Anti-Inflammatory Activity of Sesquiterpene Lactones and Related Compounds

1979 ◽  
Vol 68 (5) ◽  
pp. 537-542 ◽  
Author(s):  
I.H. Hall ◽  
K.H. Lee ◽  
C.O. Starnes ◽  
Y. Sumida ◽  
R.Y. Wu ◽  
...  
Keyword(s):  
Sesquiterpene Lactones ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Related Compounds

ChemInform Abstract: Synthesis and Anti-Inflammatory Activity of 3,3a-Dihydro-2H,9H-isoxazolo[3,2-b]- [l,3]benzoxazin-9-ones and Related Compounds.

1977 ◽  
Vol 8 (32) ◽  
pp. no-no
Author(s):  
D. B. REISNER ◽  
B. J. LUDWIG ◽  
F. J. STIEFEL ◽  
S. GISTER ◽  
M. MEYER ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Related Compounds

scholarly journals Germacranolides from Carpesium divaricatum: Some New Data on Cytotoxic and Anti-Inflammatory Activity

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4644
Author(s):  
Natalia Kłeczek ◽  
Janusz Malarz ◽  
Barbara Gierlikowska ◽  
Łukasz Skalniak ◽  
Agnieszka Galanty ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Sesquiterpene Lactones ◽  
Inflammatory Activity ◽  
Human Neutrophils ◽  
Normal Prostate ◽  
Prostate Epithelial Cells ◽  
Tnf Α ◽  
P53 Status ◽  
Anti Inflammatory

Carpesium divaricatum Sieb. & Zucc., a traditional medicinal plant used as an inflammation-relieving remedy, is a rich source of terpenoids. At least 40 germacrane-type sesquiterpene lactones, representatives of four different structural groups, were isolated from the plant. Cytotoxicity against cancer cells in vitro is the most frequently described biological activity of the compounds. However, little is known about the selectivity of the cytotoxic effect. The anti-inflammatory activity of the germacranolides is also poorly documented. The objective of the present study was to assess the cytotoxic activity of selected C. divaricatum germacranolides-derivatives of 4,5,8,9-tetrahydroxy-3-oxo-germacran-6,12-olide towards cancer and normal cell lines (including cells of different p53 status). Moreover, to assess the anti-inflammatory effect of the compounds, the release of four proinflammatory cytokines/chemokines (IL-1β, IL-8, TNF-α and CCL2) by lipopolysaccharide-stimulated human neutrophils was measured by ELISA. The investigated sesquiterpene lactones demonstrated nonselective activity towards prostate cancer (Du145 and PC3) and normal prostate epithelial cells (PNT2) as well as against melanoma cells (A375 and HTB140) and keratinocytes (HaCaT). Cytotoxic activity against osteosarcoma cells was independent of their p53 status. In sub-cytotoxic concentrations (0.5–2.5 µM) the studied compounds significantly decreased cytokine/chemokine release by lipopolysaccharide-stimulated human leukocytes.

Potent anti-inflammatory activity of sesquiterpene lactones from Neurolaena lobata (L.) R. Br. ex Cass., a Q’eqchi’ Maya traditional medicine

2013 ◽  
Vol 92 ◽  
pp. 122-127 ◽  
Author(s):  
Brendan Walshe-Roussel ◽  
Christine Choueiri ◽  
Ammar Saleem ◽  
Muhammd Asim ◽  
Federico Caal ◽  
...  
Keyword(s):  
Traditional Medicine ◽  
Sesquiterpene Lactones ◽  
Inflammatory Activity ◽  
Anti Inflammatory

scholarly journals Antimicrobial, Anti-Inflammatory, Antiparasitic, and Cytotoxic Activities ofLaennecia confusa

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
María G. Martínez Ruiz ◽  
Melissa Richard-Greenblatt ◽  
Zaida N. Juárez ◽  
Yossef Av-Gay ◽  
Horacio Bach ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Leishmania Donovani ◽  
Sesquiterpene Lactones ◽  
Chloroform Extract ◽  
Inflammatory Activity ◽  
Cytotoxic Activities ◽  
Chemical Analyses ◽  
Antiparasitic Activity ◽  
Anti Inflammatory ◽  
Chloroform Methanol

The current paper investigated the potential benefit of the traditional Mexican medicinal plantLaennecia confusa(Cronquist) G. L. Nesom (Asteraceae). Fractions from the hexane, chloroform, methanol, and aqueous extracts were analyzed for antibacterial, antifungal, anti-inflammatory, and antiparasitic activities. The antimicrobial activity of the extracts and fractions was assessed on bacterial and fungal strains, in addition to the protozoaLeishmania donovani, using a microdilution assay. The propensity of the plant's compounds to produce adverse effects on human health was also evaluated using propidium iodine to identify damage to human macrophages. The anti-inflammatory activity of the extracts and fractions was investigated by measuring the secretion of interleukin-6. Chemical analyses demonstrated the presence of flavonoids, cyanogenic and cardiotonic glycosides, saponins, sesquiterpene lactones, and triterpenes in the chloroform extract. A number of extracts and fractions show antibacterial activity. Of particular interest is antibacterial activity againstStaphylococcus aureusand its relative methicillin-resistant strain, MRSA. Hexanic and chloroformic fractions also exhibit antifungal activity and two extracts and the fraction CE 2 antiparasitic activity againstLeishmania donovani. All bioactive extracts and fractions assayed were also found to be cytotoxic to macrophages. In addition, the hexane and methane extracts show anti-inflammatory activity by suppressing the secretion of interleukine-6.

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