scholarly journals A Randomized, Quadruple Crossover Single-Blind Study on Immediate Action of Chewed and Unchewed Low-Dose Acetylsalicylic Acid Tablets in Healthy Volunteers

2011 ◽  
Vol 100 (9) ◽  
pp. 3884-3891 ◽  
Author(s):  
Yoshimichi Sai ◽  
Akiyo Kusaka ◽  
Kaori Imanishi ◽  
Manami Matsumoto ◽  
Rie Takahashi ◽  
...  
Keyword(s):  
Acetylsalicylic Acid ◽  
Healthy Volunteers ◽  
Low Dose ◽  
Blind Study ◽  
Single Blind

scholarly journals A comparison of low-dose risperidone to paroxetine in the treatment of panic attacks: a randomized, single-blind study

2009 ◽  
Vol 9 (1) ◽  
Author(s):  
James M Prosser ◽  
Samantha Yard ◽  
Annie Steele ◽  
Lisa J Cohen ◽  
Igor I Galynker
Keyword(s):  
Low Dose ◽  
Panic Attacks ◽  
Blind Study ◽  
Single Blind

Influence of Vitamin E on Plasma Malondialdehyde- Like Material in Man

1984 ◽  
Vol 51 (03) ◽  
pp. 347-348 ◽  
Author(s):  
C Cordova ◽  
A Musca ◽  
F Violi ◽  
C Alessandri ◽  
A Ghiselli ◽  
...  
Keyword(s):  
Vitamin E ◽  
Healthy Subjects ◽  
Placebo Treatment ◽  
Blind Study ◽  
Single Blind ◽  
Plasma Malondialdehyde

SummaryThe behaviour of plasma malondialdehyde-like material (MDA-LM) was evaluated in 13 healthy subjects by a single-blind study that consisted of placebo (30 days), vitamin E treatment (300 mg/day) (30 days) and placebo (30 days). The study demonstrated that MDA-LM did not change during placebo treatment while it significantly decreased after vitamin E administration.

scholarly journals Validation of an HPLC Assay Method for Routine QC Testing and Stability Study of Compounded Low-Dose Capsules of Acetylsalicylic Acid

2018 ◽  
Vol 3 (4) ◽  
pp. 199-206
Author(s):  
Nelly Lonca ◽  
Fabienne Maillard ◽  
Géraldine Leguelinel ◽  
Tahmer Sharkawi ◽  
Ian Soulairol
Keyword(s):  
Acetylsalicylic Acid ◽  
Orthophosphoric Acid ◽  
Low Dose ◽  
Stability Study ◽  
Assay Method ◽  
Stability Studies ◽  
Physicochemical Stability ◽  
Hospital Pharmacies ◽  
Provocation Testing ◽  
Low Dosage

Abstract Background The intolerance to Acetylsalicylic Acid (ASA) can be detected by conducting oral provocation testing (OPT), which is to gradually introduce low doses of ASA. To perform this test, hospital pharmacies compound small batches of different low-dosage ASA capsules. This work aims to validate a method for fast HPLC-UV assay that allows routine quality control and physicochemical stability studies of capsules. Methods The chromatographic separation is performed using a C18 column Kinetex (100 A, 50×4.6 mm, 2.6 µm) equipped with a precolumn C18. Separation is achieved using a mobile phase composed of water-acetonitrile-orthophosphoric acid (68:32:0.2 v/v/v) at a flow rate of 0.8 mL/min and UV detection at 237 nm. Results Validation shows that the method was suitable for routine analysis and could be used to perform stability studies. Conclusions The 5, 25, 100 and 250 mg dosed capsules show acceptable stability over 12 months, while the 1 mg dosed capsule show an unacceptable degradation of more than 15 % after 3 months. Therefore, hospital pharmacy can plan the manufacture of capsules and anticipate the requests of doctors.

Su1782 Effect of Proton Pump Inhibitors on the Discontinuation of Low-Dose Acetylsalicylic Acid in UK Primary Care

2012 ◽  
Vol 142 (5) ◽  
pp. S-502
Author(s):  
Elisa Martén-Merino ◽  
Saga Johansson ◽  
Luis A. Garcia Rodriguez
Keyword(s):  
Primary Care ◽  
Acetylsalicylic Acid ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Low Dose
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