Oral Delivery System for Two-pulse Colonic Release of Protein Drugs and Protease Inhibitor/Absorption Enhancer Compounds

2011 ◽  
Vol 100 (8) ◽  
pp. 3251-3259 ◽  
Author(s):  
Maria Dorly Del Curto ◽  
Alessandra Maroni ◽  
Luca Palugan ◽  
Lucia Zema ◽  
Andrea Gazzaniga ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Delivery System ◽  
Oral Delivery ◽  
Absorption Enhancer ◽  
Protein Drugs ◽  
Oral Delivery System ◽  
Colonic Release

Sterculia striata gum as a potential oral delivery system for protein drugs

2020 ◽  
Vol 164 ◽  
pp. 1683-1692
Author(s):  
Alessandra A.R. Freitas ◽  
Antonio J. Ribeiro ◽  
Ana Claudia Santos ◽  
Francisco Veiga ◽  
Livio C.C. Nunes ◽  
...  
Keyword(s):  
Delivery System ◽  
Oral Delivery ◽  
Protein Drugs ◽  
Oral Delivery System

Indomethacin-5-fluorouracil-methyl ester dry emulsion: a potential oral delivery system for 5-fluorouracil

2010 ◽  
Vol 36 (6) ◽  
pp. 647-656 ◽  
Author(s):  
Jing Wang ◽  
Yanchen Hu ◽  
Ling Li ◽  
Tongying Jiang ◽  
Siling Wang ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Delivery System ◽  
Oral Delivery ◽  
Oral Delivery System ◽  
Dry Emulsion

Solvent-free synthesis of acetylated cashew gum for oral delivery system of insulin

2019 ◽  
Vol 207 ◽  
pp. 601-608 ◽  
Author(s):  
Eliadna de Lemos Vasconcelos Silva ◽  
Antônia Carla de Jesus Oliveira ◽  
Yuri Basílio Gomes Patriota ◽  
António José Ribeiro ◽  
Francisco Veiga ◽  
...  
Keyword(s):  
Delivery System ◽  
Oral Delivery ◽  
Solvent Free ◽  
Cashew Gum ◽  
Oral Delivery System ◽  
Solvent Free Synthesis

scholarly journals Fabrication of PLA-PEG Nanoparticles as Delivery Systems for Improved Stability and Controlled Release of Catechin

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Neha Atulkumar Singh ◽  
Abul Kalam Azad Mandal ◽  
Zaved Ahmed Khan
Keyword(s):  
Controlled Release ◽  
Delivery System ◽  
Oral Delivery ◽  
Polymeric Nanoparticles ◽  
Double Emulsion ◽  
Hydrodynamic Diameter ◽  
Sem Image ◽  
Oral Delivery System ◽  
Improved Stability

The purpose of this study was to develop an oral delivery system for the controlled release of catechin and evaluate the antioxidant potential and stability of catechin loaded PLA/PEG nanoparticles (CATNP). Nanoparticles were synthesized using a double emulsion solvent evaporation method. The fabricated nanoparticles were relatively small with a hydrodynamic diameter of 300 nm and an encapsulation efficiency of 95%. SEM image analysis showed uniform sized and spherically shaped nanoparticles. In vitro release profiles indicated a slow and sustained release of catechin from the nanoparticle. Stability of the nanoparticle in simulated gastric and intestinal fluids is maintained due to the PEG coating on the nanoparticles, which effectively protected catechin against gastrointestinal enzyme activity. Enhanced inhibition action of free radicals and metal chelation potential was noted when catechin was encapsulated in these polymeric nanoparticles. The reports obtained from this study would provide an opportunity for designing an oral delivery system aimed at inhibiting oxidative stress in the human body.

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