Combinatorial Use of Sodium Laurate with Taurine or L‐Glutamine Enhances Colonic Absorption of Rebamipide, Poorly Absorbable Antiulcer Drug, without Any Serious Histopathological Mucosal Damages

2003 ◽  
Vol 92 (4) ◽  
pp. 911-921 ◽  
Author(s):  
Masateru Miyake ◽  
Yoshikazu Oka ◽  
Takanori Minami ◽  
Hajime Toguchi ◽  
Masaaki Odomi ◽  
...  
Keyword(s):  
Sodium Laurate ◽  
Antiulcer Drug ◽  
Colonic Absorption

Ecabet sodium, a locally acting antiulcer drug, inhibits urease activity of Helicobacter pylori

1998 ◽  
Vol 345 (2) ◽  
pp. 193-198 ◽  
Author(s):  
Yutaka Ito ◽  
Kazuo Shibata ◽  
Aiko Hongo ◽  
Mine Kinoshita
Keyword(s):  
Helicobacter Pylori ◽  
Urease Activity ◽  
Antiulcer Drug ◽  
Ecabet Sodium

Colonic absorption of acetylsalicylic acid in the rat

1984 ◽  
Vol 15 (1) ◽  
pp. 55-58 ◽  
Author(s):  
Hooshang Meshkinpour ◽  
Daniel Hollander ◽  
David Harmon
Keyword(s):  
Acetylsalicylic Acid ◽  
Colonic Absorption

A fourier transform infrared study of the coagel to micelle transitions of sodium laurate and sodium oleate

1982 ◽  
Vol 4 (2) ◽  
pp. 131-145 ◽  
Author(s):  
David G. Cameron ◽  
Junzo Umemura ◽  
Patrick T.T. Wong ◽  
Henry H. Mantsch
Keyword(s):  
Fourier Transform ◽  
Sodium Oleate ◽  
Fourier Transform Infrared ◽  
Sodium Laurate ◽  
Infrared Study

Differences in the promotion mechanism of the colonic absorption of antipyrine, phenol red and cefmetazole

1987 ◽  
Vol 39 (2) ◽  
pp. 118-123 ◽  
Author(s):  
MASAHARU SHIGA ◽  
MASAHIRO HAYASHI ◽  
TOSHIHARU HORIE ◽  
SHOJI AWAZU
Keyword(s):  
Phenol Red ◽  
Colonic Absorption ◽  
Promotion Mechanism

Integration Traditional Chinese Medicine and Nibble Debridement and Dressing Method Reduce Thrombosis and Inflammatory Response in the Treatment of Thromboangiitis Obliterans

2020 ◽  
Author(s):  
Jianhua Li ◽  
Jingfeng Zhong ◽  
Chunfa Huang ◽  
Jiewen Guo ◽  
Arong Li
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Rat Model ◽  
Inflammatory Cell ◽  
Blood Rheology ◽  
Arterial Disease ◽  
Sodium Laurate ◽  
Thromboangiitis Obliterans ◽  
Dressing Method ◽  
Masson Staining

Abstract Background: Thromboangiitis obliterans (TAO), also known as Buerger's disease, is an occlusive arterial disease. However, the pathogenesis of TAO is still unclear. Research has shown that traditional Chinese medicine (TCM) has significant advantages in the treatment of TAO. Our purpose is to explore the underlying roles of TCM in combination with nibble debridement and dressing method (NDDM) in TAO rat model.Methods: 10 mg/ml sodium laurate was utilized to establish a TAO rat model, and then the TAO mode rats were treated with notoginseng powder (NP), maifusheng (MFS) or the combination of NP or MFS and NDDM. Ganrene’s classification and, blood rheology was evaluated; the pathological characteristics of rat limbs were examined by H&E staining and Masson staining; CD3+ and CD20+ levels were measured by immunohistochemistry and flow cytometry. In addition, inflammation-associated cytokines were analyzed by RT-qPCR, Western blot and ELISA assays. Results: ntegration NP or MFS and NDDM dramatically reduced the ganrene’s classification and affected blood rheology parameter of TAO model rats compared with NP and MFS alone. Meanwhile, NP or MFS in combination with NDDM decreased CD3+CD20+T cells, reduced thrombosis and inflammatory cell infiltration, and dramatically decreased the levels of inflammation-associated cytokines.Conclusion: Our results suggested that integration NP or MFS and NDDM could relieve the symptoms of TAO model rats induced by sodium laurate, which might provide new management strategy for TAO.

