Drug–polymer interaction and its significance on the physical stability of nifedipine amorphous dispersion in microparticles of an ammonio methacrylate copolymer and ethylcellulose binary blend

2008 ◽  
Vol 97 (1) ◽  
pp. 251-262 ◽  
Author(s):  
Jingjun Huang ◽  
Rodney J. Wigent ◽  
Joseph B. Schwartz
Keyword(s):  
Physical Stability ◽  
Binary Blend ◽  
Methacrylate Copolymer ◽  
Drug Polymer Interaction ◽  
Polymer Interaction ◽  
Amorphous Dispersion

Impact of Drug-Polymer Interaction in Amorphous Solid Dispersion Aiming for the Supersaturation of Poorly Soluble Drug in Biorelevant Medium

2020 ◽  
Vol 21 (5) ◽  
Author(s):  
Cassiana Mendes ◽  
Rafael G. Andrzejewski ◽  
Juliana M. O. Pinto ◽  
Leice M. R. de Novais ◽  
Andersson Barison ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion ◽  
Poorly Soluble ◽  
Poorly Soluble Drug ◽  
Drug Polymer Interaction ◽  
Biorelevant Medium ◽  
Polymer Interaction

scholarly journals Drug release from thin films encapsulated by a temperature-responsive hydrogel

Soft Matter ◽  
2019 ◽  
Vol 15 (8) ◽  
pp. 1853-1859 ◽  
Author(s):  
Oliver Werzer ◽  
Stephan Tumphart ◽  
Roman Keimel ◽  
Paul Christian ◽  
Anna Maria Coclite
Keyword(s):  
Thin Films ◽  
Controlled Release ◽  
Drug Release ◽  
Temperature Responsive ◽  
Temperature Controlled ◽  
Drug Polymer Interaction ◽  
Polymer Interaction

Temperature-controlled release and study on the effects of the drug–polymer interaction and pH.

scholarly journals Development and Optimization of Quinapril Fast Dissolving Oral Films

2018 ◽  
Vol 10 (4) ◽  
Author(s):  
P. Vamsee Kumar ◽  
Y. Shravan Kumar
Keyword(s):  
In Vitro Dissolution ◽  
Onset Of Action ◽  
Disintegration Time ◽  
Efficient Management ◽  
Weight Variation ◽  
Drug Polymer Interaction ◽  
Oral Films ◽  
Evaluation Parameters ◽  
Polymer Interaction

In current investigation an attempt has been made to formulate and evaluate Quinapril mouth dissolving films using HPMC 50cps, E5, E15 and in combination of Pullulan by Solvent evaporation method. Sodium starch glycolate acts as a super disintegrating agent and it is shown that as the concentration of the super disintegrates increases the disintegration time decreases. The films were evaluated for weight variation, surface pH, folding endurance, drug content, dissolving time, disintegration time, and in-vitro dissolution studies. Based on the evaluation parameters F17 was to be optimized formulation. The optimized film (F17) showed the more drug release i.e 99.40 ± 5.30% within 7 min, lowest in vitro disintegration time 10 sec. FTIR studies proved no drug polymer interaction takes place. These results revealed that fast dissolving films of Quinapril could be formulated for quick onset of action which is required in the efficient management of hypertension.

scholarly journals Development and evaluation of a chronotherapeutic drug delivery system of torsemide

2011 ◽  
Vol 47 (3) ◽  
pp. 593-600 ◽  
Author(s):  
Songa Ambedkar Sunil ◽  
Nali Sreenivasa Rao ◽  
Meka Venkata Srikanth ◽  
Michael Uwumagbe Uhumwangho ◽  
Kommana Srinivas Phani Kumar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Lag Time ◽  
Delivery Systems ◽  
Burst Release ◽  
Treatment Of Hypertension ◽  
Drug Polymer Interaction ◽  
Compression Coating ◽  
Core Tablet ◽  
Polymer Interaction

The objective of this study was to prepare and evaluate chronotherapeutic drug delivery systems (ChrDDs) of torsemide. Compression coated tablets (CCT) containing torsemide in the core tablet were prepared by the compression coating technique with different grades of polyethylene oxide (PEO WSR 301 & 1105). The optimized formulations were characterised for tabletting parameters and drug polymer interaction by Fourier-Transform Infrared Spectroscopy (FTIR).The hardness of all the CCT using PEO WSR 301 & PEO WSR 1105 were in the range 6-8 kg/cm² & 5.5 to 7 kg/cm² respectively. Their friability values were <0.3%. All the CCT showed a clear lag time but finalized as per the predetermined lag time. As the amount of PEO was increased in the outer layer the drug released was delayed. The drug content of all the CCT was >99%. The FTIR studies showed no interaction throughout the process of development. Formulations of F7 and of P7 were considered optimized formulations since they yielded a predetermined lag time of 6h before burst release. Hence, these formulations can be exploited to achieve chronotherapeutic drug delivery systems of Torsemide for the treatment of hypertension at the time the patient needs it.

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