Pilot Plant Vacuum Drying of Tablet Excipients

1965 ◽  
Vol 54 (7) ◽  
pp. 1050-1054 ◽  
Author(s):  
Charles J. Swartz ◽  
William L. Suydam
1970 ◽  
Vol 53 (1) ◽  
pp. 56-62 ◽  
Author(s):  
E.F. Schoppet ◽  
N.C. Aceto ◽  
J.C. Craig ◽  
H.I. Sinnamon

Author(s):  
S. W. Hui ◽  
T. P. Stewart

Direct electron microscopic study of biological molecules has been hampered by such factors as radiation damage, lack of contrast and vacuum drying. In certain cases, however, the difficulties may be overcome by using redundent structural information from repeating units and by various specimen preservation methods. With bilayers of phospholipids in which both the solid and fluid phases co-exist, the ordering of the hydrocarbon chains may be utilized to form diffraction contrast images. Domains of different molecular packings may be recgnizable by placing properly chosen filters in the diffraction plane. These domains would correspond to those observed by freeze fracture, if certain distinctive undulating patterns are associated with certain molecular packing, as suggested by X-ray diffraction studies. By using an environmental stage, we were able to directly observe these domains in bilayers of mixed phospholipids at various temperatures at which their phases change from misible to inmissible states.


Author(s):  
R. C. Moretz ◽  
D. F. Parsons

Short lifetime or total absence of electron diffraction of ordered biological specimens is an indication that the specimen undergoes extensive molecular structural damage in the electron microscope. The specimen damage is due to the interaction of the electron beam (40-100 kV) with the specimen and the total removal of water from the structure by vacuum drying. The lower percentage of inelastic scattering at 1 MeV makes it possible to minimize the beam damage to the specimen. The elimination of vacuum drying by modification of the electron microscope is expected to allow more meaningful investigations of biological specimens at 100 kV until 1 MeV electron microscopes become more readily available. One modification, two-film microchambers, has been explored for both biological and non-biological studies.


1952 ◽  
Vol 44 (3) ◽  
pp. 449-449
Author(s):  
C DeWitt ◽  
M Livingood ◽  
K Miller
Keyword(s):  

2016 ◽  
Vol 15 (3) ◽  
pp. 251-259
Author(s):  
Shreedhar Devkota ◽  
◽  
Jin Oh Jo ◽  
Dong Lyong Jang ◽  
Young Jin Hyun ◽  
...  

2012 ◽  
Vol 7 (0) ◽  
pp. 2405035-2405035
Author(s):  
George H. NEILSON ◽  
David A. GATES ◽  
Charles E. KESSEL ◽  
Jonathan E. MENARD ◽  
Stewart C. PRAGER ◽  
...  
Keyword(s):  

2004 ◽  
Vol 90 (9) ◽  
pp. 734-738 ◽  
Author(s):  
Takashi ARIMA ◽  
Yukihiro KUBOTA ◽  
Kenji KATO ◽  
Makoto MATSUURA ◽  
Hirotaka NAKAI ◽  
...  
Keyword(s):  

2006 ◽  
Vol 14 (2) ◽  
pp. 630-633 ◽  
Author(s):  
W. Fuchs ◽  
T. Wirthensohn ◽  
W. Wittmann ◽  
P. Schoeberl

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