scholarly journals Effects of Syringe Material and Silicone Oil Lubrication on the Stability of Pharmaceutical Proteins

2015 ◽  
Vol 104 (2) ◽  
pp. 527-535 ◽  
Author(s):  
Elena Krayukhina ◽  
Kouhei Tsumoto ◽  
Susumu Uchiyama ◽  
Kiichi Fukui
Keyword(s):  
Silicone Oil ◽  
Oil Lubrication ◽  
Pharmaceutical Proteins ◽  
The Stability

Preparation of Cross-Linked Cellulase Aggregate and Application to Cool Finishing of Cotton Fabric

2021 ◽  
Vol 8 (3) ◽  
pp. 1-7
Author(s):  
Gang Bai ◽  
Bingbing Feng ◽  
Yanchun Liu ◽  
Shujiao Dai
Keyword(s):  
Water Vapor ◽  
Cotton Fabric ◽  
Silicone Oil ◽  
Air Permeability ◽  
Kinetic Friction ◽  
Capillary Effect ◽  
Bending Rigidity ◽  
Moisture Permeability ◽  
Treated Sample ◽  
The Stability

Cellulase was immobilized by cross-linked enzyme aggregation to improve the stability of cellulase. The prepared cross-linked cellulase aggregates (CLCAs) and ice silicone oil were used for the cool finishing of cotton fabric. The results showed that the CLCAs extended the cellulase stability compared to free cellulase. The surface softness, smoothness, moisture permeability, and air permeability of the cotton fabric increased after CLCAs and ice silicone oil treatment. Shearing rigidity of the treated sample was 0.44 cN/(cm·deg), bending rigidity was 0.0069 cN cm, and the drape coefficient was 29.3%. Coefficient of kinetic friction of the treated sample was 0.186. The capillary effect of the treated fabric was 12.1 cm/(30 min). Air permeability was 354.3 L/(m2·s). Moisture penetrability was 3.912 g/(m2·d). The thermal and water-vapor resistance were 0.0194 m2·°C/W and 4.691 Pa·m2/W, respectively.

scholarly journals Effect of H2O on the Pressure-Induced Amorphization of Hydrated AlPO4-17

Molecules ◽  
2019 ◽  
Vol 24 (16) ◽  
pp. 2864 ◽  
Author(s):  
Frederico G. Alabarse ◽  
Boby Joseph ◽  
Andrea Lausi ◽  
Julien Haines
Keyword(s):  
Pressure Range ◽  
Silicone Oil ◽  
Structural Response ◽  
Microporous Material ◽  
X Ray ◽  
Guest Species ◽  
Order Of Magnitude ◽  
Diamond Anvil ◽  
The Stability

The incorporation of guest species in zeolites has been found to strongly modify their mechanical behavior and their stability with respect to amorphization at high pressure (HP). Here we report the strong effect of H2O on the pressure-induced amorphization (PIA) in hydrated AlPO4-17. The material was investigated in-situ at HP by synchrotron X-ray powder diffraction in diamond anvil cells by using non- and penetrating pressure transmitting media (PTM), respectively, silicone oil and H2O. Surprisingly, in non-penetrating PTM, its structural response to pressure was similar to its anhydrous phase at lower pressures up to ~1.4 GPa, when the amorphization was observed to start. Compression of the structure of AlPO4-17 is reduced by an order of magnitude when the material is compressed in H2O, in which amorphization begins in a similar pressure range as in non-penetrating PTM. The complete and irreversible amorphization was observed at ~9.0 and ~18.7 GPa, respectively, in non- and penetrating PTM. The present results show that the insertion of guest species can be used to strongly modify the stability of microporous material with respect to PIA, by up to an order of magnitude.

