Comparison Study of Alkyl Boronic Acids with Boric Acid

1962 ◽  
Vol 51 (3) ◽  
pp. 290-291 ◽  
Author(s):  
Stephen M. Sleight ◽  
Muriel C. Vincent
Keyword(s):  
Boric Acid ◽  
Boronic Acids ◽  
Comparison Study

scholarly journals Boric acid and boronic acids inhibition of pigeonpea urease

2006 ◽  
Vol 21 (4) ◽  
pp. 467-470 ◽  
Author(s):  
K. Ravi Charan Reddy ◽  
Arvind M. Kayastha
Keyword(s):  
Boric Acid ◽  
Boronic Acids

scholarly journals Proteus mirabilis urease. Partial purification and inhibition by boric acid and boronic acids

1988 ◽  
Vol 250 (3) ◽  
pp. 917-920 ◽  
Author(s):  
J M Breitenbach ◽  
R P Hausinger
Keyword(s):  
Boric Acid ◽  
Proteus Mirabilis ◽  
Ph Dependence ◽  
Competitive Inhibitor ◽  
Boronic Acids ◽  
Urinary Stones ◽  
Partial Purification ◽  
Pka Values

Urease was purified 800-fold and partially characterized from Proteus mirabilis, the predominant microorganism associated with urinary stones. Boric acid is a rapid reversible competitive inhibitor of urease. The pH-dependence of inhibition exhibited pKa values of 6.25 and 9.3, where the latter value is probably due to the inherent pKa of boric acid. Three boronic acids also were shown to inhibit urease competitively.

Mechanism of Action of Potent Boron-Containing Antifungals

2020 ◽  
Vol 16 (5) ◽  
pp. 552-556
Author(s):  
Costa Arvanitis ◽  
Trevor Rook ◽  
Ian Macreadie
Keyword(s):  
Boric Acid ◽  
Mechanism Of Action ◽  
Boronic Acids ◽  
Boron Compounds ◽  
Inhibit Protein Synthesis ◽  
Trade Name ◽  
Antifungal Action ◽  
Underlying Mechanisms ◽  
Rate Limiting ◽  
Fungistatic Effect

Background: Boron is unusual to organic chemists, yet boron interacts greatly with organic biochemicals and has considerable bioactivity, especially as an antifungal and insecticide. The bestknown bioactive boron compounds are boric acid, its salt borax, and the closely related boronic acids. A newcomer is tavaborole (trade name Kerydin), recently developed and approved in 2014 for topical treatment of onychomycosis, a fungal infection of nails and the nail bed. It is timely to review the literature and explore the way in which these compounds may work. Methods: The focus of this review is to examine peer-reviewed literature relating to boric acid, boronic acid and tavaborole, the most bioactive boron-containing compounds, and the evidence for their proposed mechanism of antifungal action. In parallel with the literature, we have examined the fungistatic effects of boric acid on yeast. Results: All three compounds are reported to inhibit protein synthesis but their mechanism of action may differ. Chemistry studies indicate an interaction of boric acid with ribose and ribose-containing moieties such as NAD. In this review, we discuss the activity of boric acid and use both tavaborole and the boronic acids to exemplify the similar underlying mechanisms used. As there is a push to develop new antimicrobials, we demonstrate that boric acid’s fungistatic effect is alleviated with ribose, NAD and tryptophan. Conclusion: We speculate that boric acid inhibits yeast growth by disrupting tryptophan synthesis as well as downstream NAD, a rate limiting co-enzyme, essential for cellular function.

Boric Acid

1889 ◽  
Vol 27 (690supp) ◽  
pp. 11021-11021
Keyword(s):  
Boric Acid
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