Effect of temperature and moisture on the miscibility of amorphous dispersions of felodipine and poly(vinyl pyrrolidone)

2010 ◽  
Vol 99 (1) ◽  
pp. 169-185 ◽  
Author(s):  
Patrick J. Marsac ◽  
Alfred C.F. Rumondor ◽  
David E. Nivens ◽  
Umesh S. Kestur ◽  
Lia Stanciu ◽  
...  
Keyword(s):  
Vinyl Pyrrolidone ◽  
Effect Of Temperature ◽  
Amorphous Dispersions ◽  
Poly Vinyl Pyrrolidone

scholarly journals Effect of temperature on the morphology of bubble-electrospun nanofibers

2014 ◽  
Vol 18 (5) ◽  
pp. 1707-1709 ◽  
Author(s):  
Qiu-Na Cui ◽  
Ya Li ◽  
Fu-Juan Liu
Keyword(s):  
Vinyl Alcohol ◽  
Smooth Surface ◽  
Electrospun Nanofibers ◽  
Vinyl Pyrrolidone ◽  
Effect Of Temperature ◽  
Poly Vinyl Alcohol ◽  
Temperature Environment ◽  
Poly Vinyl Pyrrolidone

The morphology and microstructures of poly(vinyl alcohol) and poly(vinyl pyrrolidone) nanofibers produced by bubble-electrospinning are investigated experimentally. It is shown that the temperature predominantly affect the average diameters of the formed nanofibers. The smooth surface and controllable diameters of nanofibers are essential for their applications in different temperature environment.

scholarly journals ALD coating of centrifugally spun polymeric fibers and postannealing: case study for nanotubular TiO2 photocatalyst

2021 ◽  
Author(s):  
Martina Rihova ◽  
Oksana Yurkevich ◽  
Martin Motola ◽  
Ludek Hromadko ◽  
Zdeněk Spotz ◽  
...  
Keyword(s):  
Atomic Layer Deposition ◽  
Atomic Layer ◽  
Vinyl Pyrrolidone ◽  
Tio2 Photocatalyst ◽  
Polymeric Fibers ◽  
Layer Deposition ◽  
Centrifugal Spinning ◽  
Poly Vinyl Pyrrolidone

This work describes the synthesis of highly photocatalytically active TiO2 tubes (TiTBs) by combining centrifugal spinning and atomic layer deposition (ALD). Poly(vinyl pyrrolidone) (PVP) fibers were first produced by centrifugal...

scholarly journals Potential Implantable Nanofibrous Biomaterials Combined with Stem Cells for Subchondral Bone Regeneration

Materials ◽  
2020 ◽  
Vol 13 (14) ◽  
pp. 3087
Author(s):  
Rana Smaida ◽  
Luc Pijnenburg ◽  
Silvia Irusta ◽  
Erico Himawan ◽  
Gracia Mendoza ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Regeneration ◽  
Subchondral Bone ◽  
Therapeutic Potential ◽  
Sodium Hyaluronate ◽  
Vinyl Pyrrolidone ◽  
Regenerative Ability ◽  
Poly Vinyl Pyrrolidone

The treatment of osteochondral defects remains a challenge. Four scaffolds were produced using Food and Drug Administration (FDA)-approved polymers to investigate their therapeutic potential for the regeneration of the osteochondral unit. Polycaprolactone (PCL) and poly(vinyl-pyrrolidone) (PVP) scaffolds were made by electrohydrodynamic techniques. Hydroxyapatite (HAp) and/or sodium hyaluronate (HA) can be then loaded to PCL nanofibers and/or PVP particles. The purpose of adding hydroxyapatite and sodium hyaluronate into PCL/PVP scaffolds is to increase the regenerative ability for subchondral bone and joint cartilage, respectively. Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) were seeded on these biomaterials. The biocompatibility of these biomaterials in vitro and in vivo, as well as their potential to support MSC differentiation under specific chondrogenic or osteogenic conditions, were evaluated. We show here that hBM-MSCs could proliferate and differentiate both in vitro and in vivo on these biomaterials. In addition, the PCL-HAp could effectively increase the mineralization and induce the differentiation of MSCs into osteoblasts in an osteogenic condition. These results indicate that PCL-HAp biomaterials combined with MSCs could be a beneficial candidate for subchondral bone regeneration.

scholarly journals In Vitro Drug Release, Permeability, and Structural Test of Ciprofloxacin-Loaded Nanofibers

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 556
Author(s):  
Luca Éva Uhljar ◽  
Sheng Yuan Kan ◽  
Norbert Radacsi ◽  
Vasileios Koutsos ◽  
Piroska Szabó-Révész ◽  
...  
Keyword(s):  
Amorphous State ◽  
Physical Mixture ◽  
Water Soluble ◽  
Vinyl Pyrrolidone ◽  
Amorphous Solid Dispersion ◽  
Release Mechanism ◽  
Dissolution Studies ◽  
In Vitro Diffusion ◽  
Poly Vinyl Pyrrolidone

Nanofibers of the poorly water-soluble antibiotic ciprofloxacin (CIP) were fabricated in the form of an amorphous solid dispersion by using poly(vinyl pyrrolidone) as a polymer matrix, by the low-cost electrospinning method. The solubility of the nanofibers as well as their in vitro diffusion were remarkably higher than those of the CIP powder or the physical mixture of the two components. The fiber size and morphology were optimized, and it was found that the addition of the CIP to the electrospinning solution decreased the nanofiber diameter, leading to an increased specific surface area. Structural characterization confirmed the interactions between the drug and the polymer and the amorphous state of CIP inside the nanofibers. Since the solubility of CIP is pH-dependent, the in vitro solubility and dissolution studies were executed at different pH levels. The nanofiber sample with the finest morphology demonstrated a significant increase in solubility both in water and pH 7.4 buffer. Single medium and two-stage biorelevant dissolution studies were performed, and the release mechanism was described by mathematical models. Besides, in vitro diffusion from pH 6.8 to pH 7.4 notably increased when compared with the pure drug and physical mixture. Ciprofloxacin-loaded poly(vinyl pyrrolidone) (PVP) nanofibers can be considered as fast-dissolving formulations with improved physicochemical properties.

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