An experimental study on the effects of temperature and magnetic field strength on the magnetorheological fluid stability and MR effect

Soft Matter ◽  
2015 ◽  
Vol 11 (22) ◽  
pp. 4453-4460 ◽  
Author(s):  
Yahya Rabbani ◽  
Mahshid Ashtiani ◽  
Seyed Hassan Hashemabadi
Keyword(s):  
Magnetic Field ◽  
Experimental Study ◽  
Field Strength ◽  
Rheological Properties ◽  
Carbonyl Iron ◽  
Silicone Oil ◽  
Magnetorheological Fluid ◽  
Effects Of Temperature ◽  
The Stability ◽  
Mr Effect

In this study, the stability and rheological properties of a suspension of carbonyl iron microparticles (CIMs) in silicone oil were investigated within a temperature range of 10 to 85 °C.

scholarly journals Tribological Properties of V-Shaped Surface Texture under Oil Lubrication Condition

2019 ◽  
Vol 37 (2) ◽  
pp. 401-406
Author(s):  
Yuanbo Wu ◽  
Xuefeng Yang ◽  
Shouren Wang ◽  
Jian Cheng ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Friction Coefficient ◽  
Tribological Properties ◽  
Turbulence Intensity ◽  
Friction And Wear ◽  
Testing Machine ◽  
Wear Testing ◽  
Oil Lubrication ◽  
Oil Film ◽  
Texture Model ◽  
The Stability

In order to study the tribological properties of V-shaped texture under oil lubrication conditions, the loading force and speed are selected as the influencing factors, each factor selected six levels. Experimental study on friction and wear of V-shaped texture with ring arrangement is finished by MMG-10 Multifunctional Friction and Wear Testing Machine, and the data of the experimental results are analyzed by using Matlab. The results show that there is a near linear relationship between the friction coefficient and the loading force and velocity. The relationship between the friction coefficient and the loading force and velocity can be expressed by a functional equation. The loading force has a greater influence on the friction coefficient than the speed. The SEM images of the post-test specimens show that the main weared zone of the V-shaped texture is the tip part. Create a single V-shaped texture model with Solidworks and use CFD to divide the mesh into the Fluent solution. According to the pressure distribution cloud diagram and the turbulence intensity cloud diagram, the stability of the oil film is improved due to the enhanced fluidity of the oil film and the small change in the oil pressure. The tip portion is also the region with a large turbulence intensity value. The improvement of the stability of the oil film is the key to reduce the friction coefficient of the V-shaped texture when the loading force increases.

scholarly journals Experimental Study of the Static and Dynamic Characteristics of a Long (L/D = 0.75) Labyrinth Annular Seal Operating Under Two-Phase (Liquid/Gas) Conditions

2019 ◽  
Vol 141 (11) ◽  
Author(s):  
Hari Shrestha ◽  
Dara W. Childs ◽  
Dung L. Tran ◽  
Min Zhang
Keyword(s):  
Volume Fraction ◽  
Silicone Oil ◽  
Dynamic Stiffness ◽  
Labyrinth Seal ◽  
Radial Clearance ◽  
Labyrinth Seals ◽  
Two Phase ◽  
Annular Seal ◽  
The Stability ◽  
Gas Volume

