Novel Quality by Design Tools for Concentrated Drug Suspensions: Surface Energy Profiling and the Fractal Concept of Flocculation

2013 ◽  
Vol 102 (3) ◽  
pp. 994-1007 ◽  
Author(s):  
Jan Kendall De Kruif ◽  
Jiyi Khoo ◽  
Roberto Bravo ◽  
Martin Kuentz
Keyword(s):  
Surface Energy ◽  
Quality By Design ◽  
Design Tools ◽  
Energy Profiling

Quality by Design tools reducing the gap from bench to bedside for nanomedicine

2021 ◽  
Author(s):  
Angela Bonaccorso ◽  
Giulia Russo ◽  
Francesco Pappalardo ◽  
Claudia Carbone ◽  
Giovanni Puglisi ◽  
...  
Keyword(s):  
Quality By Design ◽  
Design Tools

The annealed (0001) α-alumina surface and its influence on thin-film growth

1995 ◽  
Vol 53 ◽  
pp. 336-337
Author(s):  
Michael W. Bench ◽  
Paul G. Kotula ◽  
C. Barry Carter
Keyword(s):  
Electron Microscopy ◽  
Surface Energy ◽  
Film Growth ◽  
Thin Film Growth ◽  
Energy Calculations ◽  
Transmission Electron ◽  
Reflection Electron Microscopy ◽  
Low Energy Electron ◽  
Surface Nature

The growth of semiconductors, superconductors, metals, and other insulators has been investigated using alumina substrates in a variety of orientations. The surface state of the alumina (for example surface reconstruction and step nature) can be expected to affect the growth nature and quality of the epilayers. As such, the surface nature has been studied using a number of techniques including low energy electron diffraction (LEED), reflection electron microscopy (REM), transmission electron microscopy (TEM), molecular dynamics computer simulations, and also by theoretical surface energy calculations. In the (0001) orientation, the bulk alumina lattice can be thought of as a layered structure with A1-A1-O stacking. This gives three possible terminations of the bulk alumina lattice, with theoretical surface energy calculations suggesting that termination should occur between the Al layers. Thus, the lattice often has been described as being made up of layers of (Al-O-Al) unit stacking sequences. There is a 180° rotation in the surface symmetry of successive layers and a total of six layers are required to form the alumina unit cell.

The nucleation of cavities at grain boundaries

1987 ◽  
Vol 45 ◽  
pp. 288-291
Author(s):  
P. J. Goodhew
Keyword(s):  
Surface Tension ◽  
Surface Energy ◽  
Grain Boundaries ◽  
Radiation Damage ◽  
Impurity Concentration ◽  
Driving Force ◽  
Nucleation And Growth ◽  
Phase Boundaries ◽  
Cavity Nucleation ◽  
Spherical Bubble

Cavity nucleation and growth at grain and phase boundaries is of concern because it can lead to failure during creep and can lead to embrittlement as a result of radiation damage. Two major types of cavity are usually distinguished: The term bubble is applied to a cavity which contains gas at a pressure which is at least sufficient to support the surface tension (2g/r for a spherical bubble of radius r and surface energy g). The term void is generally applied to any cavity which contains less gas than this, but is not necessarily empty of gas. A void would therefore tend to shrink in the absence of any imposed driving force for growth, whereas a bubble would be stable or would tend to grow. It is widely considered that cavity nucleation always requires the presence of one or more gas atoms. However since it is extremely difficult to prepare experimental materials with a gas impurity concentration lower than their eventual cavity concentration there is little to be gained by debating this point.

