Effect of Alpha Tocopherol (vitamin E) Deficiency on Intestinal Transport of Passively Absorbed Drugs

1976 ◽  
Vol 65 (3) ◽  
pp. 344-349 ◽  
Author(s):  
Mahasen M. Meshali ◽  
Charles H. Nightingale
Keyword(s):  
Vitamin E ◽  
Intestinal Transport ◽  
Alpha Tocopherol ◽  
Vitamin E Deficiency

scholarly journals A Case of Ataxia with Isolated Vitamin E Deficiency Initially Diagnosed as Friedreich’s Ataxia

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Michael Bonello ◽  
Partha Ray
Keyword(s):  
Vitamin E ◽  
Friedreich’S Ataxia ◽  
Friedreich's Ataxia ◽  
Alpha Tocopherol ◽  
Vitamin E Deficiency ◽  
Appropriate Treatment ◽  
Progressive Ataxia ◽  
Progressive Cerebellar Ataxia ◽  
Autosomal Recessive Condition ◽  
Neurological Features

Ataxia with isolated vitamin E deficiency (AVED) is a rare autosomal recessive condition that is caused by a mutation in the alpha tocopherol transfer protein gene. It is almost indistinguishable clinically from Friedreich’s ataxia but with appropriate treatment its devastating neurological features can be prevented. Patients can present with a progressive cerebellar ataxia, pyramidal spasticity, and evidence of a neuropathy with absent deep tendon reflexes. It is important to screen for this condition on initial evaluation of a young patient presenting with progressive ataxia and it should be considered in patients with a long standing ataxia without any diagnosis in view of the potential therapeutics and genetic counselling. In this case report we present a patient who was initially diagnosed with Friedreich’s ataxia but was later found to have AVED.

.ALPHA.-Tocopherol Transfer Protein and Familial Vitamin E Deficiency.

1996 ◽  
Vol 45 (5) ◽  
pp. 425-434
Author(s):  
Hiroyuki ARAI ◽  
Makoto ARITA ◽  
Keizo INOUE
Keyword(s):  
Vitamin E ◽  
Alpha Tocopherol ◽  
Vitamin E Deficiency ◽  
Transfer Protein

scholarly journals 84. THE EFFECTS OF VITAMIN E DEFICIENCY ON SMALL INTESTINAL TRANSPORT FUNCTION

1987 ◽  
Vol 22 (1) ◽  
pp. 110-110
Author(s):  
M Sato ◽  
M Goss-Sampson ◽  
D P R Muller ◽  
P J Mllla
Keyword(s):  
Vitamin E ◽  
Intestinal Transport ◽  
Transport Function ◽  
Vitamin E Deficiency ◽  
Small Intestinal

scholarly journals Aflatoxin B1 albumin adducts in plasma and aflatoxin M1 in urine are associated with plasma concentrations of vitamins A and E

2010 ◽  
Vol 80 (6) ◽  
pp. 355-368 ◽  
Author(s):  
Francis A. Obuseh ◽  
Pauline E. Jolly ◽  
Yi Jiang ◽  
Faisal M.B. Shuaib ◽  
John Waterbor ◽  
...  
Keyword(s):  
Vitamin E ◽  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Plasma Concentrations ◽  
Multivariable Analysis ◽  
Alpha Tocopherol ◽  
Aflatoxin M1 ◽  
Vitamin E Deficiency ◽  
Cross Sectional ◽  
Virus Surface

Background: Although aflatoxin exposure has been associated with micronutrient deficiency in animals, there are few investigations on the effects of aflatoxin exposure on micronutrient metabolism in humans. Objective: To examine the relationship between aflatoxin B1 (AFB1) albumin adducts (AF-ALB) in plasma and the aflatoxin M1 (AFM1) metabolite in urine and plasma concentrations of retinol (vitamin A) and alpha-tocopherol (vitamin E) in Ghanaians. Methods: A cross-sectional study of 147 adult participants was conducted. Blood and urine samples were tested for aflatoxin and vitamins A and E levels. Results: Multivariable analysis showed that participants with high AF-ALB (>= 0.80 pmol/mg albumin) had increased odds of having vitamin A deficiency compared to those with lower AF-ALB [Odds Ratio (OR) = 2.61; CI = 1.03 - 6.58; p = 0.04]. Participants with high AF-ALB also showed increased odds of having vitamin E deficiency but this was not statistically significant (OR = 2.4; CI = 0.96 - 6.05; p = 0.06). Conversely, those with higher AFM1 values had a statistically nonsignificant reduced odds of having vitamin A deficiency (OR = 0.31; CI = 0.09 - 1.02; p = 0.05) and a statistically significant reduced odds of having vitamin E deficiency (OR = 0.31; CI = 0.10 - 0.97; p = 0.04). Participants with high AF-ALB or high AFM1 (>= 437.95 pg/dL creatinine) were almost 6 times more likely to be hepatitis B virus surface antigen (HBsAg)-positive (OR = 5.88; CI = 1.71 - 20.14; p = 0.005) and (OR = 5.84; CI = 1.15 - 29.54; p = 0.03) respectively. Conclusions: These data indicate that aflatoxin may modify plasma micronutrient status. Thus, preventing aflatoxin exposure may reduce vitamin A and E deficiencies.

scholarly journals Impaired discrimination between stereoisomers of alpha-tocopherol in patients with familial isolated vitamin E deficiency.

