In Situ Gelling Hydrogels Incorporating Microparticles as Drug Delivery Carriers for Regenerative Medicine

2008 ◽  
Vol 97 (9) ◽  
pp. 3972-3980 ◽  
Author(s):  
Qingpu Hou ◽  
David Y.S. Chau ◽  
Chayanin Pratoomsoot ◽  
Patrick J. Tighe ◽  
Harminder S. Dua ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Regenerative Medicine ◽  
In Situ Gelling

scholarly journals In-vivo Evaluation and Characterization of Novel In-Situ Gelling System as Controlled Delivery System Containing Ciprofloxacin for Ocular Drug Delivery

2020 ◽  
Vol 10 (5-s) ◽  
pp. 32-39
Author(s):  
Fatima Eram ◽  
, Vivek
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Average Concentration ◽  
Posterior Segment ◽  
Ocular Infection ◽  
In Vivo Evaluation ◽  
Micro Emulsion ◽  
In Situ Gelling

Objectives: The purpose of this research was to develop the micro emulsion-based in situ gelling systems containing Ciprofloxacin for prophylaxis and treatment of the posterior segment diseases like endophthalmitis. Methods: Ciprofloxacin was encapsulated in small droplets owing to form microemulsion, and then the formed droplets were dispersed in a polymer solution that converted into a gel upon triggered by the electrolyte present in the tear fluid. Results: The formulation approach provides better absorption, penetration, retention, and improves the bioavailability of the drug. The average concentration reached into vitreous humor from topical microemulsion in situ gelling formulation was ~0.4 µg/ml, which is far more than the concentration required for therapeutic effect (i.e.  >0.047 µg/ml or >MIC90 for S. Epidermidis, a pathogen commonly responsible to cause endophthalmitis). Conclusion: Thus, novel micro emulsion-based in situ gelling formulation could be a potential drug delivery system for the treatment of posterior segment diseases like endophthalmitis. Keywords: Microemulsion, ciprofloxacin, endophthalmitis, ocular, infection, in situ

scholarly journals Thermosensitive PEG–PCL–PEG (PECE) hydrogel as an in situ gelling system for ocular drug delivery of diclofenac sodium

Drug Delivery ◽  
2014 ◽  
Vol 23 (1) ◽  
pp. 63-68 ◽  
Author(s):  
Zichao Luo ◽  
Ling Jin ◽  
Lu Xu ◽  
Zhao Liang Zhang ◽  
Jing Yu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Diclofenac Sodium ◽  
Ocular Drug Delivery ◽  
In Situ Gelling

In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery

2008 ◽  
Vol 127 (3) ◽  
pp. 189-207 ◽  
Author(s):  
Chaoliang He ◽  
Sung Wan Kim ◽  
Doo Sung Lee
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Stimuli Sensitive ◽  
In Situ Gelling

In situ gelling polyvalerolactone-based thermosensitive hydrogel for sustained drug delivery

2014 ◽  
Vol 88 (2) ◽  
pp. 397-405 ◽  
Author(s):  
Gyan P. Mishra ◽  
Reid Kinser ◽  
Igor H. Wierzbicki ◽  
Raid G. Alany ◽  
Adam W.G. Alani
Keyword(s):  
Drug Delivery ◽  
Thermosensitive Hydrogel ◽  
Sustained Drug Delivery ◽  
In Situ Gelling

scholarly journals In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery

2016 ◽  
Vol 502 (1-2) ◽  
pp. 70-79 ◽  
Author(s):  
Kosai Al Khateb ◽  
Elvira K. Ozhmukhametova ◽  
Marat N. Mussin ◽  
Serzhan K. Seilkhanov ◽  
Tolebai K. Rakhypbekov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ocular Drug Delivery ◽  
Pluronic F127 ◽  
Pluronic F68 ◽  
In Situ Gelling

Effect of carrageenan and potassium chloride on an in situ gelling ophthalmic drug delivery system based on methylcellulose

RSC Advances ◽  
2015 ◽  
Vol 5 (74) ◽  
pp. 60386-60391 ◽  
Author(s):  
Biplab Bhowmick ◽  
Gunjan Sarkar ◽  
Dipak Rana ◽  
Indranil Roy ◽  
Nayan Ranjan Saha ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Potassium Chloride ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Model Drug ◽  
In Situ Gelling ◽  
Ophthalmic Formulation

Our research is devoted to developing a methylcellulose (MC) basedin situgelling ophthalmic formulation using pilocarpine hydrochloride as a model drug, containing different proportions of i (iota)-carrageenan and potassium chloride.

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