scholarly journals Effect of Ion Pairing on In Vitro Transcorneal Permeability of a Δ9-Tetrahydrocannabinol Prodrug: Potential in Glaucoma Therapy

2012 ◽  
Vol 101 (2) ◽  
pp. 616-626 ◽  
Author(s):  
Tushar Hingorani ◽  
Waseem Gul ◽  
Mahmoud Elsohly ◽  
Michael A. Repka ◽  
Soumyajit Majumdar
Keyword(s):  
Ion Pairing ◽  
Glaucoma Therapy ◽  
Transcorneal Permeability

Effect of Ion Pairing with Alkylamines on the In-vitro Dermal Penetration and Local Tissue Disposition of Salicylates

2000 ◽  
Vol 52 (8) ◽  
pp. 929-940 ◽  
Author(s):  
STELLA A. MEGWA ◽  
SHEREE E. CROSS ◽  
MICHAEL W. WHITEHOUSE ◽  
HEATHER A. E. BENSON ◽  
MICHAEL S. ROBERTS
Keyword(s):  
Ion Pairing ◽  
Local Tissue ◽  
Dermal Penetration ◽  
Tissue Disposition

Enhanced in vitro antitumor efficacy of a polyunsaturated fatty acid-conjugated pH-responsive self-assembled ion-pairing liposome-encapsulated prodrug

2020 ◽  
Vol 31 (15) ◽  
pp. 155101
Author(s):  
Yuxian Wang ◽  
Panpan Fan ◽  
Liying Zhu ◽  
Wei Zhuang ◽  
Ling Jiang ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Ion Pairing ◽  
Antitumor Efficacy ◽  
Ph Responsive ◽  
Self Assembled

scholarly journals Facilitated Buccal Insulin Delivery via Hydrophobic Ion-Pairing Approach: In vitro and ex vivo Evaluation

2021 ◽  
Vol Volume 16 ◽  
pp. 4677-4691
Author(s):  
Santosh Bashyal ◽  
Jo-Eun Seo ◽  
Taekwang Keum ◽  
Gyubin Noh ◽  
Shrawani Lamichhane ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Ion Pairing ◽  
Insulin Delivery ◽  
Hydrophobic Ion Pairing

scholarly journals Distribution of Gold Nanoparticles in the Anterior Chamber of the Eye after Intracameral Injection for Glaucoma Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 901
Author(s):  
Tobias Sonntag ◽  
Franziska Froemel ◽  
W. Daniel Stamer ◽  
Andreas Ohlmann ◽  
Rudolf Fuchshofer ◽  
...  
Keyword(s):  
Anterior Chamber ◽  
Trabecular Meshwork ◽  
Colloidal Stability ◽  
Ex Vivo ◽  
Optimal Size ◽  
Gold Content ◽  
Particle Volume ◽  
Glaucoma Therapy ◽  
Intracameral Injection

In glaucoma therapy, nanoparticles (NPs) are a favorable tool for delivering drugs to the outflow tissues of the anterior chamber of the eye where disease development and progression take place. In this context, a prerequisite is an efficient enrichment of NPs in the trabecular meshwork with minimal accumulation in off-target tissues such as the cornea, lens, iris and ciliary body. We evaluated the optimal size for targeting the trabecular meshwork by using gold NPs of 5, 60, 80 and 120 nm with a bare surface (AuNPs) or coated with hyaluronic acid (HA-AuNPs). NPs were compared regarding their colloidal stability, distribution in the anterior chamber of the eye ex vivo and cellular uptake in vitro. HA-AuNPs demonstrated an exceptional colloidal stability. Even after application into porcine eyes ex vivo, the HA coating prevented an aggregation of NPs inside the trabecular meshwork. NPs with a diameter of 120 nm exhibited the highest volume-based accumulation in the trabecular meshwork. Off-target tissues in the anterior chamber demonstrated an exceptionally low gold content. Our findings are particularly important for NPs with encapsulated anti-glaucoma drugs because a higher particle volume would be accompanied by a higher drug payload.

OFLOXACIN ION PAIRING WITHIN SUBMICRON EMULSION: A POTENTIAL APPROACH FOR OCULAR DELIVERY

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (04) ◽  
pp. 37-44
Author(s):  
D Pandey ◽  
R Singh ◽  
S Jain ◽  
D Jain ◽  
Keyword(s):  
Antimicrobial Activity ◽  
Partition Coefficient ◽  
Ion Pairing ◽  
Sodium Deoxycholate ◽  
Free Drug ◽  
Ocular Delivery ◽  
Potential Approach ◽  
Ocular Infections ◽  
Submicron Emulsion

The aim of the work was to improve the entrapment of ofloxacin within the submicron emulsion by ion pairing with sodium deoxycholate to improve antimicrobial activity and precorneal retention. Partition coefficient of ofloxacin-sodium deoxycholate was found to be 3.788, compared to 0.113 for the drug alone. Formulation was characterized for globules size 0.143 ± 0.07 μm, viscosity 3.8 ± 0.2 cP and pH, 7.1 ± 0.3. The entrapment was 80 ± 1% for ofloxacin-sodium deoxycholate in submicron emulsion compared to 57 ± 2% for the drug alone. More than 90% drug remained after 90 days in optimized formulations and was found stable. SEM confirmed droplets size to be 200 nm and spherical. Drug released 53.16% after 24 h from optimized formulation. In vitro antimicrobial efficacy improved against S. aureus as compared to free drug. No toxicity of optimized formulation on HET-CAM test was observed. Designed formulation may hold some promise for severe ocular infections where frequent dosing is required.

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