Design and evaluation of polymeric coated minitablets as multiple unit gastroretentive floating drug delivery systems for furosemide

2009 ◽  
Vol 98 (6) ◽  
pp. 2122-2132 ◽  
Author(s):  
Lingam Meka ◽  
Bhaskar Kesavan ◽  
Venkatasimhadri Naidu Kalamata ◽  
Chandra Mohan Eaga ◽  
Suresh Bandari ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Floating Drug Delivery ◽  
Multiple Unit ◽  
Floating Drug Delivery Systems

Floating Drug Delivery Systems

2009 ◽  
Vol 2 (3) ◽  
pp. 595-604
Author(s):  
Jagadeesh Nadigoti ◽  
Shayeda
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
New Era ◽  
Gastric Residence Time ◽  
Floating Drug Delivery ◽  
Recent Developments ◽  
Multiple Unit ◽  
Novel Drug ◽  
Floating Drug Delivery Systems

Management of illness through medication is entering a new era in which growing number of novel drug delivery systems are being employed and are available for therapeutic use. Oral sustained release gastro-retentive dosage forms (GRDFs) offer many advantages for drugs with absorption from upper parts of gastrointestinal tract and for those acting locally in the stomach, improving the bioavailability of the medication. Floating Drug Delivery Systems (FDDS) is one amongst the GRDFs used to achieve prolonged gastric residence time. Multiple unit FDDS avoid “all-or-nothing” gastric emptying nature of single unit systems. Apart from the background, formulation aspects and evaluation of FDDS, recent developments are also covered in this review.

scholarly journals Floating drug delivery system- a review

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
Sharma Anjali ◽  
Sharma Devkant
Keyword(s):  
Drug Delivery ◽  
Gastric Emptying ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Gastric Retention ◽  
Residence Times ◽  
Principal Mechanism ◽  
Floating Drug Delivery ◽  
Floating Systems ◽  
Floating Drug Delivery Systems

In the recent years, scientific and technological advancements have been made in the research and development of novel drug delivery systems by overcoming various physiological problems such as short gastric residence times and unpredictable gastric emptying times. Several approaches are utilized in the prolongation of the gastric residence times, such as floating drug delivery systems, swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems and other delayed gastric emptying devices. Floating Drug Delivery Systems (FDDS) is one amongst the GRDFs used to achieve prolonged gastric residence time. The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the in-vitro techniques, in- vivo studies to evaluate the performance and application of floating systems, and applications of these systems.

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