Rapid, Stability-Indicating, High-Pressure Liquid Chromatographic Determination of Theophylline, Guaifenesin, and Benzoic Acid in Liquid and Solid Pharmaceutical Dosage Forms

1979 ◽  
Vol 68 (4) ◽  
pp. 530-532 ◽  
Author(s):  
D.R. Heidemann
1983 ◽  
Vol 66 (2) ◽  
pp. 284-286
Author(s):  
Thomas D Macy ◽  
Andrew Loh

Abstract A high pressure liquid chromatographic (HPLC) method has been developed to determine monensin in feed premixes. The method is simple and rapid. Monensin is extracted with methanol-water and determined in the extracting solution by HPLC. Average recovery for monensin from a 13.2% premix sample was 103% (coefficient of variation (CV), 2.6%) by HPLC and compares with the value of 100% (CV, 3.4%) obtained by the turbidimetric bioassay method.


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