gas-Liquid Chromatographic Determination of Technical Chlordane Residues in Food Crops: Interpretation of Analytical Data

1975 ◽  
Vol 58 (5) ◽  
pp. 1051-1061
Author(s):  
William P Cochrane ◽  
James F Lawrence ◽  
Young W Lee ◽  
Ronald B Maybury ◽  
Brian P Wilson
Keyword(s):  
Field Experiments ◽  
Stationary Phases ◽  
Analytical Data ◽  
Chromatographic Determination ◽  
Electron Capture Detection ◽  
Food Crops ◽  
Liquid Chromatographic Determination ◽  
Consistent Method ◽  
Liquid Chromatographic

Abstract An interlaboratory investigation of technical chlordane residues in food crops was carried out to determine the most practical and consistent method of reporting results. Using a technical chlordane reference standard, 8 gas chromatographic stationary phases were studied for their resolution capabilities. The best separations were obtained with SE-30 and its OV-1 equivalent. Using these columns and electron capture detection, potatoes and carrots from supervised field experiments were analyzed in duplicate and quantitated by using 4 methods of calculation. The data were statistically treated to determine the precision and bias for each method. Also, 1 sample was analyzed in duplicate on 2 different occasions by 6 laboratories to substantiate the initial conclusions. Based on the criterion of high precision it is suggested that a comparison of total area under the chromatogram of the sample with total area of a standard technical chlordane be the method of quantitation. Only peaks which are common to both standard and sample have any significance in this type of calculation.

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