Molecular Connectivity Analysis of Hallucinogenic Mescaline Analogs

1979 ◽  
Vol 68 (7) ◽  
pp. 906-907 ◽  
Author(s):  
R.A. Glennon ◽  
L.B. Kier ◽  
A.T. Shulgin
Keyword(s):  
Connectivity Analysis ◽  
Molecular Connectivity

Identifying Breast Cancer-induced gene perturbations and its application in guiding drug repurposing

2020 ◽  
Vol 15 ◽  
Author(s):  
Jujuan Zhuang ◽  
Shuang Dai ◽  
Lijun Zhang ◽  
Pan Gao ◽  
Yingmin Han ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Enrichment Analysis ◽  
Cancer Tissue ◽  
Connectivity Analysis ◽  
Cancer Drugs ◽  
Normal Tissues ◽  
Differential Gene ◽  
Differential Modules ◽  
Differential Connectivity

Background: Breast cancer is a complex disease with high prevalence in women, the molecular mechanisms of which are still unclear at present. Most transcriptomic studies on breast cancer focus on differential expression of each gene between tumor and the adjacent normal tissues, while the other perturbations induced by breast cancer including the gene regulation variations, the changes of gene modules and the pathways, which might be critical to the diagnosis, treatment and prognosis of breast cancer are more or less ignored. Objective: We presented a complete process to study breast cancer from multiple perspectives, including differential expression analysis, constructing gene co-expression networks, modular differential connectivity analysis, differential gene connectivity analysis, gene function enrichment analysis key driver analysis. In addition, we prioritized the related anti-cancer drugs based on enrichment analysis between differential expression genes and drug perturbation signatures. Methods: The RNA expression profiles of 1109 breast cancer tissue and 113 non-tumor tissues were downloaded from The Cancer Genome Atlas (TCGA) database. Differential expression of RNAs was identified using the “DESeq2” bioconductor package in R, and gene co-expression networks was constructed using the weighted gene co-expression network analysis (WGCNA). To compare the module changes and gene co-expression variations between tumor and the adjacent normal tissues, modular differential connectivity (MDC) analysis and differential gene connectivity analysis (DGCA) were performed. Results: Top differential genes like MMP11 and COL10A1 were known to be associated with breast cancer. And we found 23 modules in the tumor network had significantly different co-expression patterns. The top differential modules were enriched in Goterms related to breast cancer like MHC protein complex, leukocyte activation, regulation of defense response and so on. In addition, key genes like UBE2T driving the top differential modules were significantly correlated with the patients’ survival. Finally, we predicted some potential breast cancer drugs, such as Eribulin, Taxane, Cisplatin and Oxaliplatin. Conclusion: As an indication, this framework might be useful in understanding the molecular pathogenesis of diseases like breast cancer and inferring useful drugs for personalized medication

scholarly journals Deep-sea amphipods around cobalt-rich ferromanganese crusts: Taxonomic diversity and selection of candidate species for connectivity analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (2) ◽  
pp. e0228483
Author(s):  
Akira Iguchi ◽  
Miyuki Nishijima ◽  
Yuki Yoshioka ◽  
Aika Miyagi ◽  
Ryuichi Miwa ◽  
...  
Keyword(s):  
Deep Sea ◽  
Taxonomic Diversity ◽  
Connectivity Analysis ◽  
Ferromanganese Crusts ◽  
Candidate Species ◽  
Selection Of

Application of geostatistical seismic inversion in reservoir characterization of Sapphire gas field, offshore Nile Delta, Egypt

2019 ◽  
Vol 38 (6) ◽  
pp. 474-479
Author(s):  
Mohamed G. El-Behiry ◽  
Said M. Dahroug ◽  
Mohamed Elattar
Keyword(s):  
Reservoir Characterization ◽  
Nile Delta ◽  
Seismic Inversion ◽  
Reservoir Modeling ◽  
Connectivity Analysis ◽  
Gas Field ◽  
Geostatistical Inversion ◽  
Well Data ◽  
Reservoir Connectivity ◽  
Inversion Techniques

Seismic reservoir characterization becomes challenging when reservoir thickness goes beyond the limits of seismic resolution. Geostatistical inversion techniques are being considered to overcome the resolution limitations of conventional inversion methods and to provide an intuitive understanding of subsurface uncertainty. Geostatistical inversion was applied on a highly compartmentalized area of Sapphire gas field, offshore Nile Delta, Egypt, with the aim of understanding the distribution of thin sands and their impact on reservoir connectivity. The integration of high-resolution well data with seismic partial-angle-stack volumes into geostatistical inversion has resulted in multiple elastic property realizations at the desired resolution. The multitude of inverted elastic properties are analyzed to improve reservoir characterization and reflect the inversion nonuniqueness. These property realizations are then classified into facies probability cubes and ranked based on pay sand volumes to quantify the volumetric uncertainty in static reservoir modeling. Stochastic connectivity analysis was also applied on facies models to assess the possible connected volumes. Sand connectivity analysis showed that the connected pay sand volume derived from the posterior mean of property realizations, which is analogous to deterministic inversion, is much smaller than the volumes generated by any high-frequency realization. This observation supports the role of thin interbed reservoirs in facilitating connectivity between the main sand units.

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