A Convenient Method to Measure Blood–Plasma Concentration Ratio Using Routine Plasma Collection in In Vivo Pharmacokinetic Studies

2011 ◽  
Vol 100 (12) ◽  
pp. 5293-5298 ◽  
Author(s):  
Leonid M. Berezhkovskiy ◽  
Xiaolin Zhang ◽  
Jonathan Cheong
Keyword(s):  
Plasma Concentration ◽  
Blood Plasma ◽  
Convenient Method ◽  
Concentration Ratio ◽  
Pharmacokinetic Studies ◽  
Plasma Concentration Ratio ◽  
Plasma Collection

Variability of the blood/plasma concentration ratio of pethidine

1986 ◽  
Vol 38 (7) ◽  
pp. 557-558 ◽  
Author(s):  
Denis J. Morgan ◽  
William J. Thiel ◽  
Carmen Rosa ◽  
Laurence E. Mather
Keyword(s):  
Plasma Concentration ◽  
Blood Plasma ◽  
Concentration Ratio ◽  
Plasma Concentration Ratio

Prediction of Milk/Plasma Concentration Ratio of Drugs

2003 ◽  
Vol 37 (9) ◽  
pp. 1299-1306 ◽  
Author(s):  
Line Alleslev Larsen ◽  
Shinya Ito ◽  
Gideon Koren
Keyword(s):  
Plasma Concentration ◽  
Concentration Ratio ◽  
Plasma Concentration Ratio

Salivary estriol concentrations during normal pregnancies, and a comparison with plasma estriol.

1984 ◽  
Vol 30 (1) ◽  
pp. 120-121 ◽  
Author(s):  
J J Evans ◽  
A R Wilkinson ◽  
D R Aickin
Keyword(s):  
Plasma Concentration ◽  
Concentration Ratio ◽  
Reference Interval ◽  
Individual Factor ◽  
Non Invasive ◽  
Specimen Collection ◽  
Plasma Concentration Ratio ◽  
Highly Correlated ◽  
Unconjugated Estriol ◽  
Stimulation Of

Abstract Saliva would have advantages over plasma or urine for monitoring estriol during pregnancy. Specimen collection, after stimulation of flow by citric acid, is non-invasive and simple. We measured concentrations of unconjugated estriol in saliva and compared them with those in plasma in normal pregnancies, and found a good correlation (r = 0.79). In addition, trends of concentrations in saliva and plasma were statistically compared and found to be highly correlated. The variation among individuals in the saliva/plasma concentration ratio suggested that some inter-individual factor(s) may affect this relationship. The normal reference interval for unconjugated estriol concentration in saliva from 20 weeks of gestation to term was established.

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