Development of ADA Against Recombinant Human Interferon Beta in Immune Tolerant Mice Requires Rapid Recruitment of CD4+ T Cells, Induces Formation of Germinal Centers but Lacks Susceptibility for (Most) Adjuvants

2015 ◽  
Vol 104 (2) ◽  
pp. 396-406 ◽  
Author(s):  
Grzegorz Kijanka ◽  
Melody Sauerborn ◽  
Louis Boon ◽  
Huub Schellekens ◽  
Vera Brinks
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Interferon Beta ◽  
Germinal Centers ◽  
Human Interferon ◽  
Immune Tolerant ◽  
Recombinant Human Interferon Beta

Immunogenicity of Recombinant Human Interferon Beta-1b in Immune-Tolerant Transgenic Mice Corresponds with the Biophysical Characteristics of Aggregates

2016 ◽  
Vol 36 (4) ◽  
pp. 247-257 ◽  
Author(s):  
Mohadeseh Haji Abdolvahab ◽  
Ahmad Fazeli ◽  
Andhyk Halim ◽  
Ahmad S. Sediq ◽  
Mohammad Reza Fazeli ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Interferon Beta ◽  
Human Interferon ◽  
Immune Tolerant ◽  
Recombinant Human Interferon Beta

scholarly journals Aggregated Recombinant Human Interferon Beta Induces Antibodies but No Memory in Immune-Tolerant Transgenic Mice

2010 ◽  
Vol 27 (9) ◽  
pp. 1812-1824 ◽  
Author(s):  
Miranda M. C. van Beers ◽  
Melody Sauerborn ◽  
Francesca Gilli ◽  
Vera Brinks ◽  
Huub Schellekens ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Interferon Beta ◽  
Human Interferon ◽  
Immune Tolerant ◽  
Recombinant Human Interferon Beta

scholarly journals Compromised Ox40 Function in Cd28-Deficient Mice Is Linked with Failure to Develop Cxc Chemokine Receptor 5–Positive Cd4 Cells and Germinal Centers

1999 ◽  
Vol 190 (8) ◽  
pp. 1115-1122 ◽  
Author(s):  
Lucy S.K. Walker ◽  
Adam Gulbranson-Judge ◽  
Sarah Flynn ◽  
Thomas Brocker ◽  
Chandra Raykundalia ◽  
...  
Keyword(s):  
T Cells ◽  
Fusion Protein ◽  
Chemokine Receptor ◽  
Germinal Center ◽  
Cd4 T Cells ◽  
Germinal Centers ◽  
Interleukin 4 ◽  
Cxc Chemokine ◽  
Germinal Center Formation

Mice rendered deficient in CD28 signaling by the soluble competitor, cytotoxic T lymphocyte–associated molecule 4–immunoglobulin G1 fusion protein (CTLA4-Ig), fail to upregulate OX40 expression in vivo or form germinal centers after immunization. This is associated with impaired interleukin 4 production and a lack of CXC chemokine receptor (CXCR)5 on CD4 T cells, a chemokine receptor linked with migration into B follicles. Germinal center formation is restored in CTLA4-Ig transgenic mice by coinjection of an agonistic monoclonal antibody to CD28, but this is substantially inhibited if OX40 interactions are interrupted by simultaneous injection of an OX40-Ig fusion protein. These data suggest that CD28-dependent OX40 ligation of CD4 T cells at the time of priming is linked with upregulation of CXCR5 expression, and migration of T cells into B cell areas to support germinal center formation.

Immunogenicity of Recombinant Human Interferon Beta Interacting with Particles of Glass, Metal, and Polystyrene

2012 ◽  
Vol 101 (1) ◽  
pp. 187-199 ◽  
Author(s):  
Miranda M.C. Van Beers ◽  
Francesca Gilli ◽  
Huub Schellekens ◽  
Theodore W. Randolph ◽  
Wim Jiskoot
Keyword(s):  
Interferon Beta ◽  
Human Interferon ◽  
Recombinant Human Interferon Beta ◽  
Glass Metal

Recombinant human interferon- in the treatment of condylomata acuminata

1997 ◽  
Vol 8 (10) ◽  
pp. 622-628 ◽  
Author(s):  
Wallace Dinsmore ◽  
Joe Jordan ◽  
Colm O'Mahony ◽  
John R W Harris ◽  
Alexander McMillan ◽  
...  
Keyword(s):  
Interferon Beta ◽  
Cytopathic Effect ◽  
Treatment Success ◽  
Condylomata Acuminata ◽  
Human Interferon ◽  
Partial Reduction ◽  
Benign Lesions ◽  
Previous Therapy ◽  
Patient Withdrawal ◽  
Recombinant Human Interferon Beta

The number of clinic consultations for condylomata acuminata (genital warts) has increased substantially during the last 30 years. Most infections produce benign lesions but a few types may be associated with cervical and penile cancers. Interferons (IFN) have shown antiviral properties to these infections and IFN- in particular has demonstrated a specific cytopathic effect in humans. A total of 124 patients with condylomata acuminata, the majority of whom had failed previous therapy, were treated intralesionally with either recombinant human interferon-beta 1a (r-hIFN--1a) or placebo. Up to 6 lesions were treated in each patient, and injections were made 3 times per week for a total of 9 injections. The patients were then followed up for 3 months. Efficacy assessments at all time points (day 19, week 6 and month 3) showed a clear advantage for the r-hIFN--1a interferon-beta treatment. Patients receiving rhIFN--1a showed a greater proportion of treatment success in terms of the complete or partial reduction (at least 50%) of the total area of the treated lesions. The treatment was also well tolerated. Headache, flu-like symptoms and asthenia were more common in patients receiving r-hIFN--1a, but these adverse events were generally mild in severity and rarely led to patient withdrawal. It was concluded that r-hIFN--1a has good efficacy in condylomata acuminata, and therefore presents a useful therapeutic alternative in this hard-to-treat condition.

scholarly journals Activated CD4 + T cells enter the splenic T‐cell zone and induce autoantibody‐producing germinal centers through bystander activation

2013 ◽  
Vol 44 (1) ◽  
pp. 93-102 ◽  
Author(s):  
David Banczyk ◽  
Kathrin Kalies ◽  
Lars Nachbar ◽  
Lars Bergmann ◽  
Philipp Schmidt ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
Germinal Centers ◽  
Bystander Activation ◽  
Cell Zone
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