Physiologically Based Pharmacokinetic Modeling 1: Predicting the Tissue Distribution of Moderate-to-Strong Bases

Trudy Rodgers; David Leahy; Malcolm Rowland

doi:10.1002/jps.20322

Physiologically Based Pharmacokinetic Modeling 1: Predicting the Tissue Distribution of Moderate-to-Strong Bases

Journal of Pharmaceutical Sciences ◽

10.1002/jps.20322 ◽

2005 ◽

Vol 94 (6) ◽

pp. 1259-1276 ◽

Cited By ~ 428

Author(s):

Trudy Rodgers ◽

David Leahy ◽

Malcolm Rowland

Keyword(s):

Tissue Distribution ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling and Tissue Distribution Characteristics of SHetA2 in Tumor-Bearing Mice

The AAPS Journal ◽

10.1208/s12248-020-0421-z ◽

2020 ◽

Vol 22 (2) ◽

Author(s):

Ankur Sharma ◽

Mengjie Li ◽

Elangovan Thavathiru ◽

Mariam Ibrahim ◽

Lucila Garcia-Contreras ◽

...

Keyword(s):

Tissue Distribution ◽

Pharmacokinetic Modeling ◽

Distribution Characteristics ◽

Physiologically Based Pharmacokinetic Modeling ◽

Tumor Bearing ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Rodgers T, Rowland M. 2006. Physiologically‐based Pharmacokinetic Modeling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci 95:1238–1257.

Journal of Pharmaceutical Sciences ◽

10.1002/jps.20857 ◽

2007 ◽

Vol 96 (11) ◽

pp. 3153-3154 ◽

Cited By ~ 5

Author(s):

Trudy Rodgers ◽

Malcolm Rowland

Keyword(s):

Tissue Distribution ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Weak Bases ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Prediction of human pharmacokinetics and tissue distribution of apicidin, a potent histone deacetylase inhibitor, by physiologically based pharmacokinetic modeling

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-010-1502-y ◽

2010 ◽

Vol 68 (2) ◽

pp. 465-475 ◽

Cited By ~ 6

Author(s):

Beom Soo Shin ◽

Jürgen B. Bulitta ◽

Joseph P. Balthasar ◽

Minki Kim ◽

Yohan Choi ◽

...

Keyword(s):

Tissue Distribution ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Pharmacokinetic Modeling ◽

Human Pharmacokinetics ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Deacetylase Inhibitor ◽

Physiologically Based

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Estimation of placental and lactational transfer and tissue distribution of atrazine and its main metabolites in rodent dams, fetuses, and neonates with physiologically based pharmacokinetic modeling

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2013.08.010 ◽

2013 ◽

Vol 273 (1) ◽

pp. 140-158 ◽

Cited By ~ 34

Author(s):

Zhoumeng Lin ◽

Jeffrey W. Fisher ◽

Ran Wang ◽

Matthew K. Ross ◽

Nikolay M. Filipov

Keyword(s):

Tissue Distribution ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Lactational Transfer

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Interspecies prediction of pharmacokinetics and tissue distribution of doxorubicin by physiologically‐based pharmacokinetic modeling

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2229 ◽

2020 ◽

Vol 41 (4-5) ◽

pp. 192-205

Author(s):

Jong Bong Lee ◽

Simon Zhou ◽

Manting Chiang ◽

Xiaowei Zang ◽

Tae Hwan Kim ◽

...

Keyword(s):

Tissue Distribution ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Rodgers T, Leahy D, Rowland M. 2005. Physiologically based pharmacokinetic modeling 1: Predicting the tissue distribution of moderate‐to‐strong bases. J Pharm Sci 94:1259–1276.

Journal of Pharmaceutical Sciences ◽

10.1002/jps.20856 ◽

2007 ◽

Vol 96 (11) ◽

pp. 3151-3152 ◽

Cited By ~ 5

Author(s):

Trudy Rodgers ◽

David Leahy ◽

Malcolm Rowland

Keyword(s):

Tissue Distribution ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Physiologically-based pharmacokinetic modeling of different size polyethylene glycol-coated gold nanoparticles in mice

10.1615/ihtc16.nmt.023362 ◽

2018 ◽

Author(s):

Linjing Deng ◽

Jinping Zhao ◽

Yufeng Miao ◽

Xu Hu ◽

Qihong Deng

Keyword(s):

Gold Nanoparticles ◽

Polyethylene Glycol ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically-Based Pharmacokinetic Modeling to Predict Changes in Drug Exposure during Pregnancy Using the Simcyp Simulator

10.26226/morressier.57d6b2b7d462b8028d88e945 ◽

2016 ◽

Author(s):

Suvarchala Kiranmai Avvari

Keyword(s):

Drug Exposure ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Exposure During Pregnancy

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Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12447 ◽

2019 ◽

Vol 8 (9) ◽

pp. 664-675 ◽

Cited By ~ 5

Author(s):

Bridget L. Morse ◽

Jeffrey J. Alberts ◽

Maria M. Posada ◽

Jessica Rehmel ◽

Anil Kolur ◽

...

Keyword(s):

Gastric Emptying ◽

Delayed Gastric Emptying ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Preliminary physiologically based pharmacokinetic modeling of renally cleared drugs in Chinese pregnant women

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2243 ◽

2020 ◽

Vol 41 (6) ◽

pp. 248-267 ◽

Cited By ~ 1

Author(s):

Ling Song ◽

Zhiheng Yu ◽

Yifan Xu ◽

Xiaobei Li ◽

Xuanlin Liu ◽

...

Keyword(s):

Pregnant Women ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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