Multivariate modeling of encapsulation and release of an ionizable drug from polymer microspheres

2009 ◽  
Vol 98 (12) ◽  
pp. 4603-4615 ◽  
Author(s):  
Hagar I. Labouta ◽  
Labiba K. El-Khordagui ◽  
Abdullah M. Molokhia ◽  
Ghaly M. Ghaly
Keyword(s):  
Polymer Microspheres ◽  
Multivariate Modeling ◽  
Ionizable Drug

Research Progress of Magnetic Polymer Microspheres in Environmental Engineering

2016 ◽  
Vol 13 (2) ◽  
pp. 118-125
Author(s):  
Xiang Li ◽  
Huaili Zheng ◽  
Zhengan Zhang ◽  
Chuanliang Zhao ◽  
Yuhao Zhou ◽  
...  
Keyword(s):  
Environmental Engineering ◽  
Research Progress ◽  
Polymer Microspheres

scholarly journals Dynamic mechanical behaviors of epoxy resin/hollow polymeric microsphere composite foams under forced non-resonance and forced resonance

2021 ◽  
Vol 30 ◽  
pp. 263498332110081
Author(s):  
Rui Li ◽  
Guisen Fan ◽  
Xiao Ouyang ◽  
Guojun Wang ◽  
Hao Wei
Keyword(s):  
Mechanical Properties ◽  
Epoxy Resin ◽  
Second Order ◽  
Polymer Microspheres ◽  
Hollow Glass Microsphere ◽  
Dynamic Mechanical ◽  
First Order ◽  
Composite Foams ◽  
Prepared Composite ◽  
Loss Factors

Composite foams with 10–50 vol% hollow polymeric microspheres were prepared using bisphenol A epoxy resin and polyetheramine curing agent as the matrix. The results demonstrated that the density, hardness, and static mechanical properties of the epoxy resin/hollow polymer microsphere composite foams, as well as their dynamic mechanical properties under forced non-resonance, were similar to those of polymer/hollow glass microsphere composite foams. At 25°C and under 1–100 Hz forced resonance, the first-order and second-order resonance frequencies of the composite foams shifted to the low-frequency region as the volume fraction of hollow polymer microspheres increased. Meanwhile, the first-order and second-order loss factors of the as-prepared composite foams were improved by 41.7% and 103.3%, respectively, compared with the pure epoxy resin. Additionally, the first-order and second-order loss factors of the as-prepared composite foams reached a maximum at 40 vol% and 30 vol% hollow polymer microspheres, respectively. This research helps us to expand the application range of composite foam materials in damping research.

scholarly journals In vivo tumour imaging employing regional delivery of novel gallium radiolabelled polymer composites

2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Ross W. Stephens ◽  
Gregory D. Tredwell ◽  
Jessica L. Bell ◽  
Karen J. Knox ◽  
Lee A. Philip ◽  
...  
Keyword(s):  
Normal Liver ◽  
Ct Imaging ◽  
Liver Imaging ◽  
Polymer Microspheres ◽  
Tumour Imaging ◽  
Planar Imaging ◽  
Rabbit Lung ◽  
Vitro Binding

Abstract Background Understanding the regional vascular delivery of particles to tumour sites is a prerequisite for developing new diagnostic and therapeutic composites for treatment of oncology patients. We describe a novel imageable 67Ga-radiolabelled polymer composite that is biocompatible in an animal tumour model and can be used for preclinical imaging investigations of the transit of different sized particles through arterial networks of normal and tumour-bearing organs. Results Radiolabelling of polymer microspheres with 67Ga was achieved using a simple mix and wash method, with tannic acid as an immobilising agent. Final in vitro binding yields after autoclaving averaged 94.7%. In vivo stability of the composite was demonstrated in New Zealand white rabbits by intravenous administration, and intrahepatic artery instillations were made in normal and VX2 tumour implanted rabbit livers. Stability of radiolabel was sufficient for rabbit lung and liver imaging over at least 3 hours and 1 hour respectively, with lung retention of radiolabel over 91%, and retention in both normal and VX2 implanted livers of over 95%. SPECT-CT imaging of anaesthetised animals and planar imaging of excised livers showed visible accumulation of radiolabel in tumours. Importantly, microsphere administration and complete liver dispersal was more easily achieved with 8 μm diameter MS than with 30 μm MS, and the smaller microspheres provided more distinct and localised tumour imaging. Conclusion This method of producing 67Ga-radiolabelled polymer microspheres is suitable for SPECT-CT imaging of the regional vascular delivery of microspheres to tumour sites in animal models. Sharper distinction of model tumours from normal liver was obtained with smaller MS, and tumour resolution may be further improved by the use of 68Ga instead of 67Ga, to enable PET imaging.

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