Combined application of extrusion-spheronization and hot-melt coating technologies for improving moisture-proofing of herbal extracts

2010 ◽  
Vol 99 (5) ◽  
pp. 2444-2454 ◽  
Author(s):  
Hao Chen ◽  
Shuai Shi ◽  
Aina Liu ◽  
Xing Tang
Keyword(s):  
Herbal Extracts ◽  
Combined Application ◽  
Hot Melt ◽  
Extrusion Spheronization

scholarly journals Pelletization Techniques. The Pharma Review

2019 ◽  
pp. 690-700
Author(s):  
Harsha V Sonaye ◽  
Mohmad Rafik Y. Shaikh ◽  
Rubina Shaikh
Keyword(s):  
Dosage Form ◽  
Oral Dosage ◽  
Modified Release ◽  
Factors Affecting ◽  
Manufacturing Techniques ◽  
Extrusion Technology ◽  
High Degree ◽  
Hot Melt ◽  
Extrusion Spheronization ◽  
Binder Solution

Pellets are spherical or nearly spherical, free-flowing granules with a narrow size distribution, typically varying between 500 and 1500 µm for pharmaceutical applications. They are generally produced via a pelletization process whereby a powder blend consisting of an API and excipients particles is agglomerated into spherical granules. This review article deals with various aspects of the extrusion–spheronization technique. Pelletization is a technique to convert drugs or excipients to small free flowing, spherical or semi spherical units, which are produced by agglomerating fine powdered drugs/ excipients with a binder solution. Pellets range in size, typically, between 0.5 – 2 mm. In relation to pharmaceuticals, pellets offer high degree of flexibility in design and development of oral dosage form. Pelletization technique help in the formation of spherical beads or pellets having a diameter 0.5 -1.5 mm which can be eventually coated for preparation of modified release dosage form. The manufacturing techniques include Drug layering, Extrusion-Spheronization, Cryopelletization, Compression, Balling, Hot-Melt Extrusion Technology, Freeze pelletization, Spray-drying & Spray-congealing. Factors affecting pelletization technique and advantages, disadvantages of pellets are discussed.

In vitro evaluation of the effect of selected herbal extracts on drug transport across porcine jejunal tissue

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
C Tarirai ◽  
A Viljoen ◽  
P Chinyemba ◽  
A Khatib ◽  
P Jiyane ◽  
...  
Keyword(s):  
Drug Transport ◽  
Herbal Extracts ◽  
In Vitro Evaluation

Anti-adhesive activity of herbal extracts against Campylobacter jejuni

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
K Bensch ◽  
J Tiralongo ◽  
A Matthias ◽  
K Bone ◽  
R Lehmann ◽  
...  
Keyword(s):  
Campylobacter Jejuni ◽  
Herbal Extracts

In vitro strategy to quantify changes in hepatobiliary drug clearance by herbal extracts

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
JP Jackson ◽  
K Freeman ◽  
J Hatfield ◽  
B St Claire ◽  
C Hubert ◽  
...  
Keyword(s):  
Drug Clearance ◽  
Herbal Extracts

In vitro study of the interaction between human gut microbiota and herbal extracts using willow bark extract as an example

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
EM Pferschy-Wenzig ◽  
K Koskinen ◽  
C Moissl-Eichinger ◽  
R Bauer
Keyword(s):  
Gut Microbiota ◽  
In Vitro Study ◽  
Vitro Study ◽  
Bark Extract ◽  
Herbal Extracts ◽  
Human Gut ◽  
Human Gut Microbiota ◽  
Willow Bark

Biobehavioural effects of herbal extracts

Planta Medica ◽  
2006 ◽  
Vol 72 (11) ◽  
Author(s):  
AB Scholey ◽  
DO Kennedy
Keyword(s):  
Herbal Extracts
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