Quantifying Effects of Particulate Properties on Powder Flow Properties Using a Ring Shear Tester

2008 ◽  
Vol 97 (9) ◽  
pp. 4030-4039 ◽  
Author(s):  
Hao Hou ◽  
Changquan Calvin Sun
2015 ◽  
Vol 19 (7) ◽  
pp. 1475-1482 ◽  
Author(s):  
Katarina Slettengren ◽  
Epameinondas Xanthakis ◽  
Lilia Ahrné ◽  
Erich J. Windhab

2019 ◽  
Vol 108 (1) ◽  
pp. 750-754 ◽  
Author(s):  
Tatum Swize ◽  
Frederick Osei-Yeboah ◽  
Matthew L. Peterson ◽  
Pierre Boulas

2013 ◽  
Vol 39 (9) ◽  
pp. 1464-1475 ◽  
Author(s):  
Juan G. Osorio ◽  
Fernando J. Muzzio
Keyword(s):  

Author(s):  
Chenguang Wang ◽  
Sichen Song ◽  
Chamara A. Gunawardana ◽  
David J. Sun ◽  
Changquan Calvin Sun
Keyword(s):  

2019 ◽  
Vol 344 ◽  
pp. 363-372 ◽  
Author(s):  
Camila G. Jange ◽  
R.P. Kingsly Ambrose

2011 ◽  
Vol 413 (1-2) ◽  
pp. 36-43 ◽  
Author(s):  
Qi (Tony) Zhou ◽  
Li Qu ◽  
Thomas Gengenbach ◽  
John A. Denman ◽  
Ian Larson ◽  
...  

2015 ◽  
Vol 51 (1) ◽  
pp. 155-171 ◽  
Author(s):  
Daniel García Ramírez ◽  
Leopoldo Villafuerte Robles

Specific values of technological properties of excipients allow the establishment of numerical parameters to define and compare their functionality. This study investigates the functionality of Polyplasdones XL and XL10. Parameters studied included tablet disintegration profiles, compactibility profiles and powder flow. The results allowed the establishment of quantitative surrogate functionalities of technological performance, such as absolute number, and as a value relative to the known microcrystalline cellulose type 102. Moreover, the establishment of an explicit functionality to improve the technological performance of two diluents and a model drug was investigated, as was setting up of these functionalities, as quantitative values, to determine the input variables of each material and its probable functionality in a drug product. Disintegration times of pure Polyplasdone XL and its admixtures were around half that of Polyplasdone XL10. The improvement in tablet compactibility was 25-50% greater for Polyplasdone XL10 than Polyplasdone XL. Crospovidones proportions of up to 10% have little effect on the flow properties of other powders, although pure Polyplasdone XL10 and its admixtures display compressibility indexes about 20% greater than Polyplasdone XL. The observed results are in line with a smaller particle size of Polyplasdone XL10 compared to Polyplasdone XL.


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