scholarly journals Joint Feedback Analysis Modeling of Nonesterified Fatty Acids in Obese Zucker Rats and Normal Sprague–Dawley Rats after Different Routes of Administration of Nicotinic Acid

2014 ◽  
Vol 103 (8) ◽  
pp. 2571-2584 ◽  
Author(s):  
Sofia Tapani ◽  
Joachim Almquist ◽  
Jacob Leander ◽  
Christine Ahlström ◽  
Lambertus A. Peletier ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Nicotinic Acid ◽  
Zucker Rats ◽  
Sprague Dawley ◽  
Nonesterified Fatty Acids ◽  
Feedback Analysis ◽  
Routes Of Administration ◽  
Sprague Dawley Rats ◽  
Obese Zucker Rats

Effect of Genetic Obesity on Thermoregulatory Activity Responses to Inversion of the Light/Dark Cycle

2001 ◽  
Vol 2 (4) ◽  
pp. 249-256 ◽  
Author(s):  
Patricia A. Jarosz ◽  
Terry A. Lennie ◽  
Pamela J. Rowsey ◽  
Bonnie L. Metzger
Keyword(s):  
Total Activity ◽  
Zucker Rats ◽  
Sprague Dawley ◽  
Genetic Obesity ◽  
Temperature Rhythm ◽  
Sprague Dawley Rats ◽  
Pilot Work ◽  
Obese Zucker Rats ◽  
Reversal Temperature ◽  
Fatty Zucker Rat

In this pilot work, the authors compared the circadian rhythm responses of 3-month-old female fatty Zucker rats with those of lean Zucker rats and Sprague-Dawley rats to reversal of the light/dark (LD) cycle. Core temperature and spontaneous cage activity were continuously monitored by implanted microtelemetry devices prior to and for 5 days following complete LD cycle reversal. By the 5th day after LD reversal, temperature rhythm nadir had phase-advanced 10.5 hours in the lean Zucker rats, 10.8 hours in the Sprague-Dawley rats, and only 3.8 hours in the fatty Zucker rats. Similarly, total activity increased in lean Zucker rats and Sprague-Dawley rats after LD reversal but declined in the fatty Zucker rat during the same time. Results of this study show that obese Zucker rats displayed an impaired ability to reentrain circadian rhythms for temperature and activity when compared to lean Zucker rats and Sprague-Dawley rats. These findings suggest that dysfunction in the circadian pacemaker previously shown to manifest itself by 43 weeks of age in fatty Zucker rats may already be present at 3 months of age and suggest that altered thermoregulation may play a role in the development of obesity in this animal model of genetic obesity.

Weight reduction increases adipose but decreases cardiac LPL in reduced-obese Zucker rats

1991 ◽  
Vol 261 (2) ◽  
pp. E246-E251 ◽  
Author(s):  
D. H. Bessesen ◽  
A. D. Robertson ◽  
R. H. Eckel
Keyword(s):  
Adipose Tissue ◽  
Cardiac Muscle ◽  
Weight Reduction ◽  
Zucker Rats ◽  
Mrna Levels ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Obese Rats ◽  
Obese Zucker Rats ◽  
Coordinate Changes

Lipoprotein lipase (LPL) activity and mRNA levels were measured in cardiac muscle and adipose tissue from lean, obese, and weight-stable reduced-obese Zucker rats, both fasted and 2 h after feeding. Fasting epididymal fat LPL activity was substantially higher in obese rats relative to lean rats [6.9 vs. 0.2 nmol free fatty acid (FFA).10(6) cells-1.min-1; P = 0.0001], and was higher still in reduced-obese rats (15.7 nmol FFA.10(6) cells-1.min-1; P = 0.002). Adipose tissue LPL increased with feeding in all three groups. In marked contrast, fasting cardiac muscle LPL was lower in obese rats relative to lean (28.8 vs. 38.5 nmol FFA.g-1.min-1; P = 0.0064) and was lower still in reduced-obese rats (14.5 nmol FFA.g-1.min-1; P = 0.0001). LPL mRNA levels increased in adipose tissue along with enzyme activity; however, the magnitude of the changes were relatively small, suggesting that the primary regulatory steps are posttranslational. Weight reduction studies were also carried out in Sprague-Dawley rats with similar results. These studies show that sustained weight reduction results in coordinate changes in tissue-specific LPL, favoring delivery of lipoprotein triglyceride fatty acids to adipose tissue relative to cardiac muscle and the restoration of energy stores.