Soldier-Centered Design Tools: Recent Developments, Challenges, and Paths Forward

2005 ◽  
Author(s):  
John K. Hawley ◽  
John F. Lockett ◽  
Laurel E. Allender
Keyword(s):  
Design Tools ◽  
Recent Developments

The creation of quality by design

1962 ◽  
Vol 41 (10) ◽  
pp. 609
Author(s):  
B.H. Dyson
Keyword(s):  
Quality By Design ◽  
The Creation

Influence of Fiber Surface Energy on Mechanical Properties of Sisal Fiber - Bio Based Epoxy Composites

2019 ◽  
Vol 35 (4) ◽  
pp. 485-496
Author(s):  
S. RAJKUMAR ◽  
◽  
R. JOSEPH BENSINGH ◽  
M. ABDUL KADER ◽  
SANJAY K NAYAK ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Surface Energy ◽  
Fiber Surface ◽  
Epoxy Composites ◽  
Sisal Fiber

Perancangan Pengkondisian Udara pada Ruangan Steril Rumah Sakit Mitra Medika dengan Standard Cleanroom Menggunakan Instalasi Ducting

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Fremmy Raymond Agustinus
Keyword(s):  
Air Conditioning ◽  
Static Pressure ◽  
Filter Medium ◽  
Positive Pressure ◽  
Design Tools ◽  
Microsoft Excel ◽  
Cooling Unit ◽  
X 24 ◽  
Air Passage ◽  
Booster Fan

Desain penyejuk udara juga dapat diterapkan di bidang kesehatan, dengan standar Cleanroom dapat diperoleh suhu, kelembaban, kenyamanan dan kebersihan yang dibutuhkan untuk ruang steril (ruang bedah). Perancangan pendingin udara dalam hal ini dilakukan dengan menentukan beban pendinginan yang diperlukan untuk ruang steril (ruang bedah), kemudian menentukan ukuran ducting, jalur ducting, dan jumlah penggunaan ducting. Desain ini menggabungkan unit split saluran yang dimodifikasi, kipas booster, filter pra, filter medium, dan filter HEPA dengan menggunakan saluran aluminium preinsulated sebagai saluran udara. Desain dilakukan dengan menggunakan perangkat lunak AutoCAD 2012, Design Tools Duct Sizer, dan Microsoft Excel. Dari hasil perhitungan dan desain didapatkan kebutuhan kapasitas 3 ruang bedah yaitu ducted ducted 100.000 BTUH sebanyak 3 unit, booster fan 3.3 - 4 Di WG sebanyak 3 unit, pre filter 24 "x 24" x 2 "6 set, filter menengah 610 x 610 x 290 mm 6 set, dan filter HEPA 1220 x 610 x 70 mm 12. Untuk ruang steril, tekanan statis yang dihasilkan oleh unit pendingin harus lebih besar daripada tekanan statis yang dihasilkan dari unit yang ada. di ruang semi steril. Dengan kata lain, ruang steril harus memiliki tekanan positif terhadap ruang semi steril. Hal ini dimaksudkan agar udara di ruang semi steril tidak masuk ke ruang steril ketika pintu antar ruangan dibuka. Desain dan perhitungan ruang bedah, suhu nyata yang diperoleh adalah 23 ° C ± 2 ° C dan kelembaban relatif yang diperoleh adalah 60% ± 2%.   Air conditioning design can also be applied in the health field, with cleanroom standard can be obtained temperature, humidity, comfort and hygiene needed for sterile room (surgical room). The design of air conditioning in this case is done by determining the cooling load required for the sterile room (surgical room), then determining the ducting size, ducting path, and the amount of ducting usage. This design combines modified ducted split unit, booster fan, pre filter, medium filter, and HEPA filter by using preinsulated aluminum duct as an air passage. The design is done by using AutoCAD 2012 software, Design Tools Duct Sizer, and Microsoft Excel. From the calculation and design result obtained the capacity requirement of 3 surgical room that is split ducted 100.000 BTUH as many as 3 units, booster fan 3.3 - 4 In WG as many as 3 units, pre filter 24"x 24" x 2" 6 sets, medium filter 610 x 610 x 290 mm 6 sets, and HEPA filter 1220 x 610 x 70 mm 12 sets. For the sterile room, the static pressure generated by the cooling unit shall be larger than the static pressure generated from the unit present in the semi sterile room. In other words, the sterile room must have positive pressure to the semi sterile room. It is intended that the air in the semi sterile room does not enter into the sterile room when the door between room opened. In this surgical room design and calculation, real temperature obtained is 23 °C ± 2 °C and the relative moisture obtained is 60% ± 2%.

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