1993 ◽  
Vol 34 (2) ◽  
pp. 201-210
Author(s):  
MG Traber ◽  
RJ Sokol ◽  
A Kohlschütter ◽  
T Yokota ◽  
DP Muller ◽  
...  
Keyword(s):  
Vitamin E ◽  
Alpha Tocopherol ◽  
Vitamin E Deficiency

scholarly journals Impaired ability of patients with familial isolated vitamin E deficiency to incorporate alpha-tocopherol into lipoproteins secreted by the liver.

1990 ◽  
Vol 85 (2) ◽  
pp. 397-407 ◽  
Author(s):  
M G Traber ◽  
R J Sokol ◽  
G W Burton ◽  
K U Ingold ◽  
A M Papas ◽  
...  
Keyword(s):  
Vitamin E ◽  
Alpha Tocopherol ◽  
Vitamin E Deficiency ◽  
Impaired Ability

scholarly journals A progressive neurological syndrome associated with an isolated Vitamin E deficiency

1984 ◽  
Vol 11 (S4) ◽  
pp. 561-564 ◽  
Author(s):  
P. Laplante ◽  
M. Vanasse ◽  
J. Michaud ◽  
G. Geoffroy ◽  
P. Brochu
Keyword(s):  
Vitamin E ◽  
Neurological Deficit ◽  
Clinical Picture ◽  
Underlying Disease ◽  
Alpha Tocopherol ◽  
Lower Limbs ◽  
Gait Ataxia ◽  
Vibration Sense ◽  
Vitamin E Deficiency ◽  
Neurological Syndrome

AbstractSeveral authors have recently reported a neurological disorder associated with chronic vitamin E deficiency in man. Except in one patient, this deficiency has always been secondary to an underlying disease resulting in lipid malabsorption. We report a second case of such a neurological syndrome in a patient in whom vitamin E deficiency was an isolated finding.The clinical picture in our patient was characterized by a diffuse muscle weakness most prominent distally and in the lower limbs, generalized areflexia, a decrease in proprioception and vibration sense and slight limb and gait ataxia. His condition improved on alpha tocopherol therapy so that it is very likely that vitamin E deficiency is responsible for his neurological deficit.Since in our patient as well as in several other reported cases this condition has been treatable, it is important that this syndrome be recognized in children presenting a suggestive clinical picture even if they do not have lipid malabsorption.

Vitamin E treatment of weaner sheep. I. The effect of vitamin E supplements on plasma α-tocopherol concentrations, liveweight and wool production in penned or grazing sheep

1996 ◽  
Vol 47 (6) ◽  
pp. 853 ◽  
Author(s):  
JM Fry ◽  
MC McGrath ◽  
M Harvey ◽  
F Sunderman ◽  
GM Smith ◽  
...  
Keyword(s):  
Vitamin E ◽  
Plasma Concentrations ◽  
Fibre Diameter ◽  
Alpha Tocopherol ◽  
Vitamin E Deficiency ◽  
Wool Production ◽  
Vitamin E Acetate ◽  
Economic Justification ◽  
Grazing Sheep ◽  
Selenium Supplements

Effect of vitamin E supplements on liveweight gain and wool production, and their effectiveness in increasing plasma alpha -tocopherol concentrations and preventing nutritional myopathy was investigated. Commercial preparations were compared in pen and grazing experiments in the first part of the study. In a pen experiment, 3 different treatments, intramuscular oily injection, oral drench and dried supplement added to feed, were compared; in grazing sheep, intramuscular oily injection and oral drench were compared. The intramuscular oily injection was slow to increase the plasma concentrations of alpha -tocopherol in pen experiments and did not prevent vitamin E deficiency and development of subclinical myopathy in grazing experiments. Oral treatments increased plasma alpha -tocopherol concentrations in the pen experiment; though repeated oral drench did not increase plasma alpha -tocopherol in the grazing experiment, the development of subclinical nutritional myopathy was prevented. Aqueous preparations of vitamin E and the effect of selenium supplements in grazing sheep were studied in the second part of the study. Aqueous injections of 2000 mg of vitamin E acetate by intramuscular and subcutaneous routes in December and February were successful in rapidly increasing and maintaining plasma alpha -tocopherol concentrations in grazing weaner sheep. Injections of aqueous emulsions of vitamin E acetate could be the most useful preventative treatment for nutritional myopathy if problems of tissue damage can be overcome. None of the vitamin E supplements increased liveweight gain in any of the experiments, and there was no increase in wool quantity or quality in any of the grazing experiments. When selenium and vitamin E supplementation were compared, selenium-supplemented sheep had greater wool length and fibre diameter over summer-autumn than vitamin E-treated or control sheep. Vitamin E supplements are expensive; unless flocks are susceptible to vitamin E-responsive myopathy, it is suggested that there is little economic justification for using vitamin E as a supplement over the summer.

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