Significant differences in the disposition of cyclic prodrugs of opioid peptides in rats and guinea pigs following IV administration

2005 ◽  
Vol 94 (12) ◽  
pp. 2676-2687 ◽  
Author(s):  
Bianca M. Liederer ◽  
Kimthoa t. Phan ◽  
Hui ouyang ◽  
Ronald T. Borchardt
Keyword(s):  
Opioid Peptides ◽  
Guinea Pigs ◽  
Cyclic Prodrugs

ChemInform Abstract: Synthesis of Coumarin-Based, Esterase-Sensitive Cyclic Prodrugs of Opioid Peptides with Enhanced Membrane Permeability and Enzymic Stability

ChemInform ◽  
2010 ◽  
Vol 31 (32) ◽  
pp. no-no
Author(s):  
Binghe Wang ◽  
Daxian Shan ◽  
Wei Wang ◽  
Huijuan Zhang ◽  
Olafur Gudmundsson ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Opioid Peptides ◽  
Cyclic Prodrugs

The effect of conformation of the acyloxyalkoxy‐based cyclic prodrugs of opioid peptides on their membrane permeability

1999 ◽  
Vol 53 (4) ◽  
pp. 403-413 ◽  
Author(s):  
O.S. Gudmundsson ◽  
D.G. Vander Velde ◽  
S.D.S. Jois ◽  
A. Bak ◽  
T.J. Siahaan ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Opioid Peptides ◽  
Cyclic Prodrugs

The effect of conformation on the membrane permeation of coumarinic acid‐ and phenylpropionic acid‐based cyclic prodrugs of opioid peptides

1999 ◽  
Vol 53 (4) ◽  
pp. 383-392 ◽  
Author(s):  
O.S. Gudmundsson ◽  
S. D. S. Jois ◽  
D. G. Vander Velde ◽  
T.J. Siahaan ◽  
R.T. Borchardt ◽  
...  
Keyword(s):  
Opioid Peptides ◽  
Membrane Permeation ◽  
Phenylpropionic Acid ◽  
Cyclic Prodrugs

Effects of Amino Acid Chirality and the Chemical Linker on the Cell Permeation Characteristics of Cyclic Prodrugs of Opioid Peptides

2006 ◽  
Vol 49 (4) ◽  
pp. 1261-1270 ◽  
Author(s):  
Bianca M. Liederer ◽  
Tarra Fuchs ◽  
David Vander Velde ◽  
Teruna J. Siahaan ◽  
Ronald T. Borchardt
Keyword(s):  
Amino Acid ◽  
Opioid Peptides ◽  
Cyclic Prodrugs

Investigation of the relaxant effects of propofol on ovalbumin-induced asthma in guinea pigs

2006 ◽  
pp. 1
Author(s):  
I. Bagcivan ◽  
O. Cevit ◽  
M. K. Yildirim ◽  
S. Gursoy ◽  
S. Yildirim ◽  
...  
Keyword(s):  
Guinea Pigs

Hepatocyte Alterations in Guinea Pigs FED Polychlorinated Biphenyls (PCBs), Dibenzodioxins (PCDD), AND DIBENZOFURANS (PCDF)

1982 ◽  
Vol 40 ◽  
pp. 56-57
Author(s):  
J. N. Turner ◽  
D. N. Collins
Keyword(s):  
Guinea Pigs ◽  
Room Temperature ◽  
Dose Group ◽  
Methyl Cellulose ◽  
Uranyl Acetate ◽  
Target Organ ◽  
Office Building ◽  
Lead Citrate ◽  
Control Groups ◽  
Cooling Fluid

A fire involving an electric service transformer and its cooling fluid, a mixture of PCBs and chlorinated benzenes, contaminated an office building with a fine soot. Chemical analysis showed PCDDs and PCDFs including the highly toxic tetra isomers. Guinea pigs were chosen as an experimental animal to test the soot's toxicity because of their sensitivity to these compounds, and the liver was examined because it is a target organ. The soot was suspended in 0.75% methyl cellulose and administered in a single dose by gavage at levels of 1,10,100, and 500mgm soot/kgm body weight. Each dose group was composed of 6 males and 6 females. Control groups included 12 (6 male, 6 female) animals fed activated carbon in methyl cellulose, 6 males fed methyl cellulose, and 16 males and 10 females untreated. The guinea pigs were sacrificed at 42 days by suffocation in CO2. Liver samples were immediately immersed and minced in 2% gluteraldehyde in cacadylate buffer at pH 7.4 and 4°C. After overnight fixation, samples were postfixed in 1% OsO4 in cacodylate for 1 hr at room temperature, embedded in epon, sectioned and stained with uranyl acetate and lead citrate.

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