A Paradigm Shift in Pharmacokinetic–Pharmacodynamic (PKPD) Modeling: Rule of Thumb for Estimating Free Drug Level in Tissue Compared with Plasma to Guide Drug Design

2015 ◽  
Vol 104 (7) ◽  
pp. 2359-2368 ◽  
Author(s):  
Patrick Poulin
Keyword(s):  
Drug Design ◽  
Paradigm Shift ◽  
Drug Level ◽  
Free Drug ◽  
Rule Of Thumb ◽  
Pkpd Modeling ◽  
Modeling Rule

scholarly journals Epileptogenesis, Ictogenesis and the Design of Future Antiepileptic Drugs

2003 ◽  
Vol 30 (1) ◽  
pp. 4-7 ◽  
Author(s):  
Donald F. Weaver
Keyword(s):  
Drug Design ◽  
Drug Development ◽  
Antiepileptic Drug ◽  
Antiepileptic Drugs ◽  
Paradigm Shift ◽  
Drug Of Choice ◽  
The Future ◽  
Conceptual Evolution

ABSTRACT:There is still no medical cure for epilepsy. Clinical epileptology is in need of a “paradigm shift” when it comes to the continuing development of therapeutics. An important first step in this conceptual evolution is differentiating between the notions of ictogenesis and epileptogenesis. All traditional therapeutics are anti-ictogenic, not antiepileptogenic. The future of antiepileptic drug development lies in the discovery of antiepileptogenics. Just as aspirin is not the drug of choice for meningitis, an anticonvulsant is not the drug of choice for epilepsy. Drug design for epilepsy needs to discover a penicillin, not more aspirins.

On the Paradigm Shift Towards Multitarget Selective Drug Design

2008 ◽  
Vol 4 (2) ◽  
pp. 76-90 ◽  
Author(s):  
Nigus Dessalew ◽  
Workalemahu Mikre
Keyword(s):  
Drug Design ◽  
Paradigm Shift

Filtration for Free Drug Level Monitoring

1984 ◽  
Vol 6 (1) ◽  
pp. 67-76 ◽  
Author(s):  
R H. Levy ◽  
P. N. Friel ◽  
L. M. Linthicum ◽  
L. Colin ◽  
K. Koch ◽  
...  
Keyword(s):  
Drug Level ◽  
Free Drug ◽  
Drug Level Monitoring ◽  
Level Monitoring

Potential Applications of Free Drug Level Monitoring in Cardiovascular Therapy†

1984 ◽  
Vol 9 (Supplement 1) ◽  
pp. 79-83 ◽  
Author(s):  
Raymond L. Woosley ◽  
Lyle A. Siddoway ◽  
Katherine Thompson ◽  
Irene Cerskus ◽  
Dan M. Roden
Keyword(s):  
Drug Level ◽  
Free Drug ◽  
Cardiovascular Therapy ◽  
Potential Applications ◽  
Drug Level Monitoring ◽  
Level Monitoring

A Possible Paradigm Shift in Thinking About Thinking

1985 ◽  
Vol 30 (1) ◽  
pp. 17-17
Author(s):  
Marion Perlmutter
Keyword(s):  
Paradigm Shift

The Postindustrial Paradigm Shift: From Roles to Relationships

1994 ◽  
Vol 39 (2) ◽  
pp. 197-198
Author(s):  
Raymond T. Garza
Keyword(s):  
Paradigm Shift
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