Selective Domain Stabilization as a Strategy to Reduce Fusion Protein Aggregation

2012 ◽  
Vol 101 (4) ◽  
pp. 1400-1409 ◽  
Author(s):  
Amanda A. Cordes ◽  
Christopher W. Platt ◽  
John F. Carpenter ◽  
Theodore W. Randolph
Keyword(s):  
Fusion Protein ◽  
Protein Aggregation ◽  
Domain Stabilization

scholarly journals Influence of silk–silica fusion protein design on silica condensation in vitro and cellular calcification

RSC Advances ◽  
2016 ◽  
Vol 6 (26) ◽  
pp. 21776-21788 ◽  
Author(s):  
Robyn Plowright ◽  
Nina Dinjaski ◽  
Shun Zhou ◽  
David J. Belton ◽  
David L. Kaplan ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Protein Aggregation ◽  
Protein Design ◽  
C Terminus ◽  
Entropically Driven

Peptide location in silk–R5 genetic chimeras (N vs. C terminus) moderates cellular calcification and influences silicification through entropically driven protein aggregation.

An Ultra-Structural Study of Human Melanoma in Vivo and Vitro

1976 ◽  
Vol 34 ◽  
pp. 258-259
Author(s):  
James R. Gaylor ◽  
Fredda Schafer ◽  
Robert E. Nordquist
Keyword(s):  
Endoplasmic Reticulum ◽  
Golgi Apparatus ◽  
Protein Aggregation ◽  
Structural Study ◽  
Human Melanoma ◽  
Protein Matrix ◽  
Early Form ◽  
Endoplasmic Reticulum Protein ◽  
Mitochondrial Origin

Several theories on the origin of the melanosome exist. These include the Golgi origin theory, in which a tyrosinase-rich protein is "packaged" by the Golgi apparatus, thus forming the early form of the melanosome. A second theory postulates a mitochondrial origin of melanosomes. Its author contends that the melanosome is a modified mitochondria which acquires melanin during its development. A third theory states that a pre-melanosome is formed in the smooth or rough endoplasmic reticulum. Protein aggregation is suggested by one author as a possible source of the melanosome. This fourth theory postulates that the melanosome originates when the protein products of several genetic loci aggregate in the cytoplasm of the melanocyte. It is this protein matrix on which the melanin is deposited. It was with these theories in mind that this project was undertaken.

A novel P159L mutation in the Parkin gene related to autosomal dominantly inherited late onset parkinsonism and protein aggregation

2004 ◽  
Vol 31 (S 1) ◽  
Author(s):  
R Krüger ◽  
FP Marx ◽  
D Berg ◽  
C Holzmann ◽  
T Müller ◽  
...  
Keyword(s):  
Protein Aggregation ◽  
Late Onset ◽  
Parkin Gene
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