Novel pH-Sensitive Lipid-Polymer Composite Microspheres of 10-Hydroxycamptothecin Exhibiting Colon-Specific Biodistribution and Reduced Systemic Absorption

2013 ◽  
Vol 102 (6) ◽  
pp. 1752-1759 ◽  
Author(s):  
Li Gan ◽  
Yi-Ping Gao ◽  
Chun-Liu Zhu ◽  
Xin-Xin Zhang ◽  
Yong Gan
2013 ◽  
Vol 650 ◽  
pp. 226-230
Author(s):  
Xiu Qing Wang ◽  
Xiao Yun Liu ◽  
Liu Sheng Zha

The silver nanoparticles (Ag NPs) were loaded into pH sensitive polymer microspheres by in-situ reduction method, which are composed of linear poly(acrylic acid) (PAA) and cross-linked poly(N-isopropylacrylamide) (PNIPAM). The morphological structure of the formed composite microspheres and the particle diameter of the embeded Ag NPs were characterized by field emission transmission electron microscopy, their weight content by thermogravimetric analysis, and the pH sensitivity of the microspheres by dynamic light scattering. The absorbance spectra of the composite microspheres dispersed in the aqueous media with different pH values were measured by ultraviolet-visible spectrometry, and the obtained results show that the remarkable dependence relationship exists between the optical property of localized surface plasmon resonance (LSPR) of the loaded Ag NPs and the pH value, indicating that their LSPR property can be tuned by environmental pH value.


2015 ◽  
Vol 3 (17) ◽  
pp. 3604-3608 ◽  
Author(s):  
Atsuharu Inoue ◽  
Hitoshi Tamagawa ◽  
Yuya Oaki ◽  
Sadahito Aoshima ◽  
Hiroaki Imai

Dispersivity and molecular-trapping performance of mesostructured CaCO3–thermosensitive polymer composite microspheres were switched by a swing in temperature.


2008 ◽  
Vol 112 (11) ◽  
pp. 3315-3321 ◽  
Author(s):  
Hongbo Liu ◽  
Jia Guo ◽  
Lan Jin ◽  
Wuli Yang ◽  
Changchun Wang

2006 ◽  
Vol 300 (2) ◽  
pp. 564-568 ◽  
Author(s):  
Minjie Li ◽  
Hao Zhang ◽  
Junhu Zhang ◽  
Chunlei Wang ◽  
Kun Han ◽  
...  

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