Trehalose Limits BSA Aggregation in Spray-Dried Formulations at High Temperatures: Implications in Preparing Polymer Implants for Long-Term Protein Delivery

2013 ◽  
Vol 102 (8) ◽  
pp. 2655-2666 ◽  
Author(s):  
Karthikan Rajagopal ◽  
Joseph Wood ◽  
Benjamin Tran ◽  
Thomas W. Patapoff ◽  
Thierry Nivaggioli
Keyword(s):  
High Temperatures ◽  
Protein Delivery ◽  
Polymer Implants ◽  
Bsa Aggregation ◽  
Spray Dried

Physiological and morphological effects of climate change

2019 ◽  
pp. 120-133 ◽  
Author(s):  
Andrew E. McKechnie
Keyword(s):  
Climate Change ◽  
Body Mass ◽  
High Temperatures ◽  
Arid Zone ◽  
Future Research ◽  
Long Term Effects ◽  
Adaptation To Climate Change ◽  
Heat Events

The direct impacts of higher temperatures on birds are manifested over timescales ranging from minutes and hours to years and decades. Over short timescales, acute exposure to high temperatures can lead to hyperthermia or dehydration, which among arid-zone species occasionally causes catastrophic mortality events. Over intermediate timescales of days to weeks, high temperatures can have chronic sub-lethal effects via body mass loss or reduced nestling growth rates, negatively affecting sev eral fitness components. Long-term effects of warming manifested over years to decades involve declining body mass or changes in appendage size. Key directions for future research include elucidating the role of phenotypic plasticity and epigenetic processes in avian adaptation to climate change, examining the role of stress pathways in mediating responses to heat events, and understanding the consequences of higher temperatures for species that traverse hot regions while migrating.

scholarly journals BN/SiBCN light-leakage-proof coatings of silica optical fiber for long term sensors at high temperatures

2020 ◽  
Author(s):  
Xin'gang LUAN ◽  
Xinming XU ◽  
Rong YU ◽  
Qiqi ZHANG ◽  
Sam ZHANG ◽  
...  
Keyword(s):  
Optical Fiber ◽  
High Temperatures ◽  
Silica Optical Fiber

scholarly journals Long-Term Physical (In)Stability of Spray-Dried Amorphous Drugs: Relationship with Glass-Forming Ability and Physicochemical Properties

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 425 ◽  
Author(s):  
Edueng ◽  
Bergström ◽  
Gråsjö ◽  
Mahlin
Keyword(s):  
Glass Transition ◽  
Transition Temperature ◽  
Glass Transition Temperature ◽  
Physicochemical Properties ◽  
Physical Stability ◽  
Glass Forming Ability ◽  
Melt Quenching ◽  
Glass Forming ◽  
Spray Dried

This study shows the importance of the chosen method for assessing the glass-forming ability (GFA) and glass stability (GS) of a drug compound. Traditionally, GFA and GS are established using in situ melt-quenching in a differential scanning calorimeter. In this study, we included 26 structurally diverse glass-forming drugs (i) to compare the GFA class when the model drugs were produced by spray-drying with that when melt-quenching was used, (ii) to investigate the long-term physical stability of the resulting amorphous solids, and (iii) to investigate the relationship between physicochemical properties and the GFA of spray-dried solids and their long-term physical stability. The spray-dried solids were exposed to dry (<5% RH) and humid (75% RH) conditions for six months at 25 °C. The crystallization of the spray-dried solids under these conditions was monitored using a combination of solid-state characterization techniques including differential scanning calorimetry, Raman spectroscopy, and powder X-ray diffraction. The GFA/GS class assignment for 85% of the model compounds was method-dependent, with significant differences between spray-drying and melt-quenching methods. The long-term physical stability under dry condition of the compounds was predictable from GFA/GS classification and glass transition and crystallization temperatures. However, the stability upon storage at 75% RH could not be predicted from the same data. There was no strong correlation between the physicochemical properties explored and the GFA class or long-term physical stability. However, there was a slight tendency for compounds with a relatively larger molecular weight, higher glass transition temperature, higher crystallization temperature, higher melting point and higher reduced glass transition temperature to have better GFA and better physical stability. In contrast, a high heat of fusion and entropy of fusion seemed to have a negative impact on the GFA and physical stability of our dataset.

Study of the scale formed on super 304H boiler tube steels after long-term steam oxidation at high temperatures

2018 ◽  
Vol 146 ◽  
pp. 71-80 ◽  
Author(s):  
Keun-Bong Yoo ◽  
Yinsheng He ◽  
Han-Sang Lee ◽  
Si-Yeon Bae ◽  
Doo-Soo Kim ◽  
...  
Keyword(s):  
High Temperatures ◽  
Steam Oxidation ◽  
Boiler Tube ◽  
Tube Steels
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