AbstractA two-phase annular-seal stand at the Turbomachinery Laboratory of Texas A&M University is utilized to experimentally investigate a labyrinth seal operating under two-phase flow conditions (a mixture of silicone oil and air). A long labyrinth seal (length-to-diameter ratio L/D = 0.75, diameter D = 114.729 mm, and radial clearance Cr = 0.213 mm) is tested at a supply pressure of 62 bars-g with inlet gas volume fraction GVFi ranging from 90 to 100%. Tests were conducted at three pressure ratios PR (0.3, 0.4, 0.5), three rotating speeds (5, 10, 15 krpm), six GVFi (90%, 92%, 94%, 96%, 98%, and 100%), and three inlet-preswirl inserts, namely, zero, medium, and high. Specifically, the ratio between the fluid's circumferential velocity and the shaft surface's velocity are in ranges of 0.0–0.2, 0.5–1.6, and 0.5–2.7 for the zero, medium, and high preswirls respectively. The direct dynamic stiffness KΩ is negative. As GVFi decreases (more liquid), KΩ becomes more negative for the zero preswirl. The effect of changing GVFi on KΩ for the medium and high preswirls is not as clear as for the zero preswirl. For the zero preswirl, as GVFi decreases, the cross-coupled dynamic stiffness kΩ and direct damping C damping increase. However, the effective damping Ceff values converge to almost the same positive value for higher frequencies. Hence, there is no significant effect of change in GVFi for the zero preswirl. For the high preswirl, as GVFi decreases, kΩ decreases and C increases. As GVFi decreases, Ceff becomes less negative and eventually becomes positive for frequencies higher than Ωc. This result indicates that at certain frequencies, the presence of liquid can make the labyrinth seals with high preswirl more stable. For the seal tested, a compressor running at 15 krpm and PR (ratio of seal exit pressure and seal inlet pressure) = 0.5 with the first critical speed of 7500 rpm (125 Hz) would experience an increase in stability with presence of liquid in the flow stream for the medium and high preswirls. However, for the range of GVFi considered here, if swirl brakes are used in a compressor application to reduce the preswirl, there would be no impact of liquid presence on the stability of the compressor. Concerning static measurements, leakage rate m˙ increases with decreases in GVFi but remains unchanged with increasing preswirl.

Stability of the Interface Between Two Immiscible Liquids in a Model Eye Subject to Saccadic Motion

2021 ◽  
Author(s):  
Ru Wang ◽  
Jheng-han Tsai ◽  
Martin Snead ◽  
Philip Alexander ◽  
D. Ian Wilson
Keyword(s):  
Weber Number ◽  
3D Model ◽  
Silicone Oil ◽  
Dynamics Simulation ◽  
Saccade Amplitude ◽  
Computational Fluid Dynamics Simulation ◽  
Immiscible Liquids ◽  
Bulk Fluid ◽  
The Stability ◽  
Particle Imaging

Abstract The interface between silicone oil and saline layers in a 3D model of the eye chamber was studied under different eye-like saccadic motions in order to determine the stability of the interface and propensity for emulsification in the bulk. The effect of level of fill; saccade amplitude, angular velocity, latency time; and orientation were investigated experimentally in spherical flasks with internal diameters 10, 28 and 40 mm, as well as a 28 mm diameter flask with an indent replicating the lens or the presence of a buckle. The deformation of the interface was quantified in terms of the change in its length in 2-D images. The deformation increased with Weber number, We, and was roughly proportional to We for We > 1. The presence of the lens gave rise to higher deformation near this feature. In both cases emulsification was not observed in either bulk fluid. The velocity profile in the spherical configuration was mapped using particle imaging velocimetry and is compared with an analytical solution and a short computational fluid dynamics simulation study. These confirm that the saccadic motion induces flow near the wall in the saline layer and significantly further into the chamber in the silicone oil. Surfactants soluble in the aqueous and oil phases reduced the interfacial tension, increasing deformation but did not lead to emulsification in the bulk.

Design of a four-bar latch mechanism and a shear-based rotary viscous damper for single-axis prosthetic knees

2021 ◽  
pp. 1-16
Author(s):  
V.N. Murthy Arelekatti ◽  
Nina T. Petelina ◽  
W. Brett Johnson ◽  
Matthew J. Major ◽  
Amos G. Winter, V
Keyword(s):  
Low Income ◽  
Knee Flexion ◽  
Silicone Oil ◽  
High Viscosity ◽  
Smooth Transition ◽  
Timely Initiation ◽  
Prosthetic Knee ◽  
Peak Knee ◽  
The Stability ◽  
Prosthetic Knees

