Spray Drying Technique. I: Hardware and Process Parameters

2010 ◽  
Vol 99 (2) ◽  
pp. 575-586 ◽  
Author(s):  
Krzysztof Cal ◽  
Krzysztof Sollohub
Keyword(s):  
Spray Drying ◽  
Process Parameters

scholarly journals Physico-Chemical and In Vitro Characterization of Chitosan-Based Microspheres Intended for Nasal Administration

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 608
Author(s):  
Csilla Bartos ◽  
Patrícia Varga ◽  
Piroska Szabó-Révész ◽  
Rita Ambrus
Keyword(s):  
Drug Delivery ◽  
Spray Drying ◽  
Process Parameters ◽  
Sodium Tripolyphosphate ◽  
Structural Characteristics ◽  
Nasal Administration ◽  
Drug Bioavailability ◽  
Intranasal Application ◽  
Spray Dried

The absorption of non-steroidal anti-inflammatory drugs (NSAIDs) through the nasal epithelium offers an innovative opportunity in the field of pain therapy. Thanks to the bonding of chitosan to the nasal mucosa and its permeability-enhancing effect, it is an excellent choice to formulate microspheres for the increase of drug bioavailability. The aim of our work includes the preparation of spray-dried cross-linked and non-cross-linked chitosan-based drug delivery systems for intranasal application, the optimization of spray-drying process parameters (inlet air temperature, pump rate), and the composition of samples. Cross-linked products were prepared by using different amounts of sodium tripolyphosphate. On top of these, the micrometric properties, the structural characteristics, the in vitro drug release, and the in vitro permeability of the products were studied. Spray-drying resulted in micronized chitosan particles (2–4 μm) regardless of the process parameters. The meloxicam (MEL)-containing microspheres showed nearly spherical habit, while MEL was present in a molecularly dispersed state. The highest dissolved (>90%) and permeated (~45 µg/cm2) MEL amount was detected from the non-cross-linked sample. Our results indicate that spray-dried MEL-containing chitosan microparticles may be recommended for the development of a novel drug delivery system to decrease acute pain or enhance analgesia by intranasal application.

Effect of foam spray drying process parameters on powder morphology

2018 ◽  
Vol 37 (5) ◽  
pp. 535-545 ◽  
Author(s):  
Artur Lewandowski ◽  
Maciej Jaskulski ◽  
Ireneusz Zbiciński
Keyword(s):  
Spray Drying ◽  
Process Parameters ◽  
Drying Process ◽  
Powder Morphology

Impact of Spray-Drying Process Parameters on Dairy Powder Surface Composition and Properties

2015 ◽  
Vol 33 (13) ◽  
pp. 1654-1661 ◽  
Author(s):  
Y. Nikolova ◽  
J. Petit ◽  
A. Gianfrancesco ◽  
C. F. W. Sanders ◽  
J. Scher ◽  
...  
Keyword(s):  
Spray Drying ◽  
Process Parameters ◽  
Surface Composition ◽  
Drying Process ◽  
Powder Surface

scholarly journals Effect of spray drying process parameters on Uncaria tomentosa (Willd. ex Schult.) DC. dried extracts

Revista Fitos ◽  
2020 ◽  
Vol 14 (4) ◽  
pp. 469-475
Author(s):  
Lucas Oliveira Rodrigues ◽  
Rachel Andrade de Faria ◽  
Marcos Martins Gouvêa ◽  
Carlos Augusto de Freitas Peregrino ◽  
Elizabeth Valverde Macedo ◽  
...  
Keyword(s):  
Spray Drying ◽  
Process Parameters ◽  
Inlet Temperature ◽  
Airflow Rate ◽  
Spray Nozzle ◽  
Drying Process ◽  
Process Yield ◽  
Uncaria Tomentosa ◽  
Acacia Gum ◽  
Higher Temperature

Uncaria tomentosa (Willd. ex Schult.) DC. (Cat's claw) is a plant member of the Rubiaceae family, from the Amazon region, and used in traditional medicine as raw material for phytomedicines indicated for arthritis and osteoarthritis. This study aimed to evaluate the spray drying process parameters on the properties of different extracts obtained from Uncaria tomentosa. A reduced 24-1 multifactorial design was applied to evaluate the importance of the equipment variables (pump speed, spray nozzle diameter, air inlet temperature, and atomization airflow rate) in the process. Maltodextrin and acacia gum were used as carriers in a 1:1 (m/m) ratio, considering the solid residue content of the liquid plant extract. Process yield, moisture, and hygroscopicity were evaluated as dependent variables. Higher atomization airflow rate led to higher process yield for powdered dried extracts with maltodextrin. Higher temperature led to lower moisture contents regarding powdered dried extracts with acacia gum. No variable, for any carrier, was considered significant for hygroscopicity. The best spray drying configuration for the desired characteristics (i.e. lower hygroscopicity and moisture) used the larger spray nozzle with a diameter of 1.2 mm and the higher temperature of 150 °C, with both carriers.

Synthesis of Nd2Fe14B powders by spray-drying and reduction–diffusion processes

2001 ◽  
Vol 16 (4) ◽  
pp. 1083-1089 ◽  
Author(s):  
X. L. Dong ◽  
B. K. Kim ◽  
C. J. Choi ◽  
K. S. Park ◽  
Z. D. Zhang
Keyword(s):  
Particle Size ◽  
Thermal Properties ◽  
Spray Drying ◽  
Process Parameters ◽  
Diffusion Processes ◽  
Liquid Solution ◽  
Metal Salts ◽  
Mechanochemical Method ◽  
Precursor Powders ◽  
Spray Dried

The magnetic Nd–Fe–B powders were prepared by a mechanochemical method, including the processes of spray drying, debinding, milling, H2 reduction, Ca reduction, and washing. The liquid solution dissolved with various metal salts was first spray-dried to prepare the precursor powders having uniformly dispersed Nd, Fe, and B components. The precursor powders in turn were subjected to the subsequent processes. The particle size of the resultant Nd–Fe–B powders was about 1 μm. Effects of the process parameters on phases, morphologies, microstructures, compositions, and thermal properties of the powders were investigated.

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