Quantitative Investigation of Renal Handling of Drugs in Dogs with Renal Insufficiency

1984 ◽  
Vol 73 (7) ◽  
pp. 892-896 ◽  
Author(s):  
Akira Kamiya ◽  
Katsuhiko Okumura ◽  
Ryohei Hori
Keyword(s):  
Renal Insufficiency ◽  
Quantitative Investigation ◽  
Renal Handling

Quantitative Investigation on Renal Handling of Drugs in Rabbits, Dogs, and Humans

1983 ◽  
Vol 72 (4) ◽  
pp. 440-443 ◽  
Author(s):  
Akira Kamiya ◽  
Katsuhiko Okumura ◽  
Ryohei Hori
Keyword(s):  
Quantitative Investigation ◽  
Renal Handling

scholarly journals Renal handling of potassium in dogs with chronic renal insufficiency

1981 ◽  
Vol 20 (4) ◽  
pp. 482-490 ◽  
Author(s):  
Jacques J. Bourgoignie ◽  
Michael Kaplan ◽  
Jillian Pincus ◽  
George Gavellas ◽  
Alexander Rabinovitch
Keyword(s):  
Renal Insufficiency ◽  
Chronic Renal Insufficiency ◽  
Renal Handling

Renal Handling of Citrate in Chronic Renal Insufficiency

Nephron ◽  
1991 ◽  
Vol 57 (4) ◽  
pp. 439-443 ◽  
Author(s):  
Martino Marangella ◽  
Corrado Vitale ◽  
Marco Manganaro ◽  
Domenico Cosseddu ◽  
Caterina Martini ◽  
...  
Keyword(s):  
Renal Insufficiency ◽  
Chronic Renal Insufficiency ◽  
Renal Handling

scholarly journals RENAL HANDLING OF PHOSPHATE IN CHILDREN WITH VARIOUS STAGES OF RENAL INSUFFICIENCY

1980 ◽  
Vol 14 (8) ◽  
pp. 988-988 ◽  
Author(s):  
J Brodehl ◽  
G Offner ◽  
G Weqener
Keyword(s):  
Renal Insufficiency ◽  
Renal Handling

scholarly journals Renal handling of silicon in normals and patients with renal insufficiency

1992 ◽  
Vol 42 (4) ◽  
pp. 957-959 ◽  
Author(s):  
Hillel J. Gitelman ◽  
Frances Alderman ◽  
Samuel J. Perry
Keyword(s):  
Renal Insufficiency ◽  
Renal Handling

Renal extraction of glucagon in rats with normal and reduced renal function

1977 ◽  
Vol 233 (1) ◽  
pp. F67-F71 ◽  
Author(s):  
C. Bastl ◽  
F. O. Finkelstein ◽  
R. Sherwin ◽  
R. Hendler ◽  
P. Felig ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Insufficiency ◽  
Normal Renal Function ◽  
Filtration Rate ◽  
Metabolic Clearance ◽  
Elevated Plasma ◽  
Kidney Weight ◽  
Surgical Ablation ◽  
Renal Handling

To examine the role of the kidney in the mechanism of impaired metabolic clearance of glucagon in renal failure, the renal handling of endogenous pancreatic glucagon was studied in rats with normal renal function and rats with renal insufficiency produced by 70% surgical ablation. Mean +/- SE renal extraction of glucagon in animals with normal renal function was 39 +/- 5%. Urinary losses of glucagon accounted for less than 2% of renal extraction. In contrast, in the animals with renal insufficiency (glomerular filtration rate reduced to one-third of normal), arterial glucagon increased 40% and renal extraction and extraction rate per gram kidney weight of glucagon were negligible, despite filtered loads of 204 +/- 42 pg/min per g kidney wt. These findings indicate a major role of the kidney in the metabolic clearance of glucagon under normal conditions and suggest that during renal insufficiency elevated plasma levels of glucagon occur, at least in part, as a result of a decreased renal turnover of the hormone.

Divalent Ion Excretion in Chronic Kidney Disease: Relation to Degree of Renal Insufficiency

1970 ◽  
Vol 38 (3) ◽  
pp. 297-307 ◽  
Author(s):  
M. M. Popovtzer ◽  
L. I. Schainuck ◽  
S. G. Massry ◽  
C. R. Kleeman
Keyword(s):  
Renal Failure ◽  
Renal Insufficiency ◽  
Renal Disease ◽  
Close Association ◽  
Fractional Excretion ◽  
Normal Subjects ◽  
Common Mechanism ◽  
Severe Renal Failure ◽  
Renal Handling ◽  
Sodium Magnesium

1. The excretory patterns of sodium, calcium, magnesium and phosphorus were evaluated in seventy-eight patients with varying degrees of renal insufficiency, and in twelve normal subjects. 2. In mild renal failure the fractional excretion of filtered sodium, magnesium and phosphorus are significantly higher while that of calcium is significantly lower than values seen in normals. In advanced renal failure the fractional excretions of the filtered loads of all these ions increase steeply. These patterns are not influenced by the type of renal disease. 3. The fractional excretions of filtered sodium and calcium, calcium and magnesium, and sodium and magnesium were plotted against each other. The analysis of the plots showed that the fractional excretions of their filtered loads correlate poorly in patients with mild and moderate renal insufficiency, but closely in patients with severe renal failure. 4. These results indicate that the relation between the renal handling of divalent ions is not uniform at all levels of renal insufficiency. The dissociation between the excretory patterns observed in patients with early renal failure is consistent with the concept that different mechanisms may influence each individual ion separately. This is in contrast to the close association which exists between the excretory patterns of these ions in patients with advanced renal disease, and in which a single common mechanism may underlie the renal handling of these ions.

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