Effect of Agitation Regimen on the in vitro Release of Leuprolide from Poly(Lactic-Co-Glycolic) Acid Microparticles

2012 ◽  
Vol 101 (3) ◽  
pp. 1212-1220 ◽  
Author(s):  
Aurélie Schoubben ◽  
Paolo Blasi ◽  
Patrick P. Deluca
Keyword(s):  
Glycolic Acid ◽  
In Vitro Release ◽  
Vitro Release

Flow-through cell-based in vitro release method for triamcinolone acetonide poly (lactic-co-glycolic) acid microspheres

2020 ◽  
Vol 579 ◽  
pp. 119130 ◽  
Author(s):  
Namita P. Tipnis ◽  
Jie Shen ◽  
Derek Jackson ◽  
Daniel Leblanc ◽  
Diane J. Burgess
Keyword(s):  
Triamcinolone Acetonide ◽  
Glycolic Acid ◽  
In Vitro Release ◽  
Flow Through ◽  
Release Method ◽  
Vitro Release

In Vitro Release and Degradation Study of Letrozole-Loaded Poly(Lactic-co-Glycolic Acid) Microparticles

JOM ◽  
2020 ◽  
Vol 73 (1) ◽  
pp. 450-459
Author(s):  
Akhtar Jahan Siddiqa ◽  
Nilesh Kumar Shrivastava ◽  
M. E. Ali Mohsin ◽  
Mustufa Haider Abidi ◽  
Mohamed Abdel Fattah Sharaf ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
In Vitro Release ◽  
Degradation Study ◽  
Vitro Release

scholarly journals Elaboration of Charged Poly(Lactic-co-Glycolic Acid) Microparticles for Effective Release of Tranexamic Acid

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 808
Author(s):  
Ming-Hsi Huang ◽  
Shun-Ying Huang ◽  
Yi-Xuan Chen ◽  
Cheng-You Chen ◽  
Yung-Sheng Lin
Keyword(s):  
Tranexamic Acid ◽  
Glycolic Acid ◽  
Model Compound ◽  
In Vitro Release ◽  
Double Emulsion ◽  
Scanning Calorimetry ◽  
Solvent Evaporation Process ◽  
Vitro Release ◽  
Thermal Stability Of

In this study, tranexamic acid (TA) was used as a model compound to study the charge effect on the physicochemical properties of poly(lactic-co-glycolic acid) (PLGA) microparticles (MPs). Charged PLGA MPs were elaborated by the incorporation of a quaternary ammonium, cetyltrimethylammonium bromide (CTAB), during the double emulsion solvent evaporation process. Three TA-CTAB-carrying modes of PLGA MPs were designed in the CTAB-free (TA-MP), adsorption (TA-CTABAD), or encapsulation (TA-CTABEN) form. The obtained MPs were characterized by morphology and TA-MP affinity. The experiment revealed that the three prepared MPs were spherical and smooth, with pores on their surfaces. TA-CTABAD had a relatively narrow size distribution, compared with that of TA-MP and TA-CTABEN. The particle sizes of TA-MP, TA-CTABEN, TA-CTABAD were measured as 59 ± 17, 54 ± 20, and 19 ± 8 μm, respectively. The zeta potential of the three MPs was found to be in the order: TA-CTABAD > TA-CTABEN > TA-MP. Differential scanning calorimetry (DSC) indicated that the manufacturing process had no influence on the glass transition temperature of the MPs, which was close to 48 °C. Thermogravimetric analysis illustrated that the presence of CTAB slightly changed the thermal stability of PLGA MPs. In vitro release showed that TA-CTABAD exhibited faster TA release than TA-MP and TA-CTABEN in a basic environment (pH of 13), probably because of electrostatic attraction. At pH = 1, the release of TA from TA-CTABEN was faster than those from TA-MP and TA-CTABAD, probably because of electrostatic repulsion. However, the effect of electrostatic interaction was not significant at pH = 7.4.

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