Positional Isomer of the Muscle Relaxant Dantrolene

1975 ◽  
Vol 64 (6) ◽  
pp. 1047 ◽  
Author(s):  
Thomas J. Schwan ◽  
K.O. Ellis
Keyword(s):  
Muscle Relaxant ◽  
Positional Isomer

Glacial Acetic Acid Catalyzed Synthesis, Physicochemical and Biological Evaluation of Benzodiazepines as Potent CNS Agents

2019 ◽  
Vol 19 (2) ◽  
pp. 146-151
Author(s):  
Vipin Kumar ◽  
Shweta Verma ◽  
Sushil Kumar
Keyword(s):  
Skeletal Muscle ◽  
Muscle Relaxant ◽  
Treated Group ◽  
Biological Evaluation ◽  
Log P ◽  
Control Group ◽  
Skeletal Muscle Relaxant ◽  
Benzodiazepine Derivatives ◽  
Chloro Group ◽  
Muscle Relaxant Activity

Background: Approach for green chemistry for chemical synthesis is found to be very efficient as it makes the reaction more easily, less tedious, maximize desired products and minimize by-products. Materials & Methods: Utilizing this approach 1, 5-benzodiazepines and its derivatives have been synthesized and evaluated for skeletal muscle and antianxiety activity. 1, 5-benzodiazepine derivatives have attracted great attention due to its diversity of pharmacological activities and its application in heterocyclic synthesis and medicines. The target compounds were synthesized by first reacting o-phenylenediamine with acetophenone to yield 1, 5-benzodiazepines. In the next step the NH of 1, 5-benzodiazepines were chloroacetylated and then the chloro group was substituted with different anilines. The structures were confirmed on the basis of their TLC, IR, 1H NMR and CHN elemental studies. The physicochemical parameters were determined for BBB penetration through online software. Results: The Log P values of the compounds tested showed that compounds have the potential to be CNS active. The compounds were evaluated for the skeletal muscle relaxant activity and antianxiety activity. It was investigated that 1, 5-benzodiazepines derivatives possess significant differences between control group and treated group. Conclusion: Among these derivatives, the compound bearing chloro group possesses the highest skeletal muscle relaxant and antianxiety activity.

scholarly journals Central muscle relaxant effects of diazepam

1970 ◽  
Vol 9 (5) ◽  
pp. 481-484 ◽  
Author(s):  
R.D. Hudson ◽  
Mary K. Wolpert
Keyword(s):  
Muscle Relaxant

Propofol/Alfentanil for Rapid Intravenous Induction and Tracheal Intubation without Muscle Relaxant in Children

1994 ◽  
Vol 81 (SUPPLEMENT) ◽  
pp. A1328 ◽  
Author(s):  
R. M. Spear ◽  
A. Rodarte ◽  
J. Y. Waldman ◽  
M. A. Flynn
Keyword(s):  
Tracheal Intubation ◽  
Muscle Relaxant

Role of extracellular calcium and calmodulin in prolactin secretion induced by hyposmolarity, thyrotropin-releasing hormone, and high K+ in GH4C1 cells

1990 ◽  
Vol 123 (2) ◽  
pp. 218-224 ◽  
Author(s):  
Xiangbing Wang ◽  
Noriyuki Sato ◽  
Monte A. Greer ◽  
Susan E. Greer ◽  
Staci McAdams
Keyword(s):  
Smooth Muscle ◽  
Muscle Relaxant ◽  
Prolactin Secretion ◽  
Thyrotropin Releasing Hormone ◽  
Dependent Manner ◽  
Cell Toxicity ◽  
High K ◽  
Dose Dependent ◽  
Smooth Muscle Relaxant

Abstract. The mechanism by which 30% medium hyposmolarity induces PRL secretion by GH4C1 cells was compared with that induced by 100 nmol/l TRH or 30 mmol/l K+. Removing medium Ca2+, blocking Ca2+ channels with 50 μmol/l verapamil, or inhibiting calmodulin activation with 20 μmol/l trifluoperazine, 10 μmol/l chlorpromazine or 10 μmol/l pimozide almost completely blocked hyposmolarity-induced secretion. The smooth muscle relaxant, W-7, which is believed relatively specific in inhibiting the Ca2+-calmodulin interaction, depressed hyposmolarity-induced PRL secretion in a dose-dependent manner (r = −0.991, p<0.01 ). The above drugs also blocked or decreased high K+-induced secretion, but had much less effect on TRH-induced secretion. Secretion induced by TRH, hyposmolarity, or high K+ was optimal at pH 7.3-7.65 and was significantly depressed at pH 6.0 or 8.0, indicating that release of hormone induced by all 3 stimuli is due to an active cell process requiring a physiologic extracellular pH and is not produced by nonspecific cell toxicity. The data suggest hyposmolarity and high K+ may share some similarities in their mechanism of stimulating secretion, which is different from that of TRH.

Tracheal intubation without muscle relaxant after induction with remifentanil, S-ketamine and propofol

2004 ◽  
Vol 21 (Supplement 32) ◽  
pp. 11-12
Author(s):  
S. Demirbilek ◽  
T. Togal ◽  
N. Gulhas ◽  
Z. Ozpolat ◽  
Z. Dogan ◽  
...  
Keyword(s):  
Tracheal Intubation ◽  
Muscle Relaxant
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