Freeze drying of nanosuspensions, 2: the role of the critical formulation temperature on stability of drug nanosuspensions and its practical implication on process design

2011 ◽  
Vol 100 (10) ◽  
pp. 4471-4481 ◽  
Author(s):  
Jakob Beirowski ◽  
Sabine Inghelbrecht ◽  
Albertina Arien ◽  
Henning Gieseler
Keyword(s):  
Process Design ◽  
Freeze Drying ◽  
Practical Implication

Choked flow and importance of Mach I in freeze-drying process design

2010 ◽  
Vol 65 (21) ◽  
pp. 5716-5727 ◽  
Author(s):  
Sajal M. Patel ◽  
Swetaprovo Chaudhuri ◽  
Michael J. Pikal
Keyword(s):  
Process Design ◽  
Freeze Drying ◽  
Drying Process ◽  
Choked Flow

Neformalni obrazovni kontekst i nastava prirode i društva u izmenjenom društvenom kontekstu – metodički pristup i značaj

2021 ◽  
Author(s):  
Milana Pivaš
Keyword(s):  
Social Context ◽  
Teaching Practice ◽  
Practical Implication ◽  
Integrative Approach ◽  
Future Research ◽  
Social Phenomena ◽  
The Subject ◽  
Traditional Paradigm ◽  
Informal Context

Equally effective and demanding for all students, the traditional paradigm prevents independent acquisition of knowledge in a changed social context. Students should be able to independently research and analyze natural and social phenomena and processes. The role of the teacher is to create a complete picture, and not to interpret the content knowledge as biological, geographical, or historical. To avoid the passivity of students in the teaching process, it is necessary to choose an informal context and adapt it to the content being learned. In this paper, we have tried to point out the importance of an integrative approach in the non-formal educational context within the content of the subject Science and Social studies. We have presented the practical implication regarding natural and social contents. Lack of resources, time and interest of teachers are cited as obstacles to this way of working. In addition to pointing out the effective application of the informal context in a changed social context, we also provided suggestions for future research to improve teaching practice.

scholarly journals Efficient utilization of renewable feedstocks: the role of catalysis and process design

2017 ◽  
Vol 376 (2110) ◽  
pp. 20170064 ◽  
Author(s):  
Regina Palkovits ◽  
Irina Delidovich
Keyword(s):  
Elevated Temperature ◽  
Gas Phase ◽  
Process Design ◽  
Circular Economy ◽  
Paradigm Shift ◽  
Efficient Utilization ◽  
Polar Solvents ◽  
Platform Chemicals ◽  
Renewable Feedstocks

Renewable carbon feedstocks such as biomass and CO 2 present an important element of future circular economy. Especially biomass as highly functionalized feedstock provides manifold opportunities for the transformation into attractive platform chemicals. However, this change of the resources requires a paradigm shift in refinery design. Fossil feedstocks are processed in gas phase at elevated temperature. In contrast, biorefineries are based on processes in polar solvents at moderate conditions to selectively deoxygenate the polar, often thermally instable and high-boiling molecules. Here, challenges of catalytic deoxygenation, novel strategies for separation and opportunities provided at the interface to biotechnology are discussed in form of showcases. This article is part of a discussion meeting issue ‘Providing sustainable catalytic solutions for a rapidly changing world’.

scholarly journals Role of embB in natural and acquired resistance to ethambutol in mycobacteria.

1997 ◽  
Vol 41 (10) ◽  
pp. 2270-2273 ◽  
Author(s):  
F Alcaide ◽  
G E Pfyffer ◽  
A Telenti
Keyword(s):  
Nontuberculous Mycobacteria ◽  
Practical Implication ◽  
Acquired Resistance ◽  
Fold Increase ◽  
Drug Susceptibility ◽  
Natural Resistance ◽  
Intrinsic Resistance ◽  
Resistant Strains ◽  
High Level

The mycobacterial embCAB operon encodes arabinosyl transferases, putative targets of the antimycobacterial agent ethambutol (EMB). Mutations in embB lead to resistance to EMB in Mycobacterium tuberculosis. The basis for natural, intrinsic resistance to EMB in nontuberculous mycobacteria (NTM) is not known; neither is the practical implication of resistance to EMB in the absence of embB mutations in M. tuberculosis well understood. The conserved embB resistance-determining region (ERDR) of a collection of 13 strains of NTM and 12 EMB-resistant strains of M. tuberculosis was investigated. Genotypes were correlated with drug susceptibility phenotypes. High-level natural resistance to EMB (MIC, . or =64 microg/ml) was associated with a variant amino acid motif in the ERDR of M. abscessus, M. chelonae, and M. leprae. Transfer of the M. abscessus emb allele to M. smegmatis resulted in a 500-fold increase in the MICs. In M. tuberculosis, embB mutations were associated with MICs of > or =20 microg/ml while resistance not associated with an ERDR mutation generally resulted in MICs of < or =10 microg/ml. These data further support the notion that the emb region determines intrinsic and acquired resistance to EMB and might help in the reassessment of the current recommendations for the screening and treatment of infections with EMB-resistant M. tuberculosis and NTM.

