Use of hydrodynamic flow focusing for the generation of biodegradable camptothecin‐loaded polymer microspheres

2008 ◽  
Vol 97 (11) ◽  
pp. 4943-4954 ◽  
Author(s):  
Thomas Schneider ◽  
Hong Zhao ◽  
John K. Jackson ◽  
Glenn H. Chapman ◽  
James Dykes ◽  
...  
Keyword(s):  
Hydrodynamic Flow ◽  
Polymer Microspheres ◽  
Flow Focusing

scholarly journals A 3D hydrodynamic flow-focusing device for cell sorting

2021 ◽  
Vol 25 (3) ◽  
Author(s):  
Xiaofei Yuan ◽  
Andrew Glidle ◽  
Hitoshi Furusho ◽  
Huabing Yin
Keyword(s):  
Cell Sorting ◽  
Control Strategies ◽  
Three Dimensional ◽  
Hydrodynamic Flow ◽  
Proof Of Concept ◽  
Flow Focusing ◽  
Hydrodynamic Focusing ◽  
Cell Handling ◽  
Fluid Flow Control ◽  
High Degree

AbstractOptical-based microfluidic cell sorting has become increasingly attractive for applications in life and environmental sciences due to its ability of sophisticated cell handling in flow. The majority of these microfluidic cell sorting devices employ two-dimensional fluid flow control strategies, which lack the ability to manipulate the position of cells arbitrarily for precise optical detection, therefore resulting in reduced sorting accuracy and purity. Although three-dimensional (3D) hydrodynamic devices have better flow-focusing characteristics, most lack the flexibility to arbitrarily position the sample flow in each direction. Thus, there have been very few studies using 3D hydrodynamic flow focusing for sorting. Herein, we designed a 3D hydrodynamic focusing sorting platform based on independent sheath flow-focusing and pressure-actuated switching. This design offers many advantages in terms of reliable acquisition of weak Raman signals due to the ability to precisely control the speed and position of samples in 3D. With a proof-of-concept demonstration, we show this 3D hydrodynamic focusing-based sorting device has the potential to reach a high degree of accuracy for Raman activated sorting.

Design, characterization and application of a novel mono-layer pin-microvalve for microfluidic devices

RSC Advances ◽  
2014 ◽  
Vol 4 (46) ◽  
pp. 24394-24398 ◽  
Author(s):  
Mahyar Nasabi ◽  
Masoomeh Tehranirokh ◽  
Francisco Javier Tovar-Lopez ◽  
Abbas Kouzani ◽  
Khashayar Khoshmanesh ◽  
...  
Keyword(s):  
Microfluidic Devices ◽  
Hydrodynamic Flow ◽  
Flow Focusing ◽  
Mono Layer

We introduce a novel manual pin-valve which can operate in both analogue (partially close) and digital (on/off) states. We also demonstrate implementation of this pin-valve in a hydrodynamic flow focusing (HFF) device.

scholarly journals Patterning of cell-instructive hydrogels by hydrodynamic flow focusing

Lab on a Chip ◽  
2013 ◽  
Vol 13 (11) ◽  
pp. 2099 ◽  
Author(s):  
Steffen Cosson ◽  
Simone Allazetta ◽  
Matthias P. Lutolf
Keyword(s):  
Hydrodynamic Flow ◽  
Flow Focusing

scholarly journals Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels

2011 ◽  
Vol 23 (12) ◽  
pp. H79-H83 ◽  
Author(s):  
Minsoung Rhee ◽  
Pedro M. Valencia ◽  
Maria I. Rodriguez ◽  
Robert Langer ◽  
Omid C. Farokhzad ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
Single Layer ◽  
Hydrodynamic Flow ◽  
Flow Focusing

Controllable formation of aromatic nanoparticles in a three-dimensional hydrodynamic flow focusing microfluidic device

RSC Advances ◽  
2013 ◽  
Vol 3 (39) ◽  
pp. 17762 ◽  
Author(s):  
Liguo Jiang ◽  
Weiping Wang ◽  
Ying Chau ◽  
Shuhuai Yao
Keyword(s):  
Microfluidic Device ◽  
Three Dimensional ◽  
Hydrodynamic Flow ◽  
Flow Focusing

High-throughput continuous production of liposomes using hydrodynamic flow-focusing microfluidic devices

2017 ◽  
Vol 156 ◽  
pp. 349-357 ◽  
Author(s):  
Mariano Michelon ◽  
Davi Rocha Bernardes Oliveira ◽  
Guilherme de Figueiredo Furtado ◽  
Lucimara Gaziola de la Torre ◽  
Rosiane Lopes Cunha
Keyword(s):  
High Throughput ◽  
Continuous Production ◽  
Microfluidic Devices ◽  
Hydrodynamic Flow ◽  
Flow Focusing
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