Delivery of Drugs from Laminar Co-Extrudates Manufactured by a Solvent-Free Process at Room Temperature

2014 ◽  
Vol 103 (11) ◽  
pp. 3501-3510
Author(s):  
Gonçalo Oliveira ◽  
Martin A. Wahl ◽  
JoãO. F. Pinto
Keyword(s):  
Room Temperature ◽  
Solvent Free ◽  
Free Process

Dry mechanochemical synthesis of alane from LiH and AlCl3

2014 ◽  
Vol 170 ◽  
pp. 137-153 ◽  
Author(s):  
Ihor Z. Hlova ◽  
Shalabh Gupta ◽  
Jennifer F. Goldston ◽  
Takeshi Kobayashi ◽  
Marek Pruski ◽  
...  
Keyword(s):  
Solid State ◽  
Room Temperature ◽  
Reaction Pathway ◽  
Milling Process ◽  
Solvent Free ◽  
Aluminium Chloride ◽  
Rational Approach ◽  
Starting Mixture ◽  
Free Process ◽  
Temperature Programmed

A mechanochemical process for the synthesis of alane (AlH3) starting from lithium hydride (LiH) and aluminium chloride (AlCl3) at room temperature and the underlying reaction pathway have been studied. In contrast to a conventional process using the same two reactants dissolved in diethyl ether, our approach enables a solvent-free synthesis, thereby directly leading to adduct-free alane. The method described here is quick and efficient, resulting in the quantitative conversion of all aluminium in the starting mixture to alane. Both the intermediate compounds formed during the reaction and the final products have been characterized by powder X-ray diffraction, solid-state27Al NMR spectroscopy, and temperature programmed desorption analysis of the as-milled mixtures. We show that excess LiH in the starting mixture (with an optimal ratio of 9LiH : 1AlCl3) is essential for the formation and stability of Al–H bonds, initially in the form of alanates and, eventually, as alane. Further processing of this mixture, gradually adding AlCl3to reach the ideal 3LiH : 1AlCl3stoichiometry, appears to restrict the local accumulation of AlCl3during the ball-milling process, thereby preventing the formation of unstable intermediates that decompose to metallic Al and molecular hydrogen. We also demonstrate that under the milling conditions used, a moderate hydrogen pressure ofca.300 bar is required to suppress competing reactions that lead to the formation of metallic Al at room temperature. The identification of the reaction intermediates at each stage of the synthesis provides significant insight into the mechanism of this solid-state reaction, which may potentially afford a more rational approach toward the production of AlH3in a simple solvent-free process.

scholarly journals Sn(ii)-catalyzed β-citronellol esterification: a Brønsted acid-free process for synthesis of fragrances at room temperature

2015 ◽  
Vol 5 (2) ◽  
pp. 1261-1266 ◽  
Author(s):  
M. J. da Silva ◽  
A. A. Julio ◽  
K. T. dos Santos
Keyword(s):  
Acetic Acid ◽  
Room Temperature ◽  
Solvent Free ◽  
High Conversion ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Free Process ◽  
Solvent Free Conditions ◽  
Brönsted Acid

Simple SnCl2·2H2O was demonstrated to be able to catalyze β-citronellol esterification with acetic acid at room temperature under solvent-free conditions, achieving high conversion and ester selectivity (ca. 88% and 99%, respectively).

Preparation and Characterization of a Novel Room Temperature Dicationic Ionic Liquid and its Application in the Synthesis of Xanthenediones Under Solvent-Free Conditions

2018 ◽  
Vol 21 (8) ◽  
pp. 602-608 ◽  
Author(s):  
Zainab Ehsani-Nasab ◽  
Ali Ezabadi
Keyword(s):  
Ionic Liquid ◽  
Room Temperature ◽  
Reaction Times ◽  
Significant Loss ◽  
Solvent Free ◽  
Acidity Function ◽  
Efficient Catalyst ◽  
Solvent Free Conditions ◽  
Hammett Acidity Function ◽  
Dicationic Ionic Liquid

Aim and Objective: In the present work, 1, 1’-sulfinyldiethylammonium bis (hydrogen sulfate) as a novel room temperature dicationic ionic liquid was synthesized and used as a catalyst for xanthenediones synthesis. Material and Method: The dicationic ionic liquid has been synthesized using ethylamine and thionyl chloride as precursors. Then, by the reaction of [(EtNH2)2SO]Cl2 with H2SO4, [(EtNH2)2SO][HSO4]2 was prepared and after that, it was characterized by FT-IR, 1H NMR, 13C NMR as well as Hammett acidity function. This dicationic ionic liquid was used as a catalyst for the synthesis of xanthenediones via condensation of structurally diverse aldehydes and dimedone under solvent-free conditions. The progress of the reaction was monitored by thin layer chromatography (ethyl acetate/n-hexane = 3/7). Results: An efficient solvent-free method for the synthesis of xanthenediones has been developed in the presence of [(EtNH2)2SO][HSO4]2 as a powerful catalyst with high to excellent yields, and short reaction times. Additionally, recycling studies have demonstrated that the dicationic ionic liquid can be readily recovered and reused at least four times without significant loss of its catalytic activity. Conclusion: This new dicationic ionic liquid can act as a highly efficient catalyst for xanthenediones synthesis under solvent-free conditions.

scholarly journals Mechanically induced solvent-free esterification method at room temperature

RSC Advances ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 5080-5085
Author(s):  
Lei Zheng ◽  
Chen Sun ◽  
Wenhao Xu ◽  
Alexandr V. Dushkin ◽  
Nikolay Polyakov ◽  
...  
Keyword(s):  
Natural Products ◽  
Carboxylic Acids ◽  
Late Stage ◽  
Reaction Mechanisms ◽  
Room Temperature ◽  
Solvent Free ◽  
Mild Conditions

We have developed I2/KH2PO2 and KI/P(OEt)3 strategy syntheses of esters from carboxylic acids and alcohols through different reaction mechanisms. The advantages of present protocol: mild conditions and late-stage diversification of natural products.

Efficient Synthesis of Tetrahydrobenzo[b]pyrans under Solvent‐Free Conditions at Room Temperature

2006 ◽  
Vol 36 (16) ◽  
pp. 2363-2369 ◽  
Author(s):  
Liangce Rong ◽  
Xiaoyue Li ◽  
Haiying Wang ◽  
Daqing Shi ◽  
Shujiang Tu ◽  
...  
Keyword(s):  
Room Temperature ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
Solvent Free Conditions
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