scholarly journals DOES EMPLOYER BRANDING AFFECT JOB EMBEDDEDNESS? THE MEDIATING ROLE OF DEDICATION AND PERCEIVED ORGANIZATIONAL SUPPORT

2018 ◽  
Vol 6 (3) ◽  
Author(s):  
Berivan TATAR ◽  
Büşra MÜCELDİLİ ◽  
Oya ERDİL
Keyword(s):  
Organizational Support ◽  
Structural Equation ◽  
Perceived Organizational Support ◽  
Practical Implication ◽  
Job Embeddedness ◽  
Equation Modeling ◽  
Future Research ◽  
Employer Branding ◽  
Mediating Role

Along with emerging the war for talent, scholars have given ample attention to employer branding concept referring the a whole of values and benefits that organizations provide for both attracting and retaining the best possible talent. In this context, the purpose of this study is to investigate the effect of employer branding on the favorable employee behavior as job embeddedness via the mediating role of the dedication and perceived organizational support.  Data collected from 200 respondents have been analyzed through Structural Equation Modeling. As a result of analyses, the hypothesized model was supported. Findings of the study revealed that employer branding has effect the dedication, job embeddedness and organizational support perception of employees. Additionally, dedication and perceived organizational support partially mediate the relationship between employer branding and job embeddedness. Finally, the theoretical and practical implication, limitations of the study and suggestions for future research are discussed.

scholarly journals The Effect of Independence and Integrity on Audit Quality: Is There A Moderating Role for E-Audit?

2021 ◽  
Vol 23 (3) ◽  
Author(s):  
Diza Dianeke Budi Prabowo ◽  
Dwi Suhartini
Keyword(s):  
Industrial Revolution ◽  
Audit Quality ◽  
Practical Implication ◽  
Financial Statements ◽  
Auditor Independence ◽  
Audit Process ◽  
Accounting Firms ◽  
Audit Reports ◽  
The Impact

The financial statements must be reliable and become a benchmark in considering an audit decision on the financial statements. In order for this to be achieved, independence and integrity is required in carrying out the audit process. E-Audit helps overcome challenges in the industrial revolution 4.0 and prevent fraud. This research aims of testing and analyzing the role of e-audit in moderating the impact of auditor independence and integrity on audit quality. The data was collected through a questionnaire distributed to auditors at Public Accounting Firms in Surabaya. There are 36 respondents involved. The data were analyzed using SmartPLS. The results showed that auditor independence positively effect audit quality, auditor integrity positively effect audit quality; e-audit does non moderate the effect of auditor independence on audit quality; ande-Audit negatively moderates the effect of auditor integrity on audit quality. The practical implication of this research is that when determining high audit quality, independent auditors should at least increase their independence and integrity so that the resulting audit reports are of high quality and can be a reference for decision makers.

scholarly journals Glutathione Protects Lactobacillus sanfranciscensis against Freeze-Thawing, Freeze-Drying, and Cold Treatment

2010 ◽  
Vol 76 (9) ◽  
pp. 2989-2996 ◽  
Author(s):  
Juan Zhang ◽  
Guo-Cheng Du ◽  
Yanping Zhang ◽  
Xian-Yan Liao ◽  
Miao Wang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Stress Responses ◽  
Freeze Drying ◽  
Unsaturated Fatty Acids ◽  
Cold Treatment ◽  
Protective Role ◽  
Intracellular Accumulation ◽  
Lactobacillus Sanfranciscensis

ABSTRACT Lactobacillus sanfranciscensis DSM20451 cells containing glutathione (GSH) displayed significantly higher resistance against cold stress induced by freeze-drying, freeze-thawing, and 4°C cold treatment than those without GSH. Cells containing GSH were capable of maintaining their membrane structure intact when exposed to freeze-thawing. In addition, cells containing GSH showed a higher proportion of unsaturated fatty acids in cell membranes upon long-term cold treatment. Subsequent studies revealed that the protective role of GSH against cryodamage of the cell membrane is partly due to preventing peroxidation of membrane fatty acids and protecting Na+,K+-ATPase. Intracellular accumulation of GSH enhanced the survival and the biotechnological performance of L. sanfranciscensis, suggesting that the robustness of starters for sourdough fermentation can be improved by selecting GSH-accumulating strains. Moreover, the results of this study may represent a further example of mechanisms for stress responses in lactic acid bacteria.

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