Dry Powder Formulations for Inhalation of Fluticasone Propionate and Salmeterol Xinafoate Microcrystals

2009 ◽  
Vol 98 (2) ◽  
pp. 503-515 ◽  
Author(s):  
Darragh Murnane ◽  
Gary P. Martin ◽  
Christopher Marriott
Keyword(s):  
Fluticasone Propionate ◽  
Dry Powder ◽  
Salmeterol Xinafoate ◽  
Dry Powder Formulations

Adrenal Suppression with Dry Powder Formulations of Fluticasone Propionate and Mometasone Furoate

2004 ◽  
Vol 170 (9) ◽  
pp. 960-966 ◽  
Author(s):  
Tom C. Fardon ◽  
Daniel K. C. Lee ◽  
Kay Haggart ◽  
Lesley C. McFarlane ◽  
Brian J. Lipworth
Keyword(s):  
Fluticasone Propionate ◽  
Mometasone Furoate ◽  
Adrenal Suppression ◽  
Dry Powder ◽  
Dry Powder Formulations

Formulation of novel dry powder inhalation for fluticasone propionate and salmeterol xinafoate with capsule-based device

2017 ◽  
Vol 23 (2) ◽  
pp. 158-166 ◽  
Author(s):  
Kyeong Soo Kim ◽  
Jeong Hyun Kim ◽  
Sung Giu Jin ◽  
Dong Wuk Kim ◽  
Jong Oh Kim ◽  
...  
Keyword(s):  
Fluticasone Propionate ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Salmeterol Xinafoate

A generic fluticasone propionate and salmeterol dry powder inhaler: Evidence of usability, function, and robustness

2021 ◽  
Vol 42 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Donald P. Tashkin ◽  
Arkady Koltun ◽  
Róisín Wallace
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Fluticasone Propionate ◽  
Healthy Volunteers ◽  
Pulmonary Disease ◽  
Dry Powder Inhaler ◽  
Chemical Degradation ◽  
Chronic Obstructive ◽  
Dry Powder ◽  
Obstructive Pulmonary Disease ◽  
Flow Rates

Background: A generic combination of fluticasone propionate and salmeterol xinafoate inhalation powder in a premetered, multidose, nonreusable inhaler was recently approved. Objective: To assess the performance of the generic device. Methods: Findings from three studies with regard to device usability, function, and robustness were reviewed. Results: In a study to assess device function in patients and healthy volunteers, the generic device was successfully used by patients with asthma and chronic obstructive pulmonary disease who were either dry powder inhaler users or dry powder inhaler‐naive, even though they were not trained beyond being provided the instructions for use. In a study to measure inhaled flow rates generated by patients and healthy volunteers, the generic device consistently simulated the delivery of a full dose of drug, even to patients with severe respiratory disease and reduced inspiratory flow rates. Although the generic device had a slightly higher airflow resistance, this study demonstrated that this difference did not result in any clinically meaningful differences in terms of drug delivery. Pressure drop, a key parameter that drives the fluidization and aerosolization of the powder dose, was found to be comparable between the devices. In an open-label study, the generic device met all U.S. Food and Drug Administration specifications for device robustness after 21.5 days of twice-daily dosing via oral inhalation among 111 participants with asthma or chronic obstructive pulmonary disease. All inhalers tested demonstrated conformity with a pharmacopeia with respect to key quality parameters (assay, delivered dose uniformity, aerodynamic size distribution). There was no evidence of chemical degradation of the active ingredients, nor of microbial or water ingress into the powder, as a result of inhaler use.

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