Stress Tolerance of Antibody–Poly(Amino Acid) Complexes for Improving the Stability of High Concentration Antibody Formulations

2015 ◽  
Vol 104 (8) ◽  
pp. 2457-2463 ◽  
Author(s):  
Shunsuke Izaki ◽  
Takaaki Kurinomaru ◽  
Kenji Handa ◽  
Tomoaki Kimoto ◽  
Kentaro Shiraki
Keyword(s):  
Amino Acid ◽  
Stress Tolerance ◽  
High Concentration ◽  
Amino Acid Complexes ◽  
The Stability

Olefin−Amino Acid Complexes of Platinum(II). 2. NMR Study of the Effect of Olefin Structure on the Stability and on the Stereoselectivity of Binding for η2-Coordinated Prochiral Olefins

1997 ◽  
Vol 36 (3) ◽  
pp. 284-290 ◽  
Author(s):  
Luther E. Erickson ◽  
Peter Hayes ◽  
Joanna J. Hooper ◽  
Kevin F. Morris ◽  
Sally A. Newbrough ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Complexes ◽  
Nmr Study ◽  
The Stability

Potentiometric study of enantioselective effects in α-amino acid complexes of copper(II)

1985 ◽  
Vol 104 (1) ◽  
pp. 63-67 ◽  
Author(s):  
I.L. Ulanovski ◽  
A.A. Kurganov ◽  
V.A. Davankov
Keyword(s):  
Amino Acid ◽  
Potentiometric Study ◽  
Amino Acid Complexes

scholarly journals Marine Exopolysaccharide Complexed With Scandium Aimed as Theranostic Agents

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1143 ◽  
Author(s):  
Mattia Mazza ◽  
Cyrille Alliot ◽  
Corinne Sinquin ◽  
Sylvia Colliec-Jouault ◽  
Pascal E. Reiller ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Light Scattering ◽  
Molar Mass ◽  
Field Flow Fractionation ◽  
High Concentration ◽  
New Class ◽  
Free Ion ◽  
Theranostic Agents ◽  
The Stability ◽  
Drug Reference

(1) Background: Exopolysaccharide (EPS) derivatives, produced by Alteromonas infernus bacterium, showed anti-metastatic properties. They may represent a new class of ligands to be combined with theranostic radionuclides, such as 47Sc/44Sc. The goal of this work was to investigate the feasibility of such coupling. (2) Methods: EPSs, as well as heparin used as a drug reference, were characterized in terms of molar mass and dispersity using Asymmetrical Flow Field-Flow Fractionation coupled to Multi-Angle Light Scattering (AF4-MALS). The intrinsic viscosity of EPSs at different ionic strengths were measured in order to establish the conformation. To determine the stability constants of Sc with EPS and heparin, a Free-ion selective radiotracer extraction (FISRE) method has been used. (3) Results: AF4-MALS showed that radical depolymerization produces monodisperse EPSs, suitable for therapeutic use. EPS conformation exhibited a lower hydrodynamic volume for the highest ionic strengths. The resulting random-coiled conformation could affect the complexation with metal for high concentration. The LogK of Sc-EPS complexes have been determined and showing that they are comparable to the Sc-Hep. (4) Conclusions: EPSs are very promising to be coupled with the theranostic pair of scandium for Nuclear Medicine.

scholarly journals Synthesis, Characterization, and Non-Covalent Interactions of Palladium(II)-Amino Acid Complexes

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4331
Author(s):  
David B. Hobart ◽  
Michael A. G. Berg ◽  
Hannah M. Rogers ◽  
Joseph S. Merola
Keyword(s):  
Amino Acid ◽  
High Resolution Mass Spectrometry ◽  
Resonance Spectroscopy ◽  
Spectroscopic Techniques ◽  
X Ray Diffraction ◽  
Amino Acid Complexes ◽  
Acetone Water ◽  
Square Planar ◽  
Non Covalent Interactions ◽  
Covalent Interactions

The reaction of palladium(II) acetate with acyclic amino acids in acetone/water yields square planar bis-chelated palladium amino acid complexes that exhibit interesting non-covalent interactions. In all cases, complexes were examined by multiple spectroscopic techniques, especially HRMS (high resolution mass spectrometry), IR (infrared spectroscopy), and 1H NMR (nuclear magnetic resonance) spectroscopy. In some cases, suitable crystals for single crystal X-ray diffraction were able to be grown and the molecular structure was obtained. The molecular geometries of the products are discussed. Except for the alanine complex, all complexes incorporate water molecules into the extended lattice and exhibit N-H···O and/or O···(HOH)···O hydrogen bonding interactions. The non-covalent interactions are discussed in terms of the extended lattice structures exhibited by the structures.

Film Elasticity and Film Stabilization in Firefighting Foam Stabilized by Solid Particles

2017 ◽  
Vol 744 ◽  
pp. 346-349
Author(s):  
Xiu Juan Li ◽  
Rui Song Guo ◽  
Min Zhao
Keyword(s):  
Life Time ◽  
Liquid Films ◽  
Thin Liquid Films ◽  
Solid Particles ◽  
High Concentration ◽  
Hydration Effect ◽  
Fixed Area ◽  
The Stability ◽  
Hydration Layers ◽  
Hydration Forces

The structure of the thin liquid films determines the stability of foams and emulsions. In this work the bubbles stretched length with different hollow SiO2 particles concentration is measured when the foam has been stilled for different time. The results show that the bubbles stretched length is longer than that of bubbles when the foam is free of hollow SiO2 particles even when the foam has been stilled for 500mins. The bubbles stretched length increases with increasing the concentration of hollow SiO2 particles. A strong hydration effect leaves a large volume of hydration layers on the solid particles surfaces in aqueous solutions. The water in hydration layers can help the film keep a certain thickness. The existence of hydration forces leads that two particles cannot be too close each other. The high concentration surfactant limited in the fixed area helps the film keep good elasticity. Therefore the film has a long life time with compatible thickness and elasticity and the three-phrase foam is upper stable.

Ternary chromium(III)-nucleotide-amino acid complexes III. L-Glutamic acid derivatives

1989 ◽  
Vol 165 (1) ◽  
pp. 131-137 ◽  
Author(s):  
M. Vicens ◽  
J.J. Fiol ◽  
A. Terron ◽  
V. Moreno
Keyword(s):  
Amino Acid ◽  
Glutamic Acid ◽  
Amino Acid Complexes ◽  
Glutamic Acid Derivatives

Equilibrium constants of metal amino acid complexes

Polyhedron ◽  
1990 ◽  
Vol 9 (5) ◽  
pp. 665-668 ◽  
Author(s):  
F. Rey ◽  
J.M. Antelo ◽  
F. Arce ◽  
F.J. Penedo
Keyword(s):  
Amino Acid ◽  
Equilibrium Constants ◽  
Amino Acid Complexes

Synthesis and properties of Zn(II)-salicylidene amino acid complexes

1987 ◽  
Vol 118 (11) ◽  
pp. 1289-1296 ◽  
Author(s):  
M. R. Mahmoud ◽  
S. A. El-Gyar ◽  
A. Shaker ◽  
A. M. Abdel-Mawgoud
Keyword(s):  
Amino Acid ◽  
Amino Acid Complexes
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