Feedback modeling of non-esterified fatty acids in obese Zucker rats after nicotinic acid infusions

2013 ◽  
Vol 40 (6) ◽  
pp. 623-638 ◽  
Author(s):  
Christine Ahlström ◽  
Tobias Kroon ◽  
Lambertus A. Peletier ◽  
Johan Gabrielsson
Keyword(s):  
Fatty Acids ◽  
Nicotinic Acid ◽  
Zucker Rats ◽  
Esterified Fatty Acids ◽  
Obese Zucker Rats

scholarly journals Milk fermented by Lactobacillus gasseri SBT2055 influences adipocyte size via inhibition of dietary fat absorption in Zucker rats

2008 ◽  
Vol 101 (5) ◽  
pp. 716-724 ◽  
Author(s):  
Essam M. Hamad ◽  
Masao Sato ◽  
Kazunori Uzu ◽  
Takeshi Yoshida ◽  
Seiichiro Higashi ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Dietary Fat ◽  
Zucker Rats ◽  
Fat Absorption ◽  
Adipocyte Size ◽  
Sprague Dawley ◽  
Lactobacillus Gasseri ◽  
Sprague Dawley Rats ◽  
Obese Zucker Rats ◽  
Dietary Fat Absorption

We have demonstrated previously that a diet containing skimmed milk (SM) fermented by Lactobacillus gasseri SBT2055 (LGSP) reduces adipocyte size in Sprague–Dawley rats. Two experiments were conducted to extend these observations in order to elucidate the mechanism involved. In experiment 1, lean and obese Zucker rats were fed a diet containing SM or LGSP for 4 weeks. The LGSP diet, compared with the SM diet, resulted in lowering of the mesenteric adipose tissue weight (23 %; P < 0·05), adipocyte sizes (28 %; P < 0·001) and serum leptin concentration (36 %; P < 0·05) in lean rats. Obese Zucker rats did not display such dietary effects. Only the number of smaller adipocytes was increased (P < 0·05) by the LGSP diet in the subcutaneous adipose tissue of obese rats. The LGSP diet significantly reduced the serum and hepatic cholesterol in rats. In addition, the LGSP diet led to an increased excretion of faecal fatty acids and total neutral faecal sterols in both rat strains. In experiment 2, Sprague–Dawley rats with permanent cannulation of the thoracic duct were fed either the SM or LGSP diets and their lymph was collected. The LGSP diet lowered the maximum transport rate of TAG and phospholipids. These results indicate that fermented milk regulates adipose tissue growth through inhibition at the stage of dietary fat absorption in lean Zucker rats.

scholarly journals Endocannabinoids May Mediate the Ability of (n-3) Fatty Acids to Reduce Ectopic Fat and Inflammatory Mediators in Obese Zucker Rats

2009 ◽  
Vol 139 (8) ◽  
pp. 1495-1501 ◽  
Author(s):  
Barbara Batetta ◽  
Mikko Griinari ◽  
Gianfranca Carta ◽  
Elisabetta Murru ◽  
Alessia Ligresti ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Inflammatory Mediators ◽  
Zucker Rats ◽  
Ectopic Fat ◽  
Obese Zucker Rats

scholarly journals The effects of polyunsaturated:saturated fatty acids ratios and peroxidisability index values of dietary fats on serum lipid profiles and hepatic enzyme activities in rats

2005 ◽  
Vol 94 (4) ◽  
pp. 526-532 ◽  
Author(s):  
Min Jeong Kang ◽  
Myoung Suk Shin ◽  
Jung Nan Park ◽  
Sang Sun Lee
Keyword(s):  
Fatty Acids ◽  
Enzyme Activities ◽  
Serum Lipid ◽  
Hdl Cholesterol ◽  
Thiobarbituric Acid ◽  
Dietary Fats ◽  
Thiobarbituric Acid Reactive Substance ◽  
Hepatic Enzyme ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Raising the dietary PUFA:saturated fatty acids (SFA) ratio has been recommended for the prevention of CVD. However, a high PUFA:SFA (P:S) ratio diet enhances oxidative stress because PUFA are highly susceptible to lipid peroxidation. Thus, we focused on the role of the dietary P:S ratio and peroxidisability index (PI) value on serum and liver tissue and investigated the effects of dietary P:S ratios (0·4, 1·0, and 4·8) with a fixed PI value (81) on serum lipid parameters and hepatic enzyme activities (experiment 1). To elucidate whether those phenomena were unique to the P:S ratio, we examined the effects of dietary PI values (36, 81, 126, and 217) with a constant P:S ratio (1·0) (experiment 2). Female Sprague–Dawley rats weighing 240–280 g were fed experimental diets for 4 weeks. When dietary PI value was maintained at 81, serum HDL-cholesterol (HDL-C) increased with increasing dietary P:S ratio. When the P:S ratio was fixed at 1·0, HDL-C was the lowest with mid–low PI (MLPI) (PI value of 81). In both experiments, serum LDL-cholesterol:HDL-C ratio kept in the range of 0–2. The hepatic superoxide dismutase, catalase, and glutathione peroxidase (GSH-Px) activities and thiobarbituric acid reactive substance (TBARS) concentrations were the highest in the lowest dietary P:S ratio group (experiment 1). GSH-Px, glutathione-S-transferase, and TBARS were the lowest in rats fed the MLPI diet (experiment 2). In conclusion, these results indicate that a P:S ratio of 1·0–1·5 and a PI value of 80–90 in the diet are within a favourable range to reduce the risk of CVD.

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