scholarly journals The Impact of Hot Melt Extrusion and Spray Drying on Mechanical Properties and Tableting Indices of Materials Used in Pharmaceutical Development

2013 ◽  
Vol 102 (10) ◽  
pp. 3604-3613 ◽  
Author(s):  
Raman Iyer ◽  
Shridhar Hegde ◽  
Yu-E. Zhang ◽  
James Dinunzio ◽  
Dharmendra Singhal ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Spray Drying ◽  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Pharmaceutical Development ◽  
Tableting Indices ◽  
Materials Used ◽  
The Impact ◽  
Hot Melt

scholarly journals Influence of Carbamazepine Dihydrate on the Preparation of Amorphous Solid Dispersions by Hot Melt Extrusion

Pharmaceutics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 379 ◽  
Author(s):  
Xiangyu Ma ◽  
Felix Müller ◽  
Siyuan Huang ◽  
Michael Lowinger ◽  
Xu Liu ◽  
...  
Keyword(s):  
Energy State ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Hot Melt Extrusion ◽  
Water Soluble ◽  
Melt Extrusion ◽  
Amorphous Solid Dispersions ◽  
Water Soluble Drugs ◽  
The Impact ◽  
Hot Melt

Amorphous solid dispersions (ASDs) are commonly used in the pharmaceutical industry to improve the dissolution and bioavailability of poorly water-soluble drugs. Hot melt extrusion (HME) has been employed to prepare ASD based products. However, due to the narrow processing window of HME, ASDs are normally obtained with high processing temperatures and mechanical stress. Interestingly, one-third of pharmaceutical compounds reportedly exist in hydrate forms. In this study, we selected carbamazepine (CBZ) dihydrate to investigate its solid-state changes during the dehydration process and the impact of the dehydration on the preparation of CBZ ASDs using a Leistritz micro-18 extruder. Various characterization techniques were used to study the dehydration kinetics of CBZ dihydrate under different conditions. We designed the extrusion runs and demonstrated that: 1) the dehydration of CBZ dihydrate resulted in a disordered state of the drug molecule; 2) the resulted higher energy state CBZ facilitated the drug solubilization and mixing with the polymer matrix during the HME process, which significantly decreased the required extrusion temperature from 140 to 60 °C for CBZ ASDs manufacturing compared to directly processing anhydrous crystalline CBZ. This work illustrated that the proper utilization of drug hydrates can significantly improve the processability of HME for preparing ASDs.

Hot melt extrusion versus spray drying: hot melt extrusion degrades albendazole

2016 ◽  
Vol 43 (5) ◽  
pp. 797-811 ◽  
Author(s):  
Soraya Hengsawas Surasarang ◽  
Justin M. Keen ◽  
Siyuan Huang ◽  
Feng Zhang ◽  
James W. McGinity ◽  
...  
Keyword(s):  
Spray Drying ◽  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Hot Melt

Taste masking of isoniazid by hot melt extrusion and spray drying – A comparative study

2016 ◽  
Vol 511 (2) ◽  
pp. 1142
Author(s):  
Alison Keating ◽  
Duncan Craig ◽  
Catherine Tuleu ◽  
Claire Forbes ◽  
Barry Aldous ◽  
...  
Keyword(s):  
Comparative Study ◽  
Spray Drying ◽  
Hot Melt Extrusion ◽  
Taste Masking ◽  
Melt Extrusion ◽  
Hot Melt

scholarly journals The impact of hot-melt extrusion on the tableting behaviour of polyvinyl alcohol

2016 ◽  
Vol 498 (1-2) ◽  
pp. 254-262 ◽  
Author(s):  
W. Grymonpré ◽  
W. De Jaeghere ◽  
E. Peeters ◽  
P. Adriaensens ◽  
J.P. Remon ◽  
...  
Keyword(s):  
Polyvinyl Alcohol ◽  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
The Impact ◽  
Hot Melt

scholarly journals Hot-Melt Extrusion Process Fluctuations and Their Impact on Critical Quality Attributes of Filaments and 3D-Printed Dosage Forms

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 511 ◽  
Author(s):  
Hanna Ponsar ◽  
Raphael Wiedey ◽  
Julian Quodbach
Keyword(s):  
Process Analysis ◽  
Hot Melt Extrusion ◽  
Quality Attributes ◽  
Dosage Forms ◽  
Melt Extrusion ◽  
Critical Quality Attributes ◽  
Filament Diameter ◽  
3D Printed ◽  
The Impact ◽  
Hot Melt

Fused deposition modeling (FDMTM) is a 3D-printing technology of rising interest for the manufacturing of customizable solid dosage forms. The coupling of hot-melt extrusion with FDMTM is favored to allow the production of pharma-grade filaments for the printing of medicines. Filament diameter consistency is a quality of great importance to ensure printability and content uniformity of 3D-printed drug delivery systems. A systematical process analysis referring to filament diameter variations has not been described in the literature. The presented study aimed at a process setup optimization and rational process analysis for filament fabrication related to influencing parameters on diameter inhomogeneity. In addition, the impact of diameter variation on the critical quality attributes of filaments (mechanical properties) and uniformity of mass of printed drug-free dosage forms was investigated. Process optimization by implementing a winder with a special haul-off unit was necessary to obtain reliable filament diameters. Subsequently, the optimized setup was used for conduction of rational extrusion analysis. The results revealed that an increased screw speed led to diameter fluctuations with a decisive influence on the mechanical resilience of filaments and mass uniformity of printed dosage forms. The specific feed load was identified as a key parameter for filament diameter consistency.

Improvement in mechanical properties of grafted polylactic acid composite fibers via hot melt extrusion

2014 ◽  
Vol 35 (9) ◽  
pp. 1792-1797 ◽  
Author(s):  
Michael A. Gunning ◽  
Luke M. Geever ◽  
John A. Killion ◽  
John G. Lyons ◽  
Clement L. Higginbotham
Keyword(s):  
Mechanical Properties ◽  
Polylactic Acid ◽  
Hot Melt Extrusion ◽  
Composite Fibers ◽  
Melt Extrusion ◽  
Hot Melt
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