Structure-Activity Relations in Organophosphorus-Inhibited Acetylcholinesterase Reactivators II: Methiodides of Hydroxyimino Derivatives of 1-Pyridyl-2-phenylethanes

1969 ◽  
Vol 58 (7) ◽  
pp. 857-860 ◽  
Author(s):  
Palmarisa Franchetti ◽  
Mario Grifantini ◽  
Sante Martelli
Keyword(s):  
Structure Activity ◽  
Structure Activity Relations ◽  
Derivatives Of ◽  
Acetylcholinesterase Reactivators

Structure-activity relations in cephalosporins prepared from penicillins. 1. 7.beta.-Acylamino derivatives of 3-benzyl- and 3-(3-pyridylmethyl)ceph-3-em-4-carboxylic acids

1977 ◽  
Vol 20 (8) ◽  
pp. 1082-1085 ◽  
Author(s):  
Edward G. Brain ◽  
A. John Eglington ◽  
John H. C. Nayler ◽  
Neal F. Osborne ◽  
Michael J. Pearson ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Structure Activity ◽  
Structure Activity Relations ◽  
Derivatives Of

Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Review

2021 ◽  
Vol 21 ◽  
Author(s):  
Ravinder Sharma ◽  
Pooja A. Chawla ◽  
Viney Chawla ◽  
Rajeev Verma ◽  
Nandita Nawal ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Protease Inhibitor ◽  
Medicinal Chemistry ◽  
Membered Ring ◽  
Present Review ◽  
Biological Profile ◽  
3C Protease ◽  
Structure Activity ◽  
Derivatives Of ◽  
Heterocyclic Moiety

Abstract: A sizeable proportion of currently marketed drugs come from heterocycles. The heterocyclic moiety 5-pyrazolone is well known five membered ring containing nitrogen. Derivatives of this wonder nucleus have exhibited activities as diverse as antimicrobial, anti-inflammatory, analgesic, antidepressant, anticonvulsant, antidiabetic, antihyperlipidemic, antiviral, antitubercular, antioxidant, anticancer and antiviral including action against severe acute respiratory syndrome (SARS) or 3C protease inhibitor. A number of drugs based on this motif have already made it to the market. Standard texts and literature on medicinal chemistry cite different approaches for the synthesis of 5-pyrazolones. The present review provides an insight view to 5-pyrazolone synthesis, their biological profile and structure activity relationship studies.

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