Presystemic Metabolism of AZ’0908, A Novel mPGES-1 Inhibitor: An In Vitro and In Vivo Cross-Species Comparison

2013 ◽  
Vol 102 (3) ◽  
pp. 1106-1115 ◽  
Author(s):  
Johan Bylund ◽  
Tjerk Bueters
Keyword(s):  
Species Comparison ◽  
Presystemic Metabolism ◽  
Cross Species Comparison

Cross-species comparison of relative potencies and relative sensitivities of fishes to dibenzo-p-dioxins, dibenzofurans, and polychlorinated biphenyls in vitro

2015 ◽  
Vol 35 (1) ◽  
pp. 173-181 ◽  
Author(s):  
Bryanna K. Eisner ◽  
Jon A. Doering ◽  
Shawn C. Beitel ◽  
Steve Wiseman ◽  
Jason C. Raine ◽  
...  
Keyword(s):  
Polychlorinated Biphenyls ◽  
Species Comparison ◽  
Relative Potencies ◽  
Cross Species Comparison

scholarly journals Deciphering conserved identical sequences of mature miRNAs among six members of great apes

2018 ◽  
Vol 94 (2) ◽  
pp. 401-408
Author(s):  
Aftab Ali Shah ◽  
Mushtaq Ahmad ◽  
Taqweem Ul-Haq
Keyword(s):  
Gene Families ◽  
Mature Mirnas ◽  
Neighbor Joining ◽  
Species Comparison ◽  
Rna Molecules ◽  
Sequence Identity ◽  
Species Specific ◽  
Post Transcriptional Regulation ◽  
Cross Species Comparison

MicroRNAs (miRNAs) are a group of small RNA molecules which act as negative regulators of gene expression by controlling post-transcriptional regulation through binding to their corresponding mRNAs. Due to their small size, their nucleotide compositions are expected to be similar, but until now, the extent of similarity has not been reported in humans and their six phylogenetically closely related members of hominids. The present study allows direct comparison among six members of hominid species (Homosapiens, Gorillagorilla, Panpaniscus, Pongopygmaeus, Pantroglodytes and Symphalangussyndactylus) in terms of their miRNA repertoire, their evolutionary distance to human, as well as, the categorization of identical species-specific miRNAs. For this purpose, a total of 2694, 370, 157, 673, 590 and 10 mature miRNA sequences of Homosapiens, Gorillagorilla, Panpaniscus, Pongopygmaeus, Pantroglodytes and Symphalangussyndactylus respectively were retrieved from miRbase 22. A total of 12, 4, 4 and 3 conserved clusters with identical miRNA sequences that belong to the same gene families were found in Homosapiens, Gorillagorilla, Pongopygmaeus, Pantroglodytes respectively by neighbor-joining method using MEGA7 software. Interestingly, cross-species comparison has also shown a set of conserved identical miRNA sequences. Homologs of human mature miRNAs with 100% sequence identity are expected to have similar functions in the studied primates. Further in-vitro study is required to investigate common targets for identical miRNAs in the studied primates.

Metabolites identification and species comparison of Oroxylin A, an anti-cancer Flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS

Xenobiotica ◽  
2022 ◽  
pp. 1-25
Author(s):  
Yueying Bian ◽  
Mengqi Sun ◽  
Huili Chen ◽  
Guanghui Ren ◽  
Kejia Fu ◽  
...  
Keyword(s):  
Species Comparison ◽  
Oroxylin A ◽  
Anti Cancer ◽  
Tof Ms

scholarly journals Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0221230 ◽  
Author(s):  
Kyla M. Walter ◽  
Katharina Dach ◽  
Keri Hayakawa ◽  
Susanne Giersiefer ◽  
Heike Heuer ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Signaling ◽  
Species Comparison

Cross-species comparison of in vivo PK/PD relationships for second-generation antisense oligonucleotides targeting apolipoprotein B-100

2009 ◽  
Vol 77 (5) ◽  
pp. 910-919 ◽  
Author(s):  
Rosie Z. Yu ◽  
Kristina M. Lemonidis ◽  
Mark J. Graham ◽  
John E. Matson ◽  
Rosanne M. Crooke ◽  
...  
Keyword(s):  
Apolipoprotein B ◽  
Antisense Oligonucleotides ◽  
Second Generation ◽  
Species Comparison ◽  
Cross Species Comparison
Sign in / Sign up

Export Citation Format

Share Document