Determination of Ascorbic Acid in Pharmaceutical Dosage Forms Based on Oxidation at the Tubular Carbon Electrode

1972 ◽  
Vol 61 (8) ◽  
pp. 1301-1303 ◽  
Author(s):  
William D. Mason ◽  
Thomas D. Gardner ◽  
James T. Stewart
Keyword(s):  
Ascorbic Acid ◽  
Dosage Forms ◽  
Carbon Electrode ◽  
Pharmaceutical Dosage Forms

Amperometric Determination of Propantheline Bromide in a Flowing Stream at the Glassy Carbon Electrode

1985 ◽  
Vol 68 (2) ◽  
pp. 165-167
Author(s):  
Mumtaz H Shah ◽  
James T Stewart
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Dosage Forms ◽  
Carbon Electrode ◽  
Amperometric Determination ◽  
Pharmaceutical Dosage Forms ◽  
Amperometric Method ◽  
Flowing Stream ◽  
Propantheline Bromide

Abstract University of Georgia, College of Pharmacy, Department of Medicinal Chemistry, Athens, GA 30602 A flow-injection method is presented for the determination of propantheline bromide, based on electrochemical oxidation at the glassy carbon electrode. The amperometric method can determine propantheline bromide in the presence of phenobarbital, commonly found in its combination dosage forms. The procedure is stability-indicating for propantheline when an ether extraction of the dosage form is done before amperometric detection. At the electrode potential of + 1400 mV, the calibration curve is linear in the 2-16 p.g/mL concentration range, and minimum detectability is 20 ng (signal-to-noise ratio of 2). When applied to the analysis of propantheline bromide in selected pharmaceutical dosage forms, the method shows good accuracy and precision. Although automation was not used in this study, the method could readily be incorporated in automated systems because it uses the technique of continuous analysis in a flowing stream

Amperometric Determination of Phenazopyridine Hydrochloride in a Flowing Stream at the Glassy Carbon Electrode

1985 ◽  
Vol 68 (6) ◽  
pp. 1207-1209 ◽  
Author(s):  
Fathalla Belal
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Reference Electrode ◽  
Dosage Forms ◽  
Automated System ◽  
Carbon Electrode ◽  
Amperometric Determination ◽  
Pharmaceutical Dosage Forms ◽  
Flowing Stream

Abstract A flow-injection method is described for the determination of phenazopyridine hydrochloride, based on electrochemical oxidation at the glassy carbon electrode. The suggested method is highly specific and can be used to determine phenazopyridine HC1 in the presence of most drugs commonly found in pharmaceutical dosage forms or administered therapeutically. Applying a constant potential of +950 mV vs Ag/AgCl/3.5M KCI reference electrode, the calibration curve was linear in the 1-30 μg/mL range, with minimum detectability of 0.2 ng (signal-to-noise ratio 2). Good accuracy and precision were obtained when the method was applied to some dosage forms containing phenazopyridine HC1. Although automation was not used in this study, an automated system could be incorporated because the method uses the technique of continuous analysis in a flowing stream.

Spectrophotometric Determination of Alendronate Sodium by using Sodium-1,2-Naphthoquinone-4-Sulphonate

2012 ◽  
Vol 4 (4) ◽  
pp. 1563-1568
Author(s):  
Sagar Suman Panda ◽  
Ravi Kumar B V V ◽  
D Patanaik
Keyword(s):  
Spectrophotometric Method ◽  
Absorption Maximum ◽  
Dosage Form ◽  
Dosage Forms ◽  
Alendronate Sodium ◽  
Colored Complex ◽  
Pharmaceutical Dosage Forms ◽  
Recovery Study ◽  
Assay Conditions

A simple, precise and accurate spectrophotometric method was developed for analysis of the osteoporesis drug alendronate sodium (ALS). The method is based on reaction of the drug with sodium-1,2-naphthoquinone-4-sulphonate (NQS) in presence of alkali to form a brown colored complex giving absorption maximum at 525 nm. The drug obeyed Beer’s law in the range of 5-70 µg/ml with a correlation coefficient of 0.999. The LOD and LOQ values are 1.7 µg/ml and 5.0 µg/ml, respectively. The average recoveries for recovery study were found to be in the range of 99.37%-100.46%. The R.S.D. values for intraday and inter-day precision were found to be 0.48 and 0.62, respectively. The optimized assay conditions were applied successfully for determination of ALS in pharmaceutical dosage forms. No interference was observed from the excipients present in the dosage form. The method is statistically validated as per the ICH requirements.  

Electroanalytical Methods for Determination of Calcium Channel Blockers

2019 ◽  
Vol 15 (3) ◽  
pp. 207-218 ◽  
Author(s):  
Fatma Ağın
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blocker ◽  
Heart Diseases ◽  
Dosage Forms ◽  
Channel Blockers ◽  
Electroanalytical Methods ◽  
Pharmaceutical Dosage Forms ◽  
Ischemic Heart Diseases

Background:Calcium Channel Blockers (CCBs) are widely used in the treatment of cardiovascular and ischemic heart diseases in recent years. They treat arrhythmias by reducing cardiac cycle contraction and also benefit ischemic heart diseases. Electroanalytical methods are very powerful analytical methods used in the pharmaceutical industry because of the determination of therapeutic agents and/or their metabolites in clinical samples at extremely low concentrations (10-50 ng/ml). The purpose of this review is to gather electroanalytical methods used for the determination of calcium channel blocker drugs in pharmaceutical dosage forms and biological media selected mainly from current articles.Methods:This review mainly includes recent determination studies of calcium channel blockers by electroanalytical methods from pharmaceutical dosage forms and biological samples. The studies of calcium channel blockers electroanalytical determination in the literature were reviewed and interpreted.Results:There are a lot of studies on amlodipine and nifedipine, but the number of studies on benidipine, cilnidipine, felodipine, isradipine, lercanidipine, lacidipine, levamlodipine, manidipine, nicardipine, nilvadipine, nimodipine, nisoldipine, nitrendipine, diltiazem, and verapamil are limited in the literature. In these studies, DPV and SWV are the most used methods. The other methods were used less for the determination of calcium channel blocker drugs.Conclusion:Electroanalytical methods especially voltammetric methods supply reproducible and reliable results for the analysis of the analyte. These methods are simple, more sensitive, rapid and inexpensive compared to the usually used spectroscopic and chromatographic methods.

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