Improved Delivery Through Biological Membranes XIV: Brain-Specific, Sustained Delivery of Testosterone Using a Redox Chemical Delivery System

1984 ◽  
Vol 73 (3) ◽  
pp. 385-389 ◽  
Author(s):  
Nicholas Bodor ◽  
Hassan H. Farag
Keyword(s):  
Delivery System ◽  
Biological Membranes ◽  
Sustained Delivery ◽  
Chemical Delivery System

Improved Delivery through Biological Membranes XXXI: Solubilization and Stabilization of an Estradiol Chemical Delivery System by Modified β‐Cyclodextrins

1988 ◽  
Vol 77 (11) ◽  
pp. 981-985 ◽  
Author(s):  
Marcus E. Brewster ◽  
Kerry S. Estes ◽  
Thorsteinn Loftsson ◽  
Robert Perchalski ◽  
Hartmut Derendorf ◽  
...  
Keyword(s):  
Delivery System ◽  
Biological Membranes ◽  
Chemical Delivery System

Injectable in situ gelling delivery system for the treatment of jawbone infections

2021 ◽  
Author(s):  
Shreshtha Dash ◽  
Somnath Singh ◽  
Alekha K Dash
Keyword(s):  
Lactic Acid ◽  
Sustained Release ◽  
Cell Viability ◽  
Yield Stress ◽  
Delivery System ◽  
Pluronic F127 ◽  
Sustained Delivery ◽  
In Situ Gelling ◽  
Sustained Rate

Aim: A polymeric in situ gelling delivery system for localized and sustained delivery to jawbone infections was developed. Materials & methods: In situ gelling delivery systems were prepared using either poly-dl-lactic acid or chitosan and Pluronic F127/Pluronic F68. Metronidazole nanoparticles were prepared using poly (dl-lactide-co-glycolide) or chitosan. Poly (dl-lactide-co-glycolide) was used for microparticles. Particles were characterized for size, charge and morphology. Results: Viscosity and yield stress of the gels were 0.4 Pa.s and 2 Pa, respectively, with 70% cell viability over 72 h. Around 90% of loaded metronidazole was released at a sustained rate over 1 week. Conclusion: Use of appropriate amount of nano/microparticles in the gel resulted in a sustained release over a period of 1 week – needed for jawbone infection.

Development of an Insulin Nano-Delivery System through Buccal Administration

2022 ◽  
Vol 19 ◽  
Author(s):  
Diaa Al-Domi ◽  
Ayat Bozeya ◽  
Mohamed Al-Fandi
Keyword(s):  
Insulin Release ◽  
Delivery System ◽  
Polymeric Nanoparticles ◽  
Sustained Delivery ◽  
Atomic Force ◽  
Oil In Water ◽  
In Vitro Investigation ◽  
Coating Method ◽  
Evaporation Technique

Aim: To develop a new nano-delivery system for insulin buccal administration. Background: Biodegradable polymeric nanoparticles (PNPs) had viewed countless breakthroughs in drug delivery systems. The main objective of PNPs application in delivering and carrying different promising drugs is to make sure that the drugs being delivered to their action sites. As a result maximizing the desired effect and overcoming their limitations and drawbacks. Objectives: The main goals of this study were to produce an insulin consumable nano-delivery system for buccal administration and enhance the mucoadhesive effect in sustaining insulin release. Methods: Water in oil in water (W-O-W) microemulsion solvent evaporation technique was used for the preparation of nanoparticles consisting from positively charged poly (D, L-lactide-co-glycolide) coated with chitosan and loaded with insulin. Later, a consumable buccal film was prepared by the spin coating method and loaded with the previously prepared nanoparticles. Results: The newly prepared nanoparticle was assessed in terms of size, charge and surface morphology using a Scanning Electron Microscope (SEM), zeta potential, Atomic Force Microscope (AFM), and Fourier Transform Infra-red (FTIR) spectroscopy. An in-vitro investigation of the insulin release, from nanoparticles and buccal film, demonstrated controlled as well as sustained delivery over 6 hrs. The cumulative insulin release decreased to about (28.9%) with buccal film in comparing with the nanoparticle (50 %). Conclusion: The buccal film added another barrier for insulin release. Therefore, the release was sustained.

scholarly journals Chemical Delivery System of MIBG to the Central Nervous System: Synthesis, 11C-Radiosynthesis, and in Vivo Evaluation

2019 ◽  
Vol 10 (3) ◽  
pp. 352-357 ◽  
Author(s):  
Fabienne Gourand ◽  
Delphine Patin ◽  
Axelle Henry ◽  
Méziane Ibazizène ◽  
Martine Dhilly ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Delivery System ◽  
In Vivo Evaluation ◽  
System Synthesis ◽  
Chemical Delivery System ◽  
The Central Nervous System

Development of pellets of nifedipine using HPMC K15 M and κ-carrageenan as mucoadhesive sustained delivery system and in vitro evaluation

2013 ◽  
Vol 22 (12) ◽  
pp. 911-921 ◽  
Author(s):  
Pradum Pundlikrao Ige ◽  
Pravin Rajput ◽  
Chandrakantsingh Pardeshi ◽  
Rajendra Kawade ◽  
Bramhanand Swami ◽  
...  
Keyword(s):  
Delivery System ◽  
Sustained Delivery ◽  
In Vitro Evaluation
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