scholarly journals Phosphonate reagents and building blocks in the synthesis of bioactive compounds, natural products and medicines

2019 ◽  
Vol 91 (5) ◽  
pp. 811-838 ◽  
Author(s):  
Marian Mikołajczyk
Keyword(s):  
Building Block ◽  
Methyl Esters ◽  
Building Blocks ◽  
Biologically Active ◽  
Type I ◽  
Antiulcer Drug ◽  
Total Syntheses ◽  
Prostaglandin Analogues ◽  
Design And Synthesis ◽  
Neplanocin A

Abstract This account outlines the results obtained in the author’s laboratory on the application of phosphonates in the synthesis of various classes of biologically active cyclopentenones and cyclopentanones. In the first place two general methods for the synthesis of mono-, 1,2- and 1,4-dicarbonyl compounds are presented. The first is based on the use of α-phosphoryl sulfides in conjunction with the Horner reaction while in the second method the oxygenation reaction of α-phosphonate carbanion is a key step. The utility of these two approaches to 1,4-diketones as precursors of cyclopentenones was exemplified by the synthesis of dihydrojasmone and (Z)-jasmone. The use of simple phosphonates, α-phosphoryl sulfides and β- and γ-ketophosphonates as starting reagents in the synthesis of cyclopentanoid antibiotics (methylenomycin B, racemic desepoxy-4,5-didehydromethylenomycin, enantiomeric sarkomycins) is presented. The synthesis and reactivity of achiral 3-(phosphorylmethyl)cyclopent-2-enone and chiral diastereoisomeric camphor protected 3-(phosphorylmethyl)-4,5-dihydroxycyclopent-2-enones as building blocks is discussed as a platform for developing a new access to a variety of bioactive cyclopentenones. The utility and value of achiral phosphonate building block is demonstrated by the synthesis of racemic and enantiopure prostaglandin B1 methyl esters and enantiomeric phytoprostanes B1 type I and II. The range of biologically active compounds prepared from chiral diastereoisomeric cyclopentenone phosphonates is wider. Herein the total syntheses of the following target compounds are presented: enantiomeric isoterreins, natural (−)-neplanocin A and its unnatural (+)-enantiomer, anticancer prostaglandin analogues (enantiomers of TEI-9826, NEPP-11, iso-NEPP-11). The design and synthesis of racemic and four enantiopure stereoisomers of an antiulcer drug rosaprostol is also described.

Therapeutic Effects of Ecabet Sodium, an Antiulcer Drug, on Dextran Sodium Sulfate–Induced Ulcerative Colitis in Rats

2005 ◽  
Vol 50 (5) ◽  
pp. 922-927 ◽  
Author(s):  
Tsunehisa Noto ◽  
Hiroshi Yamada ◽  
Takashi Inui ◽  
Kayoko Okuyama ◽  
Ayako Watanable ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Therapeutic Effects ◽  
Antiulcer Drug ◽  
Ecabet Sodium

Colon-specific delivery and enhanced colonic absorption of [Asu1,7]-eel calcitonin using chitosan capsules containing various additives in rats

2006 ◽  
Vol 14 (3) ◽  
pp. 165-172 ◽  
Author(s):  
Gihan Fetih ◽  
Habib Fausia ◽  
Naoki Okada ◽  
Takuya Fujita ◽  
Mohammed Attia ◽  
...  
Keyword(s):  
Colonic Absorption

Fourier Transform Near-Infrared Examination of the Coagel-to-Micelle Transition for Sodium Laurate

1992 ◽  
Vol 46 (4) ◽  
pp. 701-704 ◽  
Author(s):  
W. M. Cross ◽  
J. J. Kellar ◽  
J. D. Miller
Keyword(s):  
Fourier Transform ◽  
Near Infrared ◽  
Sodium Laurate
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