Ordered Mesoporous Silica Material SBA-15: A Broad-Spectrum Formulation Platform for Poorly Soluble Drugs

2009 ◽  
Vol 98 (8) ◽  
pp. 2648-2658 ◽  
Author(s):  
Michiel Van Speybroeck ◽  
Valéry Barillaro ◽  
Thao Do Thi ◽  
Randy Mellaerts ◽  
Johan Martens ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Broad Spectrum ◽  
Ordered Mesoporous Silica ◽  
Poorly Soluble Drugs ◽  
Mesoporous Silica Material ◽  
Silica Material ◽  
Ordered Mesoporous ◽  
Poorly Soluble

Molecular organization of hydrophobic molecules and co-adsorbed water in SBA-15 ordered mesoporous silica material

2011 ◽  
Vol 13 (7) ◽  
pp. 2706-2713 ◽  
Author(s):  
Randy Mellaerts ◽  
Maarten B. J. Roeffaers ◽  
Kristof Houthoofd ◽  
Michiel Van Speybroeck ◽  
Gert De Cremer ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Adsorbed Water ◽  
Molecular Organization ◽  
Ordered Mesoporous Silica ◽  
Mesoporous Silica Material ◽  
Silica Material ◽  
Ordered Mesoporous

Potential of ordered mesoporous silica for oral delivery of poorly soluble drugs

2011 ◽  
Vol 2 (8) ◽  
pp. 1079-1091 ◽  
Author(s):  
Monica Vialpando ◽  
Johan A Martens ◽  
Guy Van den Mooter
Keyword(s):  
Mesoporous Silica ◽  
Oral Delivery ◽  
Ordered Mesoporous Silica ◽  
Poorly Soluble Drugs ◽  
Ordered Mesoporous ◽  
Poorly Soluble

Synthesis of octyl-modified ordered mesoporous silica as a new nano sorbent for the removal of 2-chlorophenol from aqueous media

2012 ◽  
Vol 12 (3) ◽  
pp. 259-269 ◽  
Author(s):  
Dongmei Zhang ◽  
Zhonglin Chen ◽  
Jimin Shen ◽  
Lei Yang
Keyword(s):  
Experimental Data ◽  
Humic Acid ◽  
Ionic Strength ◽  
Mesoporous Silica ◽  
Aqueous Media ◽  
Ordered Mesoporous Silica ◽  
Desorption Process ◽  
Mesoporous Silica Material ◽  
Silica Material ◽  
Ordered Mesoporous

Adsorption of 2-chlorophenol onto octyl-modified ordered mesoporous silica material from an aqueous solution was investigated systematically using batch experiments in this study. Hexagonal mesoporous silica (HMS) owning double pore paths and OD-HMS were synthesized by using cheap sodium silicate and a non-ion surfactant C16PyCl under room temperature here and characterized by X-ray diffraction (XRD), N2 adsorption–desorption measurement, and Fourier Transform-Infrared (FT-IR). Results indicate that 2-chlorophenol adsorption is initially rapid and the adsorption process reaches a steady state after 5 min. The adsorption isotherms are well described by the Langmuir and the Freundlich models, the former being found to provide a better fit with the experimental data. The effects of temperature, pH, ionic strength, and humic acid on the adsorption are also examined. According to the experimental results, the amount of 2-chlorophenol adsorbed decreases with increases of temperature from 288 to 308 K, and pH from 2.0 to 11.0, the amount of 2-chlorophenol adsorbed increases with an increase of ionic strength from 0.001 to 0.1 mol/L. However, the amount of 2-chlorophenol adsorbed onto octyl-modified ordered mesoporous silica material shows notable difference in the presence of humic acid. The desorption process shows a reversibility of 2-chlorophenol adsorption onto octyl-modified ordered mesoporous silica material. Thermodynamic parameters such as Gibbs free energy are calculated from the experimental data at different temperatures. Based on the results, It was found that octyl-modified ordered mesoporous silica shows significant adsorption for 2-chlorophenol. This might be due to hydrophobic interaction among the octyl functional groups and 2-chlorophenol.

Fluorescence chemosensors based on functionalized SBA-15 for detection of Pb2+ in aqueous media

RSC Advances ◽  
2015 ◽  
Vol 5 (21) ◽  
pp. 16611-16617 ◽  
Author(s):  
Liyan Zhao ◽  
Dan Sui ◽  
Yan Wang
Keyword(s):  
Mesoporous Silica ◽  
Aqueous Media ◽  
Ordered Mesoporous Silica ◽  
Mesoporous Silica Material ◽  
Silica Material ◽  
Ordered Mesoporous

A highly ordered mesoporous silica material (SBA-15) functionalized with 5-(4-carboxy-phenylazo)-8-hydroxyquinoline (CPA-8-HQL) for use as a fluorescence chemosensor for Pb2+ detection has been reported in this study.

In Situ FT-IR Investigation of Etravirine Speciation in Pores of SBA-15 Ordered Mesoporous Silica Material upon Contact with Water

2013 ◽  
Vol 10 (2) ◽  
pp. 567-573 ◽  
Author(s):  
Randy Mellaerts ◽  
Elie J. Fayad ◽  
Guy Van den Mooter ◽  
Patrick Augustijns ◽  
Mickaël Rivallan ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Ordered Mesoporous Silica ◽  
Mesoporous Silica Material ◽  
Silica Material ◽  
Ordered Mesoporous ◽  
Ft Ir

Evaluation of ordered mesoporous silica as a carrier for poorly soluble drugs: Influence of pressure on the structure and drug release

2011 ◽  
Vol 100 (8) ◽  
pp. 3411-3420 ◽  
Author(s):  
Monica Vialpando ◽  
Alexander Aerts ◽  
Jeroen Persoons ◽  
Johan Martens ◽  
Guy Van Den Mooter
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Ordered Mesoporous Silica ◽  
Poorly Soluble Drugs ◽  
Ordered Mesoporous ◽  
Poorly Soluble
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