Abstract With over 30 million people worldwide requiring assistive devices, there is a great need for affordable prosthetic technologies that can enable kinematics close to able-bodied gait. Passive prosthetic knees designed for low-income users have primarily focused on stability and affordability, often at the cost of the high biomechanical performance that is required to replicate able-bodied kinematics. We present the design and preliminary testing of two distinct mechanisms that are novel for passive prosthetic knee applications: the stability module and the damping module. These mechanisms are designed to enable users of single-axis, passive prostheses to walk with close to able-bodied kinematics on level-ground, specifically during the transition from the stance phase to the swing phase of the gait cycle. The stability module was implemented with a latch mounted on a virtual axis of a four-bar linkage, which can be engaged during early stance for stability and disengaged during late stance to initiate knee flexion. The damping module was implemented with a concentric stack of stationary and rotating pairs of plates that shear thin films of high-viscosity silicone oil. For preliminary user-centric validation, a prototype prosthetic knee with the stability module and two dampers (with varying damping coefficients) was tested on a single participant. The stability module enabled smooth transition from stance to swing with timely initiation of knee flexion. An increase in the damping coefficient was found to decrease the peak knee flexion close to the able-bodied range (58-70 deg).

Modified Tessari Tourbillon technique for making foam sclerotherapy with silicone-free syringes

2014 ◽  
Vol 30 (9) ◽  
pp. 614-617 ◽  
Author(s):  
Mark S Whiteley ◽  
Salil B Patel
Keyword(s):  
Silicone Oil ◽  
Small Diameter ◽  
Oil Lubrication ◽  
Foam Sclerotherapy ◽  
Sodium Tetradecyl Sulphate

The longevity of foam made using sodium tetradecyl sulphate and gas (air or a CO2:O2 mixture) is increased significantly if silicone-free syringes are used over the normal syringes containing silicone oil lubrication. However, the plungers in silicone-free syringes start sticking after several passages when making foam for sclerotherapy, preventing the smooth injection of the resulting foam. We describe a three syringe technique which allows foam to be made using the Tessari Tourbillon ‘three-way stopcock’ principle between two syringes, but with the foam ending up in a third syringe which has not undergone multiple passages of the plunger. This allows a smoother injection of the resultant foam, which is particularly useful when injecting small diameter veins under ultrasound control.

scholarly journals Development of a Magnetic Compound Fluid Rubber Stability Sensor and a Novel Production Technique via Combination of Natural, Chloroprene and Silicone Rubbers

Sensors ◽  
2019 ◽  
Vol 19 (18) ◽  
pp. 3901 ◽  
Author(s):  
Kunio Shimada ◽  
Ryo Ikeda ◽  
Hiroshige Kikura ◽  
Hideharu Takahashi
Keyword(s):  
Silicone Oil ◽  
Hot Water ◽  
Γ Irradiation ◽  
Combination Technique ◽  
Polymerization Behavior ◽  
Chloroprene Rubber ◽  
The Stability ◽  
Diene Rubbers ◽  
Silicone Rubbers ◽  
Highly Porous

Expanding on our previous report, we investigate the stability of a magnetic compound fluid (MCF) rubber sensor that was developed for a variety of engineering applications. To stabilize this sensor, we proposed a novel combination technique that facilitates the addition of dimethylpolysiloxane (PDMS) to natural rubber (NR)-latex or chloroprene rubber (CR)-latex using polyvinyl alcohol (PVA) by experimentally and theoretically investigating issues related to instability. This technique is one of several other novel combinations of diene and non-diene rubbers. Silicone oil or rubber with PDMS can be combined with NR-latex and CR-latex because of PVA’s emulsion polymerization behavior. In addition, owing to electrolytic polymerization based on the combination of PDMS and PVA, MCF rubber is highly porous and can be infiltrated in any liquid. Hence, the fabrication of novel intelligent rubbers using any intelligent fluid is feasible. By assembling infiltrated MCF rubber sheets and by conducting electrolytic polymerization of MCF rubber liquid with a hydrate using the adhesive technique as presented in a previous paper, it is possible to stabilize the MCF rubber sensor. This sensor is resistant to cold or hot water as well as γ-irradiation as shown in the previous report.

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